mRNA influenza vaccine

what a warm welcome back still Sunday the 21st of May now we've been looking at this um announcement from the National Institutes of Health on this new uh influenza vaccine mRNA influenza vaccine that's being trialled and that's the original report from the uh clinical trials uh dot gov that gives you the details of that and this is interesting because this is a phase one clinical trial a very early clinical trial and yet the UK government has already agreed to buy uh mRNA vaccines over the next 10 years a thousand million pounds deal with moderna so strange to my mind that the um the deal and a thousand million pounds of British taxpayer money um and similar situations in Australia and Canada in the United States has already gone into this before the trial results are even published this really is quite bizarre in my view that the we have the uh I guess you have this saying in the states as well jumping the gun um is jumping the gun why don't we get the trial date first and then think about giving the thousand million pounds for vaccine Mass manufacturer I would have thought that's the sensible thing to do anyway let's look at some of the uh let's look at some of the detail from this because it really is quite quite interesting so um this is this is a clinical trial of uh messenger RNA Universal influenza vaccine so it's Universal it should act against the claimers all sorts of influential will be examining that and saying it might not be quite what it sounds like it is um clinical trial experimental Universal influencer vaccine National Institutes of allergy and infectious diseases basically all parts of the National Institutes of Health in the United States enrolling volunteers and it's based in uh Duke University Durham North Carolina now it's a phase one clinical trial so very early phase one Trials of course are carried out on healthy uh volunteers just to make sure that the drug is well not to make sure it's okay to find out if it's if it's if it's okay I suspect they are going to find out it's okay um but um I strongly suspect they're going to find out it's okay by their criteria of okayness um but um anyway let's look at it so this is the this is the codes for the vaccine messenger RNA messenger ribonucleic acid and I assume they don't say but that stands for lipid nanoparticle so these tiny lipid particles and as we've seen from the Australian data they can get everywhere all around the body that you're going to check for safety and ability to induce an immune response the number involved up to 50 healthy volunteers 18 through to 49 years of age so this is direct from their website this is not me this is not me having a joke here they are claiming the National Institutes of Health in the United States are claiming that by testing 50 volunteers healthy 18 through to 49 they can assess the safety of this vaccine this is a a parody of research in my view 50 volunteers to test for safety I don't think I don't think so National Institutes of Health but of course you're the National Institutes of Health you know much more you've got lots of clever people working for you let's hope there's no uh vested Financial or political interest whatsoever but the idea that you can publish something on this website here that says there's 50 healthy volunteers and that you're going to test for safety is laughable in my view but hey what do I know let's move on um three groups of 10 participants each I mean this is just tiny they're going to get anywhere they're going to give 10 25 and 50 micrograms doses of the lipid nanoparticles containing the messenger RNA to make the influenza antigen after evaluation of the data determine the optimum dose an additional 10 to tend to receive the optimum dose now how on Earth they're going to work this out I have no idea because this is not directly related to the amount of antigen produced so you could have someone here where these mRNA particles get into billions of cells and they produce huge amounts of antigen someone here if it's just restricted to the arm and there's very little systemic distribution they might make relatively small amounts of antigen this is part of the problem with this technology how do you predict the amount of antigen that's actually produced from a certain dose of Mr mRNA instruction anyway they reckon they're going to optimize the dose so we'll see about that an additional 10 so additional 10. not a big scale trial at all um study to include a group receiving a current quadrivalent vaccine now this is the current vaccine so most of the current influenza vaccines are quadrivalent they've got four different types or four strains of influenza in it to produce some broader type of immunity so they're going to compare it with that they don't say how big this control group is going to be that's another question mark uh there's going to be comparison between immunogenicity and safety of the two vaccines So based on this trial of 50 people they're going to determine the safety of this new mRNA vaccine we shall uh well we'll question that that do feel free to respond National Institutes of Health or was open to talking to you going to be follow-up appointments for up to one year up to one year given this is a new vaccine technology is one year long enough I don't think it is because this is a new vaccine technology I would have thought we need a longitudinal follow-up but hey that's again that's only me annual uh seasonal flu Jabs vaccines um vaccine tool the valuable tool in control and the spread and severity of influenza they say to what degree does it control the spread less sure about that but I'm just quoting from the NH side uh do not provide immunity against every strain of flu so that's true the only chest normally if it's quadrivalent they have four vaccines um and this is the normal vaccine we're talking about now and each year um basically it's an informed guess it's a very informed guess but it's based on a prediction so it's a guess of what um influenza strain is going to be prevalent the following year so you've got to start making this with a lead up time of about a year nine months to a year so they think well what is going to be the forms of influenza causing outbreaks of flu next year let's make a vaccine to predict that and of course that is that is genuinely genuinely a tricky thing to do but they do the best on that with a traditional vaccines then they need time and then the dominant strain of the virus could of course change by then especially if there's something called genetic shift um which we uh which can cause pandemics of influenza as of course we have seen many times and not a non-common event so an