Dramatic increase in Diabetes

well a warm welcome to today's talk it's Tuesday the 4th of July and a very happy Independence Day to all our American friends I think you probably made the right decision now just to let you know if you want to watch today's video or not it's about the increase in the prevalence and the incidence of type 1 diabetes Now the incidence is the number of new cases so there's been actually in the first year of the pandemic it was a 14 increase in type 1 diabetes in the second year it was a 27 increase in the incidence of type 1 diabetes now these are the number of new cases but the thing is once type 1 diabetes has arisen it never goes away people have got it for life and this study is in under 19 year olds so these people are going to have to be injecting insulin for the rest of their lives on a daily basis to sustain life this will be a life essential intervention that they take insulin forever and it needs control and it's it's um it's a life it's a life-changing disease and it's got implications that throughout life and there can be long-term complications so the the import of a 14 and then a 27 increase in the incidence the new cases of the type 1 diabetes is going to increase the prevalence the number of cases that are around for decades into the future so this is really quite a significant finding now let's get straight down to some of the details um so I think this is this is from this paper it's actually from the uh Jama Journal of the American Medical Association so well respected peer-reviewed work systematic reviewer meta-analysis just published at the end of last month a lot of the work comes from Toronto but they took papers from all over the world so they looked at a lot of European data a lot of North American data and this is an international Trend that's happened during these two years now has this trend been increased in the third year of the pandemic we don't yet know if it has it really is becoming quite alarming because this is a great burden of morbidity into the future for all the individuals concerned and of course the economic costs as well and this is bad in in every perspective really so we need to get to the bottom of this and find out what's causing it to try and stop it so key points 42 studies uh over a hundred thousand youths involved all under the age of 19 and as we say that means they're going to have this disease for a long time into the future incidence of type 1 diabetes was Hydro in the covered pandemic compared to years before the pandemic the findings suggests the need to elucidate possible underlying mechanisms to explain temporal changes so the temporal changes are the increase in the first and second years of the pandemic why is that this is a direct quote from the authors we need to find this out so what is going on here why is there such a dramatic increase and how can we stop the incidence of new cases in the future the cases that we already have medical science at the moment cannot reverse them we can only manage it through lifelong insulin Administration unfortunately um synthesize estimates to change in incidence rate so they took all the different studies put it all together and they worked out these new incident rates around the world now um the minimum observation period for the study was 12 months before and 12 months after so they could compare the prevalence or the incidence rather of diabetes before the pandemic and after the pandemic and they also looked at this condition d k a now dka is diabetic ketoacidosis it's what happens in type 1 diabetes if people don't have their insulin so unfortunately some people with type 1 diabetes who develop it it's not picked up at an early stage it's picked up at a slightly later stage when people already have this diabetic ketoacidosis which is bad because it's a serious medical condition and it's also bad because people that have diabetic ketoacidosis on presentation are often more difficult to control to control their blood sugar levels into the future and so it looked at that as well so the results for type 1 diabetes incident rates while the qualifying number was 38 149 youths throughout the world first year of the pandemic the risk was 1.14 so that's a 14 increase during the first year of the pandemic and the second year of the pandemic it was even worse so the first year of the pandemic of course is 20. 2020 and this is 20 uh 21. 20 7 increase this is really quite a huge increase in type 1 diabetes Now for type 2 diabetic well just before we say that um the expected rate now there has been an increase this is European data the rate of type 1 diabetes has been increasing in Europe This is European data in this particular instance three to four percent increase for the past few years so we would expect it if this trend had been followed at three three to four percent increase but we got a 14 and then a 27 increase this is statistically significant it's a huge increase why had it been increasing up to this time different reasons type 1 diabetes is an autoimmune disease the immune system attacks the beta cells in the pancreatic islets insulin is only produced in these beta cells in the pancreatic islets one of the reasons might well be that uh children are too clean this so-called hygiene hypothesis lack of bacterial challenge in early life but there's other factors there's genetic factors this early life diet there's lack of breastfeeding so it had been increasing anyway but now we have this dramatic increase way more than we would expect which is the key thing we're talking about today type 2 diabetes I think most of you probably know the difference type 1 diabetes is typically juvenile onset though not always