Dr. Rhonda Patrick Goes In Depth on the Benefits of Vitamin D

the Joe Rogan experience this seems like in the beginning at least they're trying to figure out what the correct treatment was for these people as they were just showing up in mass in the emergency rooms and they didn't really know and doctors they varied in how they approached it my friend Michael his doctor didn't put him on a ventilator and he said if I put him on a ventilator he's probably going to die right because he said his body's gonna stop working because it's it's gonna let the ventilator do the breathing for him and it's gonna give up and when he was talking about after the fact what Michael was talking about was how that is proven to be correct in New York and that some monstrous number like eighty percent of the VA put up ventilators wind up done not just New York I like I've had friends that are physicians that of like you know in New Orleans I mean the same thing or it's like a you know I there was someone on my team we were looking we were doing some research on this and I and I didn't sort of dive into the whole thing but he was he was telling me that ventilators do actually like cause more damage to the lungs and like like he'd been reading some studies to like confirm that and he was pretty certain that that ventilators actually cause damage and actually could like induce damage where it's like making it worse so that's so bad I don't know I don't know all the specifics oh that all I know is that looking at the statistics like if you go on a ventilator I mean surely it seems like the outcomes not very it doesn't seem like it's gonna be very good right now it's hard to say is that the cause of it or is it right you know just that they're so [ __ ] up by the time they get on a ventilator they just wind up dying right well here at like the the there's been some really interesting data looking at like in there so in the Philippines and Indonesia where else nor think New Orleans as well they've looked at patients that have died and their vitamin D levels and been bitten basically like in the Philippines you know people that for like every standard deviation increase in vitamin D levels serum vitamin D levels you know the people had like an 8% or were eight fold eight times less likely to have a severe form of Koba 19 and if they had and they were 20 times less likely to have critical like critic critical form of COBIT 19 whoa in the so that was the Philippines in the Indonesia was a really interesting study where like they measured vitamin D and this was measured in the patients there's been some vitamin D studies also where they're like looking at you know countries that have been affected the worst and they all like have low vitamin D and it's like okay well anyways that's correlation but well so is this but a little it's a little stronger data the in the in Indonesia patients that died ninety abut almost 100% it was like ninety eight point something percent of patients that died with cope in nineteen were vitamin D deficient four percent of patients that died from Koba 19 were vitamin D selfish are sick four percent only four percent were five item indeed sufficient so basically they were all vitamin D deficient all the ones that are dying whoa crazy right and New Orleans had some crazy crazy would be the mechanism that would cause so I think there's all right can we cut can we get into vitamin C please do it's a big I really because of you I take 5,000 IU's a day awesome right now I'm taking 5,000 IU's a day hmm you know 70% of the US population has insufficient vitamin D levels which is considered less than blood levels less than 30 milligrams nanograms per milliliter this is something your body can generate naturally if you're exposed to so on a daily basis yes that's the best way to get it it is but the problem is is that we don't go outside anymore and you never know yeah exactly yeah now more than ever but even terrible recipe right vitamin D deficiency is what makes it worse and then you're staying inside so you're not getting any vitamin D yeah you're becoming even more deficient you know like like someone like 28 percent of the US population is actually diffic 20 nanograms per mil you know like that's defined deficiency so there's a lot of people in the United States as you mentioned you make it from the Sun so particularly UVB radiation there's a reason why I want to talk about this you make it from UVB radiation exposure you know basically you're it's made in skin and but you know there's certain times of the year depending on where you live in a more northern latitude where that UVB isn't even hitting the atmosphere so you're not making vitamin D also if you have darker skin melanin protects you like the whole you know people with darker skin people from maybe Africa or India or South Asia they're more equatorial regions they're closer you know closer to the equator and there's more UVB radiation throughout the year and so as a protective mechanism to not get burned you have melanin which protects you right the problem is is that melanin also blocks your your ability to produce vitamin D but if you're out in the Sun all the time you know in a place where you're getting UVB radiation it's not a problem well this is the very reason why people in places like Scotland and England have such pale skin exactly cloudy all the time so your body sort of develops its own ability to absorb more vitamin exactly so what happens when you take some wood what happens when you take a person from from South Asia from India from Africa and you put them in Sweden or in Minnesota or in the UK a place where UVB radiation doesn't hit most of the year and you don't give them a supplement what happens is they become