What Was It Like To Be Part Of Failed Clinical Trial? (r/AskReddit)

people who took part in failed clinical trials what were the worst symptoms you experienced and how bad did they get CLG be ten thousand eight hundred and one did a number on my liver but I don't have leukemia now so I will take it phase I clinical trial for a skin cream designed for emergency burn care half the participants myself not included started sloughing off sheets of skin like lepers for the ones affected their bedsheets or pajamas would pull away the top layer of their arm leg we had only one limb treated per dosage it was pretty gruesome and the trial was canceled after just a week I spent a while worried about it happening then assumed I was in the control group turns out I wasn't but what the cream was doing was making the skin ultra sensitive to sunlight since I worked indoors and had just discovered Team Fortress 2 I didn't get enough sunlight to trigger the side effect Gaming saves lives I took part in a trial of a malaria vaccine the vaccine didn't have any side effects but I did have to sit with a cup of mosquitoes on my arm biting me also I got malaria when I was in grad school I volunteered to be in an experiment at the dental school I needed to get a wisdom tooth out in the deal was that they would test out a new filling material and at the end they get to keep the tooth and I would get $300 and free dental work after the first week it started to hurt after the second week the dentist's were saying to take more than a double dose of ibuprofen and keep taking more unless my ears started ringing but by the time three weeks were up there were moments Wei had to sit down from the pain six months after they removed the tooth I was back for a checkup I asked the dentist if the experiment was a failure and she sort of smiled and said that it was going into wider clinical trials that's when I realized that I had been part of the control group valiantly proving that cavities hurt one of my friends went in for a research study he got paid $4,500 to try out a new met for an issue he was having I think it was an insomnia treatment I'll have to ask anyways now he sweats 100% of the time and has to drink over a gallon of water a day to remain reasonably hydrated not worth mo hyperhidrosis poor guy not quite a clinical trial but in the mid-80s my father was one of the first people to accept a new half of a vaccine he'd suffered badly year-on-year few weeks later he started losing weight feeling fatigued and just generally being ill he was admitted to hospital and after what he describes as hundreds of medical tests failed to find any reason for why he was ill the best they could come up with is that somehow heterosexual man who had never used drugs or had a blood transfusion had somehow developed AIDS remember this is back when it was still being called great it was just assumed he'd get sicker and sicker until he died but one day he started to get better which also stumped the people researching AIDS because that hadn't happened to anyone else the eventual conclusion being they didn't know what it was but it can't have been that doctors basically told him he seemed fine now just get on with his life he went back to get the vaccine again the next year but was told that it had been withdrawn after loads of people died after having it turns out it was just a massive dose of steroids it trashed the immune system and people couldn't fight off common illnesses hard to prove in retrospect but it's assumed he came close to joining them that is freaked I was in a drug trial for our treatment for IBD Crohn's the drug was modulating interleukin 11 basically trying to calm down your immune system so it quits attacking your gut it worked really well I was in remission and felt fantastic then I had my routine blood work done you know that step where the tube is full of blood and the nurse shakes it back and forth a bit when the nurse did that with mine all the color drained from her face she told me to stay where I was and sit very still and she took off turns out that in teluk in 11 is really good at making blood clot when the nurse shook the tube of blood it started clotting that's not supposed to happen turns out my fibrin urchin was so high that if I bumped my arm against the doorframe my way out I would have thrown a clot that would have killed me a few doses of blood thinner later I was good as new the trial was stopped I wasn't the only one who plotted up and the research was shelved I never have found a drug that was as effective for treating my Crohn's though not a failed trial necessarily since all the data was important but my father-in-law was a conscientious objector for religious reasons during Vietnam but the army assigned him to be an insect repellent tester he would spend his days in an enclosed room covered by different compounds to see how his mosquito companions would react some compounds worked better than others that sounds like torture I got a bit of a headache they cancelled to stroke three of the study because some liver values were higher than they should have been still got paid out in full living on the edge I was in a study that was testing how people infected with a certain immune of efficiency disease can't remember what Wilson HIV though real acted to bed bug bites I was a part of the healthy control group I went into a sterile lab got nibbled on safely by bedbugs they put a screen between my arm and the bugs so they wouldn't end up on me and then recorded my skin's reaction for a week did this four times I think I was informed they didn't find out anything significant after the study concluded must have been a tough paper to submit to journals my boobs swelled up until it looked like I'd belted basketballs onto my ribcage then I started lactating like a lot like can't leave my house cause my boobs are geysers constantly shooting out some mystery fluid and occasionally blood then came the vertigo and constant tinnitus after a few days of this I advised the doctor the final side effect was going to be suicide if we didn't start weaning the office crap my parents owned a research center we have had a patient die before the medication was in phase three phase one being the most dangerous and patient stared the research center all the way to phase four which is supposed to be the most safe every time a patient dies while they're