effective Universal flu vaccine um now this is this is the acting director who uh I can close um protects its recipients against a wide variety of strains while that would be highly desirable all the different influenza the it to other Universal influenza vaccine would be genuinely a good idea ideally providing durable long-term immunity and that's basically what he says there um a universal influenza vaccine will be a major public health achievement I agree with the acting director and could eliminate me for both annual develop development of seasonal influenza vaccines yes it could if it worked and it was safe as well as the need for patients to get a flu shot every year Well if you had one flu shot and it covered you for life that would really be quite a good idea um he's saying defense uh they're saying defense against spread of a future flu pandemic much less sure about that we know from the covert vaccines that um they weren't preventing transmission as much as people originally thought they were with the influenza vaccine prevent with this new influenza vaccine prevent transmission well that would need to be proved unequivocally in large-scale trials then all I would believe it until then I remain uh open about that open stroke skeptical skeptical both vaccines use a specific uh so this this is another mRNA vaccine they're talking about here so this this particular mRNA vaccine uses a hemoglutinin ha uh stair a Stern part of the molecule not the head part so the head part keeps changing the stern part tends to stay the same so if they produced an effective vaccine against this Stern part of the molecule then yeah that that could work that could that's got the potential to work but as we've already said there's an awful lot of unknowns and as we looked at in the last video I hope you saw that when we looked at this diagram here what we're worried about is systemic distribution of these lipid nanoparticles because they're so small we know that they can actually go everywhere not just stay in the arm as we were originally told with the mRNA covert vaccines but this is I'm not talking about the covered vaccines now we're talking about this new one now as we said we're gone headlong into this technology so this is the British government deal here everyone Smiley and hand shaky there which is interesting the British government uh making this deal with moderna now let's just look at some of the details here as we've said why on Earth would you make the deal before you the technology has proved it's just utterly bizarre I mean of course no one's saying there's vested financial interest between the British government and moderna of course not I wouldn't say that but it is a bit surprising that the deals done before the research has been done I would do the research first then I'd know what I was buying but British government obviously knows more than I do um this this is that paper here um UK cement's 10-year partnership with moderna in major boost for vaccine research the government site this is the UK government site boasts up to 250 million doses a year now in in in Australia that there's a new plant to produce 100 million doses a year and uh also in Canada and of course the production in in the States has already very big British governments put a thousand million into it for starters We Believe committed to buying modernist vaccines unproved undemonstrated unresearched but we've committed to buying it for the next 10 years this is how these people are spending our money buying an unknown technology upfront over the next 10 years it's not me making this up check it out this is on this is on this uh this is on this website there you go um look look it up and these other websites they're giving you here as well always put the links on this channel of course it's now we know it's going to be hard well in Oxfordshire Innovative Innovation and Technology Center is going to be built up and running by 2025. moderna have said this will provide the UK public with access to mRNA vaccines for a wide range of respiratory diseases might provide moderna with a few uh few pounds as well of course which they didn't see that mentioned in the article but maybe it's true and as we've looked at questions how do we control the antigen dose not told how long will the antigen be produced for not told uh what's the degree of systemic distribution not totaled and what's the degree of systemic inflammation not told do watch the previous video where we explained the pathophysiology in a little more detail if you were have an interest in this um I find it concerning that we are going apparently Hook Line and Sinker Lock Stock and Barrel whatever expression you want to use into a new technology which is unproved and we've committed to that in the UK for the next 10 years before these questions about systemic inflammation are answered inflammation wherever it could systemic of course the systemic blood goes everywhere so systemic blood goes to The myocardium systemic blood goes to the lungs systemic blood goes to the brain it goes to the testes and the ovaries it goes to the kidneys and the liver and the spleen obviously these are fundamental questions based on our understanding of the circulatory system which we've known about for hundreds of years identified by the English surgeon Thomas Harvey in the English Civil War quite clearly but the civilizations are known about it even before that Leonardo da Vinci has some pretty good ideas about it this is not new stuff this is not complicated science basic questions which seem to go against what we understand about the basic science and yet seem to be being being ignored one of my current concerns is the fact that science is not taken on board properly or adequately by some government thinking uh it would appear anyway they're the questions let's have complete answers to those when we've got thorough answers to those I can come back and say hopefully you know what my concerns were mislaid everything's actually A-Okay tickets whatever you want to call it um but um at the moment concerned too many unanswered questions too much upfront money too many fundamental biological reasons why this could be a big big problem we've got vaccines for lots of things already why do we need all these new ones why go down the MRNA route exclusively at the moment it would appear we'll leave it there um thank you for watching

Channel: Dr. John Campbell

Views: 505,126

Keywords: physiology, nursing, NCLEX, health, disease, biology, medicine, nurse education, medical education, pathophysiology, campbell, human biology, human body

Id: VUJ7pnw9F3A

Length: 15min 11sec (911 seconds)

Published: Mon May 22 2023