Apoptotic Pathways

the ability of cancer cells to avoid a puto --ss or program cell death and continue to proliferate is one of the hallmarks of cancer and is a major focus of cancer therapy development to signaling mechanisms exists for activation of a proptosis an intrinsic mechanism and an extrinsic mechanism in the intrinsic pathway cell death may be triggered through DNA damage or severe cell stress following activation intracellular pro-apoptotic proteins are released to activate gas phases this ultimately results in a proptosis a process commonly blocked in tumor cells restoring the intrinsic a pro Tata cafe after it has been inactivated may promote tumor cell death the extrinsic pathway is activated in response to diverse external signals such as a po2 L Trail this pathway has the potential to induce death of tumor cells independently of the intrinsic pathway development of novel molecules that promote a puto suspecting both pathways of a proto TSA's intrinsic and extrinsic advances the understanding of the mechanisms behind tumor cell proliferation [Music] genentech bio oncology is committed to developing novel molecules that promote a proto --ss by targeting the intrinsic and extrinsic pathways [Music]

Channel: Genentech

Views: 349,762

Keywords: Genentech, Roche, apoptosis, programmed cell death, DNA damage, p53, tumor suppressor, tumorigenesis, radiotherapy, chemotherapy, DR4/DR5, Apo2L/TRAIL, DISC complex, FADD complex, cytochrome-c, caspase. BioOncology

Id: SyvOPXeg4ig

Length: 2min 4sec (124 seconds)

Published: Tue Nov 13 2012