severely vitamin D deficient severely and what happens when you take I mean I mean you can throw this on the you can flip flip this over and say okay what happens when you take the guy from the UK the Brit and put them in Australia like without any sunscreen or without a hat or they're gonna yeah so I mean do you think that this could be a factor in why so many African Americans are getting hit so hard so here's the thing so African Americans are there's lots of all right African Americans are in the United States there's been studies African Americans are severely deficient they're 28 times more deficient in vitamin D than than Caucasians Wow yeah and it's it's it's because it's because they have darker skin and you know if they're not getting enough Sun they're not getting enough Sun because people stay inside more people stay inside you know it's not it's not like the old days when we were out hunter-gatherer and out in the Sun all the time where you know we're inside all the time we're in school work in her office in her cubicle so the CDC you know obviously there's been studies showing that african-americans are more hit but they didn't really correct for tons of like other factors because socioeconomic status is important how other health factors you know and but there was a big study just released not long ago from from like the National Office of Statistics in Britain or something like that I don't know what their official name was but they released some statistics from England and Wales and the I don't know what the correct name to say I mean that the blacks they're basically living in England and in Wales are four times more likely to die of covin 19 than than whites when they when they adjusted all that data for socioeconomic status and for other health factors there were two times more likely to die so clearly socioeconomic status and other health factors are playing a role but there's something else unidentified and I think it's vitamin D I think that you know so you know the vitamin D like it hasn't look vitamin I'm not saying that vitamin D is going to prevent you from getting copa90 nor it's a treatment although I am involved in a clinical study where we're gonna be testing a very small open arm study we can talk about but you know I'm not a physician or medical doctor I've never intubated anyone so don't think I'm saying that I don't want people to think I'm saying it's a treatment I just want to it's a hypothesis that needs to be tested and thankfully there are clinical trials randomized control trials that are now ongoing and there's some that are recruiting but just a statistics that you've already listed about vitamin D and the people that have had kovat 19 those are insane it's insane and also in Sweden there's a huge population of Somalis that have migrated to Sweden and they have been identified as being severely vitamin D deficient because a lot of the Somalis have off they're also on like autism rates are really high there and there's this link between I published a link also between vitamin D and autism but so there's been studies looking at vitamin D levels in the Somali population I mean they are so deficient because you're taking again you're taking someone who's supposed to be who's you know evolved to be getting a lot of Sun but not burn from it and then and then putting them in a place where they can't get any vitamin D from the Sun and if they don't get a supplement like they're gonna be deficient you know and they're so much more likely they're like it's it's wreaking havoc in Sweden on the Somali population that is so logical yeah it's it's it and then okay so elderly elderly are like insanely more deficient I forgot the exact number obese also the obese people are like three times more likely to be vitamin D deficient in the United States why is that because vitamin D is a fat-soluble vitamin and it's less it's been shown to be 50% less bioavailable so you have to you make it in your skin it's stored in fat and you know it's released and when you know basically into the bloodstream and then it can gets converted into a hormone this hormone regulates five percent more than five percent of the human protein encoded human genome it's a lot of genes that's a height to hormone like can you imagine just walking around without testosterone you're a man that's a hormone I mean like because there's a lot of people that are deficient in vitamin D and this it's a steroid hormone it gets converted into a hormone like this isn't just a vitamin you know it's important it's really important so I went off on a tangent but anyways what can I ask you this boy we're off in this tangent what is when you what is happening to people when they are vitamin D like what's happening in the vitamin D deficient what is happening in the body that's causing their immune system this this hormone deficiency not having this vitamin D whether it's through some exposure so there's lots of things I mean it plays a vital into your scepter Zahn like your immune cells and and the reason for that is because one of the hormone vitamin D hormone binds to the receptor it activates all these genes and that the genes do stuff that are you know regulate immune function you know there's there studies that have shown people and I love these studies because because they basically take away the people's complaints about you know there's lots of epidemiological studies showing that low vitamin D is associated with disease XY or Z and everyone's like well you know they're out in this they're not in the Sun as much so they're not as healthy they're not as physically active or not whatever even though those pounding factors are usually corrected for its old at the end of day it's an association right and