New syndrome

well War welcome to today's talk Sunday the 19th of November now researchers from Yale in the United States have identified a post vaccine syndrome occurring after the covid vaccinations post after syndrome describes a group of clinical features so like AIDS for example is acquired immune deficiency syndrome it's not just one symptom it can affect the brain it can affect the the lungs it can affect various parts of the body because it's a syndrome and it's the same with this postvaccine syndrome a range of possible presentations now the most common ones are uh postvaccine syndrome most common symptom described by the participants exercise intolerance 71% had exercise intolerance now of course the heart is essential to maintain cardiac output to circulate the blood around the body if the heart is not working properly people will feel tired and be unable to exercise we don't know if that's the case here we just know that exercise intolerance was complained of by 71% of participants excessive fatigue 69% now excessive fatigue could be the cardiovascular system could be the respiratory system could be the central nervous system we don't really know that we just know that 69% complained of excessive fatigue 63% complained of numbness that's very likely to be a peripheral nervous system disorder different parts of the body being numb brain fog was 63% so cloudy head not being able to think clearly could be neurological could be due to the blood supply to the brain could be due to the way the brain uses nutrients and oxygen wide variety of causes but 63% reported brain fog and 63% also reported neuropathy neuropathy just means disease of the nerves it doesn't tell us much detail but it tells us disease of the nerves 63% reported that and also in the week before this is a couple of year this is this is quite a long time after vaccine a year or more um a lot of people in the week before were still complaining of anxiety and depression related symptoms and I don't know about your experience but um a lot of people have been reporting anxiety and depression to me um let me know if that's the case for you is there more anxiety and depression in the world now than there was say in in 2019 interesting question anyway let's go straight on and look at the detail of this paper now that's what this is about do stick around it is really quite remarkably interesting this is the paper here now um we'll look at the uh a little bit about the people that that wrote the paper and uh the likely validity of this paper but it's all there um and it's it's remarkably um easy to read for a medical paper I must say very very straightforward to read you could read this in half an hour 40 40 minutes easily you could read it quite quite uh quite comprehensively so descriptive analysis uh of reported symptoms of patients experience experiences after covid-19 immunization now this is the Yale listen to immune symptom and treatment experiences now study and uh let's let's just take a moment to agree with this wholeheartedly it's about time we listened to what people are saying if a patient is describing their symptoms to me and I don't listen then that's a fundamental failure of my duty as a healthcare professional as far as I'm concerned for example we talk I taught student nurses about pay P for for getting on for 30 years well it would be 30 years really anyway we always said that pain is what the patient says it is existing when they say it does we have to listen to our patients most of the information we get about our medical examination is from the history is what the patient tells us we get a little bit from blood tests and other things like that but most of it is from what the patient tells us we have to listen we haven't been good at listening that has to change if people are complaining of symptoms we have have to listen to them and take it seriously not poo poo it as some psychiatric disorder which all of a sudden seems to become common around the world I don't think so anyway um that's the study um now this is a pre-print paper so it's not peer-reviewed but um it's quite reputable area so we've got Center for uh outcomes research and evaluation Yale uh Center for IMU infection and Immunity Yale School of um medicine a section of cardiovascular medicine Applied Mathematics uh medson University of Toronto it's all pretty mainstream academics uh Chicago um so although this isn't peer- reviewed yet I've read it and and really it would be pretty hard to get the maths wrong on this so I strongly suspect that this data is accurately representing what these people reported and would expect to see this in peer-review Publications pretty soon would imagine it' be fairly straightforward to get that published and it will happen but we want to report it as soon as we can right introduction a chronic postvaccine syndrome PVS after covid vaccine has been reported but has yet to be well characterized but we're characterizing it now postvaccine syndrome so chronic syndrome with symptoms that began soon after vaccination is how they are defining this which makes perfect sense that's a very logical way to describe this now the method they used this is people who joined the study May 2022 to July 2023 241 individuals reported which is quite a good number for this sort of semi qualitative study describing the number of um uh the the type of symptoms that people are suffering from Mostly from the United States now I will be putting a link at the end of this it looks like you can join this from anywhere in the world so so that that's in the description uh underneath but we'll mention that in a minute patients 18 years and older um who self-reported postvaccine syndrome after postac after covid vaccination and they also did deep immune profiling is used for some individuals so some people they just listen to their symptoms and others they did deep immune profiling so looking at the white blood cells the different types of white blood cells the chemicals given off by these white blood cells thorough analysis of the uh the uh the blood cells responsible for immunity so there was this biological aspect as well now the results uh median age was 46 among participants with postvaccine syndrome uh 55% had received the fisa 86% had received the madna they're the only ones that are mentioned Johnson and Johnson was given for a time in the states of course as well um so um fisa mostly but maderna also um now time from index vaccination first vaccine to uh uh symptom onset median time was 3 days but it varied but well into quart hour range that's 50% of the participants who responded was between 1 and 8 days but the thing is some of these features seem to go on for an awful long time now when these um this line of um treatment first came out it was very hard to conceptualize that there would be such potential long-term issues that's really been quite a surprise and a major uh disappointment in fact it's quite concerning really um as as many of you uh sadly uh know from personal experience um time uh time from vaccination to symptom survey completion so that was when the symptoms often typically began just short after the vaccine but we going on for a long long time here so the time from vaccination to symptom survey completion uh the average time here was 595 days into quartour range 50% lying between 417 and 661 days this is a long time postvaccine and this is a quality of life uh survey here this quality of life analog scale looking at various parameters and they found