but type 1 diabetes is autoimmune destruction of these beta cells so there is an absolute deficiency eventually without insulin these people with dark will die type 2 diabetes either the insulin is not used properly or the body doesn't produce enough insulin typically these there is a condition called insulin resistance in type 2 diabetes normally occurs later in life but not always when type 2 diabetes occurs in children it's usually a combination of a genetic predisposition and a very bad Ultra processed food diet often combined with lack of exercise so the type 2 diabetes there was an increase but the study really didn't have enough data to quantify that so there's no figures for that but there is some increase in type 2 diabetes also concerning dka the increase in diabetic ketoacidosis 15 studies were able to qualify for that and again there's a 26 increase in that so why was there an increase in diabetic ketoacidosis being admitted two hospitals around the world and part of this could be because the diabetes was picked up late because of covert restrictions and medical problems but it's also possible that the type 1 diabetes that we're getting is having a more acute onset that's presenting as diabetic ketoacidosis rather than the classic symptoms such as a thirst polyurea increased volumes of urine so thirst increased volumes of urine weight loss and tiredness are the classic early features so bear in mind if young people are getting uh large volumes of urine thirst unexplained weight loss of unexplained tiredness it should be checked for their blood sugar levels and medical advice taken accordingly the authors conclude from this further studies are needed to assess whether this trend persists let's hope it doesn't but the data we have for the first two years of the pandemic is not good and this may help to elucidate possible underlying mechanisms that's what we need to find out what's happening so that's basically the story this is a concerning rise in the incidence of type 1 diabetes that will be with us for decades into the future unless some dramatic cure is found but there's nothing likely to reverse type 1 say type 2 type 1 diabetes um there's nothing likely to reverse type 1 diabetes in in the pipeline at the moment this is going to go on for the rest of these individuals lives and that is a concern we need to find out what is causing this um the fact that there's been so little attention on this is surprising um but there again we've learned to be disappointed with mainstream media I think haven't we let's go and give a few more details for those that want it um some studies reported an association between SARS Corona virus 2 infection and new onset diabetes so is this caused by SARS coronavirus to infection well it's very hard to tell because um the this challenge in SARS coronavirus 2 diagnosis most children of course who develop type 1 diabetes were simply not tested for SARS coronavirus II so the authors say direct quote there is concern about the validity of these studies so um the authors are not accepting on Face Value the fact that SARS coronavirus well the the question as to whether SARS coronavirus 2 is causing more type 1 diabetes data sets used for other studies did not capture asymptomatic SARS coronavirus too so of course um perhaps well I think we can say pretty well all of the children in the world have been exposed to SARS coronavirus to the vast majority of them or virtually all have been infected by SARS coronavirus too um so it's not surprising that the people the developing type 1 diabetes have had SARS Coronavirus um because it's everywhere so we can't really take much from that and the other thing this is the thing that's really important to me the authors say this there's no clear mechanism by which covid-19 that SARS coronavirus 2 active infection could directly or indirectly lead to new uh type one or type 2 diabetes so what the authors are saying here well some people have said that SARS coronavirus 2 can cause one diabetes but we don't accept the evidence for it and um and uh there's no mechanism by which it would no no mechanism by which it would cause type 1 diabetes although we will be looking at a possibility shortly if you want to stick around for a bit more detail so purported direct mechanisms SARS coronavirus too um entry receptor so the ace2 receptor is on the insulin producing beta cells right now this is important to me what we're saying is that the beta cells the pancreatic islet beta cells the pancreatic eyelets of langerhan as we used to call it the beta cells in there do have these H2 receptors on the beta cell and of course it's the H2 receptor that fits in the spike protein fits into so the spike protein regardless of where that Spike protein came from that can fit into the ace2 receptor site on the pancreatic beta cells now the question is does the spike protein fitting into the ace receptor the Angiotensin converting enzyme receptor site on the the surface of the beta cell does that in some way damage the beta cell and start off an autoimmune process of Destruction in that beta cell um it's an open question but we certainly have the damage that the potential the physiological potential for Spike protein damage here they do say direct quote there is no clear underlying mechanism explained in the association between saskar and advice to infection and subsequent risk of diabetes and yet we have this ace2 receptor which is amenable to the spike so it does sound a little bit like they're contradicting themselves here I think they are leaving the mechanism the door open for this possible mechanism of Spike protein damage population-based studies suggest that the increase in the incidence