everyone's like correlations on causation which is true but sometimes you got to like a look at the full body of data you know there are genetic polymorphisms so so there are people that have variations in genes that cause them to genetically have lower vitamin D and so this this is called Mendelian randomization when you can take a person that's that has a genetically like it's they're genetically low vitamin D so you're not categorizing them based on their vitamin D levels you're categorizing them based on their gene and those people are more likely to die from respiratory infections just based on that gene alone so yeah at that gene that it's known to lower it lowers vitamin it leads to lower vitamin D levels and so like those people are more likely to die from respiratory infections than people that don't have that which it's a great way of kind of randomizing people by their genes as opposed to doing a randomized control trial those have been done as well there was a study that was over 25 randomized control trials people that were given a vitamin D supplement varying doses either weekly or daily monthly didn't work they're the people with low baseline vitamin D levels so people that were like deficient they were 50% less likely to have a respiratory tract infection if they were taking the vitamin D supplement over 50% actually and people that had already normal levels still had a protective effect there was a little 10% less likely so even people that were already considered normal taking about vitamin D supplement helped prevent the respiratory tract can you take too much vitamin D yes you can you can too much so right so the the upper the tolerable upper intake has been set by the nutrition board the Institute of Medicine to be 4,000 IU's a day but there's been studies that have shown that you can I mean people that have taken you know 10,000 IU's a day for for multiple years haven't had any hypercalcemia or had you know problems but too much vitamin D can be toxic it's not good to take that it's best to like get a vitamin D blood test and I think that personally there has been a trend for people that have blood levels higher than 60 II may have just a little bit higher calcium level but not much not like it's not like anything to be hugely concerned about but there are studies also showing that either vitamin k1 so there's been a meta-analysis looking at of 12 different studies I think where vitamin k1 or vitamin k2 were given and both of those improved bone mineral density and prevented any hypercalcemia because when you take vitamin D you absorb calcium better like something crazy like 40% more dietary calcium being absorbed Wow so so the problem is is that calcium can easily form a precipitate in in in general and particularly when phosphorus is around and phosphorus is another thing vitamin D does increase the absorption of but again like I said you know it's really like it's really hard to find any studies where vitamin D is causing you know hypercalcemia unless it's like really really high dose for for a while I personally think taking the the vitamin K and what's interesting about the vitamin k1 versus vitamin k2 with without going into too much of a tangent is basically the the vitamin k1 normally it goes to your liver and it's involved in blood coagulation but when there's enough vitamin k1 around it stays in the periphery and it moves calcium periphery being blood stream it moves calcium out of the bloodstream and takes it to places where it's supposed to go like the bones and the muscle vitamin k2 usually stays around the periphery and that doesn't really go to the liver so it usually that's usually what it's just doing is you know moving calcium out and bringing it to the bones and so I take a I actually have k1 in my multi that I take but I also take a k2 supplement mk4 I take it like a couple times a week well the K ones in my multi so I don't fight omim k1 is really it's found in dark leafy greens so I get a lot of those as well a lot so I'm getting a lot of k1 vitamin k2 is not as it's not as readily found in like the Western I mean it's like the food that's highest in it is that fermented sweeping natto mm-hmm but it's like small quantities and like do you ever get concerned from the high volume of leafy greens do you ever get conservative oxalates or getting kidney stones or anything lines no I like the few studies that I've seen it's and people that are like doing insane juicing and they're already like messed up you know so I'm not concerned at all like even like the oxalate so oxalates actually I don't want to go into this but so ya know I don't consider I want the vitamin D thing is so important I mean like the the the reason there's a big reason I think that vitamin D is so important it's for the lung function and the respiratory of lung function but what's really interesting is that you know the the very receptor that this Tsarskoe scope virus binds to to gain entry into the cell it's called a stew that very receptor plays a really important role in preventing lung damage and and basically and preventing acute lung injury preventing acute respiratory distress syndrome ARDS and what's been shown with SARS Kove one is that kasarkode one also binds to that receptor ace 2 it's called and that's how it gets into the cell just like the Sarge Cove 2 when when it binds to the receptor it like it attaches in like through this like weird endocytosis mechanism it takes the receptor in and decreases the receptor what's called down regulates down regulates the receptor so you end up having less ace 2 which causes like can cause severe lung injury not having the ACE 2 it plays a big role in protecting that's been shown in multiple studies like so the SARS Cove one virus