it was 50 so what what this scale does um you you would say um zero is terrible 100 is good so you can see a lot of these people aren't doing very well on quite a few quality of life parameters which is pretty uh well very is very sad and terrible for the individuals five most common symptoms as we've said exercise intolerance 71% exercise fatigue 69% numbness 63% brain fog neuropathy 63% now this is perhaps I think you could almost say equally concerning really in the week uh before the survey was completed people were asked to give their experiences and um the people in who reported had experienced these at least once in the week before they um filled out the uh the questionnaire feeling uneasy 93% at least once in the week fearfulness the anxiety that we're talking about 82% overwhelmed by worries 81% feeling of helplessness 80% anxiety 76% depression 76% hopelessness 72% of course you can see that these percentages are so high that many people are suffering from more than one and um feelings of worthlessness 49% experience those and there are also concerns related to living situations food security and uh accommodation so we see that this postvaccine syndrome is being reported by these participants to affect many aspects of life these medical aspects these uh psychological stroke psychiatric aspects and their ability to just provide for themselves normally in the world um so I'll put those uh in the description they're all listed there um all totally horrible uh horrible features uh so the people filling out these experience those at least once in the week now symptom severity when asked to uh quantify their symptoms um not from trivial to 100 on be participants reported that the worst symptom was 80 so pretty bad eight out of 10 for severity on their worst days good days bad days but on the worst days 80 out of 100 severe I would call that quite severe now they've tried various interventions these individuals uh in fact they reported immed Med of 20 uh interventions 20 things that people have tried so I think this talks about desperation really they've tried 20 different things to try and alleviate their symptoms because there's no standard treatment this is partly what the study wants to do we need to standardize the treatment for individuals with postvaccine syndrome but anyway let's look at some of the things that they had tried um oral steroids anti-inflam very powerful anti-inflammatory drugs uh 48% had tried that Gabapentin which is usually used for peripheral nerve conditions uh 25% had tried that low dose now treone 20% had tried that drug beginning with I uh 44 18% had tried that propanol beta blocker 11% brona dilators to dilate the respiratory passages 11% have tried that so it looks like they're people's now of course the St we are not saying and the study is not saying that any of these are efficacious not at all no one is advising any treatments here they're just simply reporting that this is what people have tried to relieve their symptoms these are what people have reported that they have tried this is part of the problem we we need a database for what is effective so that doctors can prescribe effectively um more than 500 additional treatments were reported by participants again I think I think this is just showing desperation people were trying many different things limiting exercise or exertion quitting alcohol or caffeine hydration and increased salt intake intermittent fasting again no discussion that these are effective or ineffective it's just reporting what people had tried now the conclusion of the study um in this in this study individuals who reported postvaccine syndrome after covid-19 vaccination had low health status low health status not what we want remember the median age here was only 46 was it 46 I'm pretty sure it was 46 was the the median age uh any yeah I'm pretty sure it was 46 yeah 46 so we're dealing with relatively young people here much of the time with low health status this is not the way it should be the middle years of life should be for the most part healthy for the most part for most of us High symptom burden we complaining a lot of symptoms High psychological stress of course if there's something wrong with you and especially a chronic disease that does lead to anxiety and depression or that could be an intrinsic part of the syndrome that people get anxiety and depression so it could be like a primary manifestation of the syndrome or it could be secondary to all the other things that are going on either way it's horrible and distressing for the individual despite trying many treatments and then the paper says there's a need for continued investigation uh to understand and treat this condition absolutely there is we agree absolutely totally completely with that this needs to get into mainstream medicine now finally I haven't checked this out myself but U this is the um this is the way that the study was um completed through Kindred I think you can probably join this I haven't tried it but I think you can do it uh Kindred is a community of patients working with researchers to power more useful uh impactful progress and there the links there if you want to check that out uh probably able to report your symptoms on there um obvious questions is um why hasn't this data been published by um the bodies that are supposed to monitor this sort of thing yellow card system in the UK V in the United States why aren't we getting papers from the the CDC and the Health Service in the UK but these people at Yale are listening and uh maybe we should just close with that if if someone is suffering from something whether it's physical or psychological listen to them refer them on to professionals as well of course um but if someone says look tell you the truth John whatever whatever whatever you your name is um you know I'm I'm not feeling that good today I'm feeling being anxious today then listen to that because Ju Just to for someone to say that might require quite a bit of um quite a bit of Courage for them to say that you know if someone's a bit depressed and they say look look look look look Joan I'm a bit I'm a bit down today it's probably taken a lot of Courage for them to say that and if you say something like oh don't worry you'll be better soon then that that's kind of almost dismissing what what they've said if someone says that to you take it on board and say oh really thank you for telling me tell me more if you'd like to listen to what people say doctors nurses need to listen to what people say everyone needs to listen to what people say The Human Experience is real and uh we need to to listen to each others and take it seriously and believe people when they report their feelings that's what a symptom is by definition it's something the patient experience is not a clinical sign that you can see like a knee reflex symptoms something a patient reports if a patient reports a symptom believe it unless you've got very firm evidence that it's not true then we need to believe it and that's what this stud is doing it's listening to people and um one of the the indictments of uh healthc Care Professionals over the past few years is maybe not quite enough uh listening but thank you for listening

Channel: Dr. John Campbell

Views: 1,965,278

Keywords: physiology, nursing, NCLEX, health, disease, biology, medicine, nurse education, medical education, pathophysiology, campbell, human biology, human body

Id: -UJqhG1I7tY

Length: 18min 40sec (1120 seconds)

Published: Sun Nov 19 2023