Watch CELLS AT WORK with a Medical Student | Episode 2 Hataraku Saibou

what is up my Nakamoto so my name is Daniel and I'm a current first-year medical student and is highly requested in the comments section I will now be doing my reaction to cells at work episode 2 and I'm really excited and can't wait to see what this anime it's gonna throw at me in this new episode but before I start I just want to give a huge thank you to all the health care workers who are currently at the hospital risking their lives and protecting people with the coronavirus I think that this is just a selfless and amazing act that they're doing even though it is part of their job they are still risking their lives going out there and treating patients I'm just kind of making these videos as a small source of positivity during these kind of bleak times and I hope you enjoy watching this and I hope this incentivizes you to just relax and stay at home because that's kind of the best thing that we can do in order to ease the burden on the hospital systems so anyways without further ado time to get into cells that worked episode 2 [Music] I love the platelets I wonder for scent pies like a mature red blood cells close to the end of its lifecycle or something so I know it's where to go the platelets again I hope my platelets are this cute [Applause] [Music] [Music] straight food I'm guessing the platelets might be involved in this one [Music] [Music] oh my god that's amazing that's funny they're washing fibrin so basically fibrin it's like the last component of the coagulation cascade so the very last thing that happens is fibrinogen gets converted to fibrin and basically it acts as like a large mesh work that together with platelets forms like a stable clot so it was interesting that the platelets it was they were kind of like washing a giant mesh of a net so I'm assuming they might be getting ready for some sort of cloth or something but that's cool that they depicted it like a like a mesh work the fibrin that inflammation oh my god mmm kinda looks like when pain destroyed the hidden leaf village [Music] Oh was she gonna go into the outside environment she gonna like bleed our she was saved he's back okay I see oh no that's kind of sad some of them are just gone now Deseret the body will replenish it anyways did a foreign substance get in like just insurance oh that's a lot of terms I wonder if it's just like common skin Florida Oh staph aureus oh yeah I mean staph aureus it does like reside in the skin and pores but staff are is can be really really serious especially if you're immunocompromised yeah I can cause like meningitis it's a common cause of pneumonia it can cause some like osteomyelitis as well and arthralgias is that okay we got some hands why what's up going in yeah this is one of the very first things that happens basic instructions yes they said yes so in order to like control the amount of blood that's lost or flowing out it will Basel constricts near the site of injury oh no more germs are getting here streptococcus pyogenes okay so this version of streptococcus elm it's a little different than the strep pneumo from the first episode this is actually the common cause of strep throat but there could be more severe complications depending on if you experience the symptoms after you've had the bacteria for example there's like post strep glomerulonephritis and I believe there is also rheumatic fever which couldn't be caused after having this bacteria but strep pyogenes it's pretty common cause of strep throat you just take antibiotics if you are diagnosed with it and it is a common bacteria of the throat and I think generally what happens is like if you aspirated or if your immune system is somewhat compromised then that's when you will actually see some symptoms of the infection yeah this is awesome they're just coming out with all the typical bacteria so let's see how this goes pseudomonas no okay Pseudomonas could be really bad especially like in a hospital setting it's funny that they depict Pseudomonas like this because it is naturally occurring in like aquatic environments do they say that I guess natural environments but it is I believe terms like hot tub folliculitis no hot tub it's like the hot tub bacteria because that's where it could be found it could be in a source of water requirements but isn't it it is referred to as a common no custodial infection meaning that it can be spread in hospitals and it is a very common cause of pneumonia as well like pneumonia acquired hospital infection and it can be pretty bad depending on how bad the infection actually gets but usually like most of these bacteria that like exists in your throat or in your oral pharynx or on your skin your immune system will just handle it basically so hopefully that's what happens in this episode but you know something interesting actually that they said last episode was the white blood cell mentioned that the host as in like the body that they're in is immunocompromised I think so I wonder if the body that they're in has something wrong with it in general like some sort of genetic anomaly or if the body is just an amino compromised in general because I do remember the white blood cell mentioning something about that in the last episode so I wonder if that will come into play in the future oh no you can't go through the one-way valve yeah they showed that last episode when she was trying to deliver Oh to the wrong way I love the white blood cells white blood cells it's first responders they're super important the story who's this guy whose current economic key to our warrior oh my love it's logic you know the Karate Kid my oh my God he's going in yes the classic halfway point in anime but the rocks a ball pretty deep operation the staph aureus or the nasty bacteria oh my god there's a lot of them oh L