in a research study the pharmaceutical company must send out a safety letter which is kept on site with all the names of the patients who died and they're believed cause of death we do not know the exact cause of death since we were not able to obtain any information after but it is safe to assume that it was the medication as it had four patients total died not in our sight but around the world for total I forgot death could be one of the side effects : I was put on a clinical trial for my cancer the sides effects where the normal chemo ones plus risks of blood clots I had one in my brain which resulted in a stroke at age 26 paralyzed for four months worst experience by far in my life daang I tested a bladder control maid that worked pretty well but caused a regular heartbeat it was nice to not have to run to the bathroom 20 times a day but I need my heart to work properly breast cancer treatment I had four hours of the typical hair falls out makes you puke IV chemo then for rounds of Taxotere a somewhat less debilitating chemo plus a clinical trial drug zloda the trial drug was approved for metastatic disease which I didn't have the taxes here makes everything taste like soap I couldn't stand to be in the same room with food thus alota gives you color diarrhea I spent 12 weeks basically eating nothing I called it the Procter & Gamble diet I managed to choke down a chocolate milkshake once a day and had explosive diarrhea for hours after I lost 50 pounds turns out the Z loader had no effect on the cancer but the taxes here worked fine I'm 12 years out from treatment this is my line of work clinical trial data and one thing to keep in mind is that an adverse event is anything that happens during the trial whether it's related or not dude gets headaches sometimes great every headache during his time in the trial is recorded as an A and evaluated and you might think hey I don't usually have heartburn or whatever but I just did now and it's probably the drug but the doctor decides that and if there is any question where are other Doc's and a safety panel who will review it I was on male hormonal birth control for years through clinical trials Gulf it was a huge success with minimal side effects and I wish I could get back on it the drug worked and was safe but ultimately it hasn't been brought to market because most men can't stand to inject themselves with an inch long needle every week side effects were increased energy fat loss and increased libido not a failed trial but I signed up for a medical study where they had to remove the lymph node from my body they were paying $300 so I figured what's the worst that could happen right well they didn't tell me that a lymph node was going to be taken from my bikini line by a 50 year old surgeon who had to rub it in all over my hoo-ha he sewed it up a little funny so I still have a huge scar and the wound was right where my leg bent so I walked funny for like three weeks if anybody asked why I was limping I had to tell them about my poor disfigured rag and it was terrible and three stroke ten still got $300 I took part in a clinical trial for NASA where they paid me to essentially sleep for a month in one room I couldn't go outside couldn't leave the room could play on my phone and go on the computer but that was about it I ended up sleeping probably 16 18 hours a day out of boredom the trial wasn't technically a failure but afterwards I had trouble sleeping usual amounts of time as well as doing day-to-day tasks my mother-in-law participated in a large-scale trial of aspirin being tested as a cure-all for the elderly the pharmaceutical company was trying to prove that everyone should take aspirin daily beyond a certain age to reduce blood clotting coincidentally it's also a great way to sell a lot of aspirin my in-laws were both part of the trial and my mother-in-law had some medical issues that ended up involving internal bleeding if she hadn't been on aspirin she would have been okay but due to the blood thinning aspect off the aspirin the problem escalated badly and she ended up vomiting blood all over her hospital room and nearly died it's hard to describe the feelings of horror and helplessness watching her vomiting blood on the floor while nurses rush into the room from there we're telling you to stand back and take emergency action to try to stop her dying one of the nurses later told us that we were extremely lucky that she lived a few weeks after her near-death experience a group of people from the pharmaceutical company showed up unannounced at their house and ever so gently pressured them into signing a waiver withdrawing from the trial and saying they wouldn't you being nice trusting elderly people they signed it we later found out that the whole large-scale trial had been can that same day since they got her agreement to withdraw won't be recorded in any official record that a trial nearly killed her just that she withdrew from it the whole thing really stank in my opinion I imagine that they want to keep their options open to run more trials in future so they didn't want her negative result hanging over them yep anytime anyone tries to get you to sign something saying he wants you don't sign it talk to a lawyer instead I was in a clinical trial for an allergy medication my allergies were terrible throughout the trial so either I was in the control group or the medication was a failure the worst part was that my allergies were awful I couldn't take other allergy medication and it was just not fun I don't think I would do it for a condition that I need to be treated for because being in the control group means you suffer had blood drawn repeatedly with shirts also mediocre cafeteria food on the plus side one of the other testes was a Vietnam vet who had crazy stories and brought in Pauly Shore movies for us to watch Mystery Science 3000 style I know that this isn't what you meant but for just a brief moment I thought one of your testicles was replaced by a Vietnam vets testicle that had also been in a Pauly Shore movie I'm sad that wasn't the case I got pregnant trial for a non hormonal birth control gel first month used it probably three or four times long-distance bf we only see each other on weekends if that BAM I'm 11 weeks in it's okay ittsan planned I thought about terminating could we both wanted kids and we want to be together so we decided to figure