may be due to immune mediated mechanisms so the authors looked at population-based studies and said well there could be an immune mechanism here and this makes sense because the destruction of all the beta cells and therefore the eradication of insulin producing capacity in the body um is an autoimmune an immunological disease where the beta cells are all immunologically attacked and of all the immunological attacked beta cells die off over time as they do then there's nothing left to produce insulin we have this absolute deficiency of insulin proposed Direct effects of the covid-19 sorry proposed indirect effects of the covid-19 pandemic um and containment measures may be associated with diabetes now this is contrary to what we expected based on the decreased viral infections amongst children so what this is what this is saying is that is postulated that some type 1 diabetes is caused by intercurrent viral infections but given that children reliably locked down in the early stage of the pandemic they would have less interaction with other children therefore less exposure to these viruses therefore would expect the beta cells to be less exposed to these viruses therefore we would expect less type 1 diabetes not more this is the opposite of what we would expect we would expect lockdown effects to reduce type 1 diabetes but we're not seeing that so is it some other Factor that occurred during the pandemic that's causing the increase in type 1 diabetes rather than these mechanisms because lockdowns in theory should reduce the amount of type 1 diabetes and catch up given that there was a delay potential delayed diagnosis well it's pretty obvious when children develop type 1 diabetes but that would only affect the first year of the pandemic and as we say in the second year of the pandemic the increase in incidence was 27 percent so that does not explain it so there we go some Mysteries to be explained but we do know that the beta cells have an ace receptor which could be affected by the presence of Spike protein more research desperately needed because the implications of this are simply huge for the individual and ongoing for as we say many decades into the future so urgent research required I sort of want to say about that for today now just before we finish um Tim has written in who who's an expert in in microbiological uh um Warfare and things like that and uh yesterday day before we did we did a video looking at the um origins of SARS Coronavirus 2. and I concluded that I I was sure this wasn't a deliberate biological warfare agent and I still believe that um because human beings are capable of making biological warfare agents viruses that have have a very high lethality but Tim's written into um and I'll I'll put the details of Tim's argument in the text at the bottom is written in and just see if you can follow this quite interesting Reflections on yesterday's lab leak video and biological warfare so Timmer says this as someone who has spent a number of years studying biological warfare and ways to defend against it I'm not convinced that the Wuhan virus virus was not meant to be a biological warfare agent now we're not saying it was but this is an argument to say that it could be I'm not convinced that the Wuhan virus was not meant to be a biological warfare agent High lethality isn't necessarily required to Be an Effective weapon it just needs to be able to incapacitate a significant number of people the incapacitated people are no longer able to do their jobs and the added benefit to the employer of the weapon is that those incapacitated people now take up more resources and more people to treat them than if they died and I know this is the case with some biological warfare gases they're not designed to kill you they're designed to incapacitate because that means the incapacitated person can no longer fight but it might take two other people that could have been fighting to look after that uh wounded person this is of course how cynical weapon design is um Tim goes on also the genetic techniques that they used techniques that made it difficult to identify any man-made changes so we looked at this the the there seems to be a deliberate track covering attempt here to cover man-made changes techniques that made it difficult to identify any man-made changes is in line with one of the main attractions of biological warfare and here we have the phrase plausible deniability so it's plausible deniability and we've seen this phrase so many times around the world in weapons being supplied so um I put that I will put that um I'll put that this is this is Tim's reasoning here I will put it on the um on the notes underneath because I think it's a very good uh but very simple um very simple uh explanation of a possibility and we have to be open to all potential lines of discussion and evidence and reject some but leave others out on the table so we'll leave that one open and renew our call for Urgent investigations into why there is um a 27 increase in 2021. of the incidence of new cases of type 1 diabetes I mean I mean I've been treating type 1 diabetes all my life this really is quite concerning it's an ongoing ongoing issue and the complications of diabetes and yet this huge increase quite concerning really anyway let's an even more it's also concerning that more is not being discussed about this you're as up to date as I am on that thank you for watching

Channel: Dr. John Campbell

Views: 438,842

Keywords: physiology, nursing, NCLEX, health, disease, biology, medicine, nurse education, medical education, pathophysiology, campbell, human biology, human body

Id: GRohIT7-aik

Length: 19min 58sec (1198 seconds)

Published: Tue Jul 04 2023