does that it's thought the Sarge coped who also does it because it goes through the same entrance through the same receptor and it's been shown that like if you for example if you give mice lipopolysaccharide or something that's going to cause lung injury and then you give them vitamin D so the lung injury itself also causes the h2 receptor to decrease and it's so it's like this vicious cycle of like making the damage worse but if you give my vitamin D before that happens the h2 receptor increases and it protects them from the lung injury but you give the vitamin D to control mice that don't have the lung injury it doesn't do anything to the ACE to receptor levels so it's not like full stop it's not like you know drugs the way drugs are designed is they like they target a certain molecule and they bum they do their thing they either increase it or decrease it a lot of times with like hormones you know vitamins things like that they're they maintain homeostasis you know what I mean does like so when when [ __ ] goes wrong they fix it they're not just like boom full-stop gonna like increase something when everything's normal so and that's important because there have been some concern about taking vitamin D increasing the ACE 2 receptor and there's another study that was with hypertensive rats where the hypertension caused a stew to go down and that like makes lung it makes all sorts of problems it also causes like kidney problems and all sorts of things right but but the vitamin D increased the ACE 2 but only in the hypertensive rats not in the normal control rats again so you know and then there was another study that was like some other messed up diabetic animal model where the vitamin D actually didn't increase the ACE 2 receptor but it increased what's called soluble ace 2 which is in like it's in the periphery and that actually potentially could bind Tsarskoe of two virus and prevent it from it's like sequestering it preventing it from entering the cell that's actually being explored as a potential therapeutic so but the bottom line here is that sometimes you'll hear this ace 2 receptor and that's how the virus gets in it's like I don't want that I don't want I want less of that because that's how the virus gets in but like like biology is always way more complicated than just a simple taking it out of a big picture right you know so like the ACE 2 receptor the ACE two is part of the Rena and angiotensin system it plays a huge role in inflammation it's also like when you when you decrease ace 2 all these signal signaling cascades happen and it's like a stew is important for producing pro-inflammatory cytokines at the end of the day without getting into all the stuff you know specifics so it causes massive inflammation to have a decrease it it basically causes acute lung injury it exacerbates it I mean it's crazy so I really I just I really can you imagine if vitamin D really did help like if there was something that could be given along with the other stuff from desi beer or whatever whatever it's going to be the stuff that we identify but like vitamin D so is so cheap it's so easy and so many people are deficient and insufficient you know like so yes as you mentioned there is you know you don't want to take too much vitamin D you don't want to like you know overdose on it but I think in the short term you know particularly like in the short term and particularly impatient people that have already been infected you know it may be why is to try giving your patient like if you're a physician you know dealing with this may be may be wise to try and didn't see their vitamin D levels and perhaps give them some you know is this being explored pop I mean is this something that people are talking about publicly because I all I'm hearing is drugs and possible drug remedies potential vaccine that they're working on the future I'm not hearing anything about methods nutrition that boosts your immune system this is one of the reasons why I really wanted to talk to you right now yeah let's definitely talk more there are yes it is so there are clinical studies unfortunately not a ton of them in the United States that are looking randomized control trials looking at vitamin D the effects of vitamin D on already you know patients with Co but 19 which what would be great is like giving him to like first responders or health care workers and seeing like how does it how does it what it what role does it play in prevention cuz that's really the easiest thing right I'm involved a friend of mine dr. Eric Gordon he he's put together so I kind of with his help I've helped him design a open-armed trial very small forty patients where were where he is going to be giving them 50,000 I use every five days of vitamin D so it's like a weekly dose because a lot of times these people are severely deficient so you want to give them a higher dose you know and and for you know doing doing 50,000 I use weekly isn't you know something that's necessarily going to be toxic or anything like that and then we're going to you know we're doing some other things vitamin C 3 grams the three times a day and then vitamin b1 we can talk about that Simon as well but so yeah there are I think there's like open-label triable open-label trials are just kind of a start it's like if you if you see something plus we're doing like kitchen sink right we got this this and this and this so I think vitamin D really is is the star you know I think that potentially you know I think it really should be explored I think it has huge potential it has to be shown like this isn't something that people can just you know take it home and think I'm protected like that is not the case we don't know that you know there's no data showing that but I think