it out we are both in graduate school both graduating before due date so hopefully we'll be more financially secure when it gets here in the worst part is probably having to explain I usually just say it wasn't planned and people don't ask but with my parents and close friends I had to explain I ended up just saying we were switching methods and things got messed up which is the truth not as a subject but a research coordinator the worst I've seen is that it didn't work I know it's research and that if we knew it works it wouldn't be research but it's still disappointing a couple notable ones being on a conference call with people from other study sites and hearing the sponsor representatives sadly announced that the data analysis showed no benefit and about how you be receiving closeout instructions meanwhile you know there aren't real good alternative treatments for this disease nothing that worked forever at least and they were more painful than this and you're just sad and disappointed and thinking about what to say to your study patients another was a study of a small device to cure something untreatable and debilitating but not fatal early tests showed some promise so they got funding to expand testing at one point a TV show painted the results a super promising and a pure and we got swamped with calls and spent weeks explaining to desperate people from literally all over the world about how we couldn't enroll anyone else FDA restrictions super illegal to try to get around and we were sorry it didn't work anyway the inventors couldn't raise more money to try to adjust it they went bankrupt the assets got bought out by some company and I think it got shelved we were still getting phone calls a few years after it all closed out a decade later a better variation on the idea with surely better tech is finally showing some real results from what I can tell I did a clinical trial attempting to treat Crohn's with an antibiotic it turned my book pee and even my jizz bright yellow come to find out it was a dye they used in the placebo to make it match the real deal final year of university I had to complete three in paid practicum placements two over one term I had to quit my job to do so obviously I knew this was coming so I'd saved a bit of money in the lead up it not enough and once all of my prax were done I was in a very bad place financially and took a couple of weeks to get a new job I ended up doing a phase 3 trial for a new malaria drug and got paid about 2500 Australian dollars for my participation it was basically a bomb assay to monitor uptake and liver markers across all participants no control as such everyone received the drug and metabolism monitored throughout what the frick thought i i've eaten fast stranger stuff in my life with no idea where it came from about time I got paid to eat a questionable pill rather than paying to eat questionable pills well this little sucker was quite questionable indeed single dis malaria preventatives treatments are no joke for starters even though it was an overnight trial there was no sleep to be hired least of all because they took our blood hourly the medicine invoked some sort of bizarre half waking fever dream state I'm not sure how valuable the data they got back from this trial was and somehow I'm betting the drug went to market in the end all of their questions were about pain and they were checking liver markers monitoring vital ztc and little attention was given when I said that I think I might be hallucinating a little bit or that I felt very strange indeed I mean while I'm laying in a hospital bed watching some sort of demented version of the Dark Ages bloodletting ceremony take place around me the faces of the nurses stealing my blood took on sinister expressions and their hospital gowns shifted into some sort of nun like religious attire I thought one of them winked at me and was deliberately making sexual gestures towards me I was thirsty like I had never been in my entire life but the water they brought me tasted like heavy metals and my paranoia told me that they were trying to poison me if it went from my past experiences with psychedelics and the fact that I could clearly remember I had been administered a drug I probably would have freaked out this thing felt like an extremely strong deliriant when I looked into a mirror the skin on my face was all patchy too and I'm pretty sure that was not a hallucination most others in the trial seemed to be sleeping okay all had the foresight to bring a laptop and some movies I was pretty much fine after a good night's sleep the next night and the money really helped me out but I never participated in any more medical trials I once attended at trial for some kind of antidepressant anxiolytic first they injected me cholecystokinin to cause an anxiety attack and i had to evaluate the severity it was supposed to be the maximum 10 stroke 10 but it wasn't for me 6 stroke 10 I realized that I have had anxiety attacks before I was evaluated as a healthy person but it turned out I was not and in denial about my mental health I didn't follow - the next step was given rotation back in the 90s when it was still being tried now they know the 2 out of every 100 teenagers successfully commit suicide and I have been living with a voice inside my head telling me to kill myself ever since my ex was on it before we met it had probably been close to 10 years and he still lives with suicidal thoughts and cystic acne and he's going to be 29 it's freaked you have been visited by the ingenious Joe comment brain so you always see the glass half-full if you are new to the channel you can subscribe I publish new videos every day until then check another video or don't either way have a great day you magnificent people [Music]

Channel: Updoot Studios

Views: 100,950

Rating: 4.8861871 out of 5

Keywords: #updootst, updoot, updoot reddit, updoot everything, reddit on tap, toadfilms, pewdiepie, reddit, askreddit, funny reddit, reddit stories, top posts, reddit top posts, reddit cringe, comedy, reddit compilation, /r, r/, r/askreddit, top posts of r/, askreddit reading, best reddit posts, top posts of all time, people of reddit, askreddit question, ask reddit, subreddit, sub, reddit clinical trial, reddit trial, reddit experiment, reddit science experiments

Id: ibjZ_DDZvUs

Length: 19min 4sec (1144 seconds)

Published: Fri Dec 13 2019