Apoptosis Animation

a key driver of malignant transformation tumor maintenance and resistance to therapy is the impairment of a critical cellular function a puto --ss or programmed cell death abt 199 or GDC zero 199 is a small molecule designed to selectively bind and inhibit bcl-2 a critical regulator of a puto psious bcl-2 is a member of a larger family of structurally related proteins that are either pro a photonic or anti a photonic the dynamic balance between anti a patata members such as bcl-2 and pro a patata family members can determine whether a cell lives or dies by binding common structures shared among pro a patata family members bcl-2 inhibits a puto --ss in response to stress normal cells as well as certain cancer cells will up regulate pro a patata family members in normal cells this increased expression of pro a patata proteins is sufficient to induce a puto sious in contrast malignant cells will often express more bcl-2 to keep pro a patata kembers in check this prevents cancer cells from eliciting and a patata chrous Ponce although increased bcl-2 expression allows the cancer cell to survive under continual metabolic stress the reserve of pro a patata family members sequestered by bcl-2 can leave those cells vulnerable to cell death co-developed by AB V and Genentech 199 is an orally available small molecule designed to selectively bind and inhibit bcl-2 upon binding bcl-2 199 can displace the store of pro a patata proteins in malignant cells this causes a shift in the dynamic balance between the available bcl-2 and pro a patata family members inducing a puto sious with bcl-2 inhibited by $1.99 pro a patata proteins are left free to promote poor formation in the mitochondria signaling a point of no return for the cell cytochrome C and other factors are subsequently released from the mitochondria initiating the caspase activation cascade the activation of these proteolytic enzymes coordinates the ordered destruction of the cancer cell app-v and Genentech are continuing their research into the selective bcl-2 inhibitor ABT 199 or GDC 0 199

Channel: XVIVO Scientific Animation

Views: 49,586

Keywords: 3D Animation, featured, medical animation, medical media, Science, Science Art, scientific animation, XVIVO, XVIVO Scientific Animation, cell animation, scientific illustration, molecular, molecule, small molecule, Abbvie and Genentech, BCL-2, cellular apoptosis, cellular, cancerous cells, apoptosis, mitochondrial membrane

Id: KFhFlElTZ-w

Length: 3min 4sec (184 seconds)

Published: Mon Oct 26 2020