DNA Damage Response

every year 1 million women all over the world suffer from breast cancer a healthy breast consists of different cell [Music] types in the nucleus of the cells you can find the DNA every day the DNA of each cell is damaged thousands of times if only one strand of the DNA is damaged this can be easily repaired pop proteins bind to the damage and attract other proteins that repair the [Music] damage when damaged DNA duplicates before the damage is repaired a double strand break can arise in a healthy cell this more severe damage can be repaired with the help of homologous recombination brca1 protein binds the loose ends of the DNA and starts to unravel the DNA [Music] strands using the undamaged DNA strand as a template the damage is then [Music] repaired finally the two strands are separated leaving both DNA strands error free [Music] free in patients with hereditary breast cancer the brca1 mechanism does not work when a double strand break arises in the cells of these patients the DNA cannot be repaired the persisting damage can cause cells to die but it can also transform a cell into a cancer cell this cancer cell is the start of a tumor in which all cells have the same [Music] defect in this patient specific treatment an inhibitor of Pop is being used the inhibitor reaches the tumor via the [Music] bloodstream and inactivates the pop [Music] proteins when a single strand break arises in the DNA of the tumor cell it can no longer be repaired the persisting single strand break can transform into a double strand break because of the hereditary defect in the tumor cells the brca1 protein cannot repair this damage causing the tumor cells to die in the surrounding healthy cells the repair mechanism of single strand brakes is also inactivated by the parp inhibitor the cells however still have active brca1 proteins which repair the double strand brakes and allow the cells to survive as soon as the parp inhibitor is removed after treatment the repair of single strand brakes is reactivated by that time all tumor cells have already been [Music] killed DD response towards a new treatment for breast cancer

Channel: Nymus 3D

Views: 4,009,039

Keywords: Nymus3D, Demcon, 3D, Animation, animatie, Enschede, cells, cell, division, medisch, science, wetenschap, research, visualization, visualisation, breast, cancer, dna, damage, repair, protein, parp, healing, tumor, erasmus, european commission, health, ddresponse, bloodstream, Nymus, DEMCON Nymus3D, DEMCON Nymus 3D

Id: 2yI_SoOWFMU

Length: 3min 38sec (218 seconds)

Published: Mon Jul 17 2017