it has huge potential you know so how would one do a randomized control study on vitamin D and people that have kovat 19 it seems like well they're gonna do a magician - they're gonna in addition to standard of care so it's basically whatever the standard of care is and that's that's what we know is happening at the hundred in hospital in New Jersey but as you said it seems like what's really critical is getting into people before they get it yeah I would love to see that study done yeah if anyone can do that study amazing that would be because that would be like to me get it to nurses get it first responders yeah I just just get the information out there and and have nurse or nurses and first responders take it I mean you know vitamin D is something again like 70 percent of the u.s. population has insufficient levels you know that is such a crazy number it is it's generally safe to take like like 4,000 IU's a day it is taking five I am but for thousands the top the what they they indicated as the tolerable upper intake so why do you take five I'm just taking five thousand right now because that's like I could buy the five it was like I didn't want to take two pills of the two thousand well that's me - I got one pill it's five right and so I had my my levels measured literally like I did went to lot two quest quest labs like a month before all this lockdown happened so I got my data back pretty pretty recent and I still hover around 50 nanograms per mil even though before I was taking 4000 it's in generally speaking 1,000 IU's will raise your blood levels by about five nanograms per mil and there are people with different variations and genes that are related to vitamin D metabolism where they have lower levels and they need a higher dose the only way you're going to know that is by of course measuring your vitamin D levels multiple times and then potentially been doing like a genetic analysis you know as well but you have to measure your levels like that's the only way no of course right now it's like you can't go to a laugh it's like hard to do any of that I mean the things that are like moronic yeah yeah but right now when you need it but the vitamin D I mean I'm just so like I just I have so much I have high hopes for it you know and maybe maybe I'm a bit of a enthusiast with it you know I do like I've studied vitamin D so much I've got two publications on it I certainly like you know you said so you know there take that with a grain of salt as well but I just think the data is strong I really think the data I think it's mounting data and I think that eventually something will come out and it's going to just like the randomized controlled trials showing that it protects against respiratory tract infections of course everyone wants randomized controlled trials like no one wants to believe anything until it's a randomized trial I'm just I'm amazed that the numbers of people that are deficient it's so stunning and when you point out the number of people that are deficient that actually wind up having severe kovat 19 problems right yeah I know it's stunning like some some of those numbers like the missing link it's like it's right there I think that's a really good hypothesis I do I think it's a really good hypothesis I want to believe it because it's easy it's safe and I think people need vitamin D anyways I mean yeah you know so so of course I want to believe it you know but like there was this interesting study where African Americans who are very deficient in vitamin D they were given a vitamin D supplement for like a month and it decreased their epigenetic age by like two years I mean yeah so that's a four month something like a month I think yeah in a month they decrease their epigenetic age by two you okay don't hold me to the month may give me some month or two months but I think it was a month most most people said three months that's crazy most of these studies are about a month yeah so yeah by one point eight years so what it's indicative of they're suffering from this vitamin D deficiency this alleviates that suffering and then it puts the body in homeostasis yeah it's changing 5 percent of the human genome that's a lot it's a lot yeah that's crazy number when you think about it it is not it's not just a vitamin right yeah hormones supervisor can you imagine it's like what happens when you go into menopause well you're not making your estrogen I mean stuff goes wrong I mean it's a hormone like Esterbrook estrogens a hormone you know testosterone is a hormone it's a hormone you know it's low it's it's important so you know so that's the if you have the dr. Rhonda Patrick pyramid of supplementation for preventive symptoms of coma at nineteen or preventive measures dealing with kovat 19 that's your base that's number one I take vitamin D I certainly don't know if it's going to prevent over nineteen but nothing hoping it does take it hoping it works but I'm saying preventive I mean like getting your body healthy I mean my mom got my mom my dad I got my whole family everyone's on the the routine you know that vitamin D is like the most important so that's the foundation is vitamin D right now yeah I mean it's it I'm always trying to get them to have that but like it's easier to convince when people are scared people are more likely to make change when like you can't like if something they have to be motivated to make the change themselves they're just otherwise it doesn't work you know so I think that in this case people are motivated especially people in my parents generation that are older because they're they're more scared they're more scared that they could be affected by a severe you know case of this right so so I think that's the certainly you know the issue [Applause]