selectin um I don't know if I remember everything about that but I believe it's like an adhesion 'el protein that white blood cells can express in order to like adhere to the endothelial layer it's I think it's what they use like when they migrate to like different sites in the body so I think he was telling him like keep your L selected on so that like you stay clinging to the wall and like thrown out as that's what you think q coach you to to discuss your banjo stereo system see look it's got a high pitch the psyche NEMA second you die you're sitting on hey they're not stroke super important in pursuit or your buddy raccoon favor suddenly show up eventually getting intense a man ki dharti sigh Baltimore B sideboard M&IE that's no cure you can ask it oh I think I know what it is I think it's gonna be the platelets we're gonna form the clock GP one B so if I remember correctly GP 1b is something that the platelets expressed that binds to von Willebrand factor which is expressed on your endothelial cells when they have like some sort of damage and basically that interaction sort of causes the platelets to bind and aggregate there to like initially form the clot and like begin the coagulation cascade which is I'm imagining what's about to happen right now oh there we go it explained it for me coagulation factors so that's what those work stay away the fibrin mesh work and this is how you patch yourself up it's like an internal band-aid miss Staphylococcus so it's awesome I should have used this earlier to study now the important thing to know is that you can actually have too much clotting which I believe is called thrombocytopenia wait no I think actually thrombocytopenia is the opposite it's when you can't clot enough I believe it's just thrombophilia basically like you're in you're in a hypercoagulable state and that can cause things like embolisms or deep vein thrombosis basically like you form a clot it can lodge like in the lower part of your lake but then once that travels back to your lung it can form something called a pulmonary embolism and that can be super dangerous because then if you have a pulmonary embolism like you can't breathe and you can't like replace your oxygen stores and have oxygen be delivered for energy through your body so yeah like having a deep vein thrombosis and then having a pulmonary embolism afterwards can be very dangerous and usually requires like immediate hospitalization or some sort of emergency procedure so it is good to have clotting in some sense in order to like prevent you know bacteria from going into the wound in order to prevent excessive blood loss but over clotting can be an issue too so conversely in order to deal with like over clotting there's something called tissue plasminogen activator and basically that will basically cause like anti-clotting activity so it will convert plasminogen to plasmin and kind of license cut the clot TPA tissue plasminogen activator I'm wondering if they're gonna introduce that in this episode but I think they're just focusing on the initial formation of the clot with like platelets and von Willebrand factor and the end product of the coagulation cascade which is converting fibrinogen to fibrin to form that initial like mesh work you saw that kind of acts as like a band-aid Tuscon your plans have been foiled come on open ah no cooked Illinois called out fake friends that's to hype straight hands yeah oh you don't you how do you survive oh he used his um L lectin I see a romance happening it's not the red blood cells job to be and the immune system they're just like oxygen and nutrients delivers said get you well my mo Kuechly yo Cooney cut the kids I think okay tada [Music] it's stuck to the fibrin mesh work so this is bad this is how I a secondary hemostasis so the first fiber network was primary hemostasis but you know too much of the secondary hemostasis and that can be bad because you don't want to over clot as I mentioned before [Music] but yeah this was a really awesome episode it's I love how the show it's it gets everything right and it's very accurate especially like in terms of like how cloths form and how the platelets like use clotting factors and like the fibrin mesh work and how there's like certain bacteria that are pretty like normal like you have normal gut bacteria and you have normal skin flora and bacteria and you have bacteria like living in your mouth and your throat as well the thing is is that unless like you're immunocompromised or you somehow aspirate that bacteria or you develop some sort of like immunoglobulin deficiency usually they are going to be like asymptomatic and cause no problems and actually like bacteria in your gut I mean you need that bacteria to survive they carry out a lot of important physiologic and biological processes that are necessary for our survival and necessary for a lot of like absorption of nutrients and stuff so you know not all bacteria are bad some are good it'll be interesting to see if they introduce like any good bacteria like friends of the human body but yeah this episode was awesome I hope you enjoyed and I hope you keep on watching with me as we continue through this series and as always dr. bio [Music] you

Channel: Daniel Kaganov

Views: 32,773

Rating: 4.9941263 out of 5

Keywords: cells at work, cellsatwork, cells at work medical student reaction, cells at work doctor reaction, cells at work reaction, cells at work review, medical student, medical school, medical student anime review, medical student cells at work, medical student cells at work reaction, cells at work 2020, cells at work bacteria, med student reactions, first year of medical school, anime quarantine, watch with a medical student, hataraku saibou, medical anime, cells at work episode 2

Id: YLLRDir0lEA

Length: 19min 4sec (1144 seconds)

Published: Thu Apr 16 2020