Channel: JRE Clips

Views: 2,269,159

Rating: 4.8972239 out of 5

Keywords: Joe Rogan, JRE, Joe Rogan Experience, JRE Clips, PowerfulJRE, Joe Rogan Fan Page, Joe Rogan Podcast, podcast, MMA, Joe Rogan MMA Show, UFC, comedy, comedian, stand up, funny, clip, favorite, best of

Id: tBSfIckPV44

Length: 28min 8sec (1688 seconds)

Published: Thu May 14 2020

Reddit Comments

[u/moneyocean]

Can someone explain to me why people keep reposting info on vitamin D on a nootropics sub? I understand the other health benefits of vitamin d is great but this has nothing to do with the brain benefits? Wouldn't another sub be more suited for this?

[u/[deleted]]

I'm in an essential job that puts me into contact with a lot of people. I've been in close proximity in an enclosed space to people coughing and not wearing masks every day at work since this started. I take a multi-vitamin, 1000mg vitamins c every day with a few others, and 5000 iu vitamin d every other day. I haven't gotten sick.

I've been convinced that my vitamin regimen has helped prevent me from getting sick. My girlfriend is also in a job that puts her into contact with a lot of people. She hasn't gotten sick and has a similar vitamin regimen. I'm even more convinced that our vitamin regimen has helped prevent us from getting sick after watching this.

[u/td42]

Where is the actual evidence that it benefits covid?

Remember when people claimed Vitamin C prevented/cured HIV because we observed low abscorbic acid in HIV patients?

There are many factors which people are perhaps overlooking. For example one of many is the fact vitamin D levels would be skewed to be lower in observed patients because of the very fact only the sickest that already had lower levels from staying in the past few weeks and barely eating (correlation, not causation) are going to hospital in the first place.

For the overwhelming majority we're not even checking if they even have it (covid). Let alone their vitamin D levels!

That's when you realize claims like "Vitamin D offers covid benefits" is ridiculous. To outright suggest Vitamin D can prevent/benefit something when you literally aren't checking if people even have the illness (let alone their Vit D!) in the first place for 99.9% of cases should show you how biased and flawed such a claim is.

As they say... Correlation is not causation.

[u/h1ddenagender]

Can someone explain what we’re referring to when you say vitamin D? I thought we got our requirements from the sun....

[u/Womcataclysm]

Joe Rogan?...