Alternative facts

you're very welcome to today's update now i hadn't planned on making this talk at all i had something completely different in mind but i've had lots and lots of complaints from from many of you about this and here it is here so this is the video i did yesterday where we compared pfizer's new covered medication and we suggested it shares uh pharmacodynamics that's the mechanism of action or modulate modality of action with ivamectin and i actually went to quite a lot of trouble on on this paper i actually went to did quite a lot of a background reading on it and i think i gave evidence that it was a similar modality of action or at least to one of the modalities of action of either mexican yet many of you who who kindly posted the link from my video got this on facebook so we'd clearly been um independent fact-checkers ah so okay so this could mislead people see why so let's indeed uh see why and see what we make of it as many of you have asked me to do so uh cy takes you through to this link here uh psi check or the size site sounds scientific doesn't it factcheck doco.org so and here's the full article here quite detailed now in the past when i've been fact-checked i've actually had bespoke articles made out just addressing my videos which i was quite flattered about to be quite honest to me i've looked at those in the past but this one's much more generic in in nature so let's let's just look at this briefly so the article is called uh merck pfizer covered 1990 vials differ different from ivermecton okay so we will be saying yes and no to parts of that so how are independent fact checkers selected on facebook is interesting so there's a bit of blurb on that there and actually if you go on to the site here this is all public domain this is live straight live from the facebook links you can actually see the fact checkers and who they are so i'm not going to go into the details of the the personalities of the people that are actually writing this and this is attributed to one author it's easy to find out just click on it and you can find the link um but let's look at who they are so first of all um this one um i'm not going to go through the names as i've said they're there if you want them the first one is a journalist so here we have one of the fact checkers is a journalist and uh it tells you about the background of this journalist it didn't look particularly scientific to me now the next fact checker um the these people that uh arbitrate what is true for the for the hoi polloi like you and me who who can't really tell the difference it's really good that these people are able to tell us what is fact from fiction and what's facts and what's alternative facts so uh are the second ones are journalists as well so uh that one's a journalist also uh this next one is a professor of communication so professor of communication now strange thing to be a professor of i would have thought communication but but there you go um but it's not medicine is it and it's not science so it's how you communicate with people i guess i'm not really sure what communication means in that context but oh the next one is a journalist um that one's a journalist this one's a journalist this one's in a form a former assignment header so i assume that's kind of like a senior journalist i don't really know this next one now this is the only one actually is a science journalist and actually the the person that uh critiqued uh or not critique but did the comment we're about to look at is actually a qualified uh phd level scientist but that was the only one in the list who i could see was a proper scientist so we'll give her a tick this other one one earned a ba in journalism or a ba well lots of people have ba's i mean i've got one myself you know i mean i mean many of you watching will have a a bachelor of arts degree um you know they're quite uh they're quite common it's no particular big deal um just a bit of work or quite a bit of work my mind was but uh but you know it's not it's not that impressive uh the next peer reviewer here worked as a reporter i guess that's the kind of journalist he's a graduate of the school of journalism so he's a journalist is a journalist so it looks like the new arbiters of truth who keep the likes of you and me informed are mostly journalists and a professor of communication uh and and a former assignment header and editor and one of those is a um one of those is a sign is a science a qualified scientist who is now a journalist so these are the people that decide for us kindly um what is true and what is not what are the facts and what aren't the facts so um just to remind us um factcheck.org this is this is the logos they put out psi check digest so so what we have here is we have a group of how many people that are read out there i don't know about eight of them or nine of them or ten of them or something and one is a scientist and yet these are the side check digests so i guess psy is the first three letters of science i guess that's what they mean so anyway what are they saying the pills are very different from the anti-parasitic medication ivamectin so just uh reminding us that ivamecten is an anti-parasitic medication which we already knew of course but the pills are very different now i assume from this they mean the mole new peruvian capsules we don't know if the new fisa ones are pillow or capsule yet or not this is the new fizer one here which we looked at and this is this is quite normal to have a a sort of a research name here on this is the investigation on medication as a protease inhibitor and we know we looked at protease inhibitors because we gave evidence that either mechanism was a protease inhibitor that blocks a key enzyme in the size coronavirus too virus needed to replicate itself and this was it here in fact this was our um three uh chymotryptin like protease that cut up the long proteins into shorter proteins in fact i think i might still have the through flying around here yep here we are um so here we had um a long protein that was cut into two shorter proteins by uh my pair of scissors i mean by the three uh chymotryptal protease but we couldn't now because it's inhibited it's inhibited by this bit of taper on the end that stops it working that's the protease inhibitor so that's what we did yesterday and and then we get a logo as we go down um just to remind us that this is a scientific process here we are here it is here look so we get this uh side check just in case we've forgotten this as a scientific process as we go down now first of all mull new peer review which we talked about a few days ago roughly about 50 efficacy of people keeping people about keeping people out of hospital right while the results of um well the results have not been published in a peer review so they haven't so these are not this is not a peer-reviewed medication they're talking about they were compelling enough for the trials independent data monitoring committee to recommend an early hold to the recruitment of the study now many of you in your feedback said given that this is a new antiviral it might have been better just to let the study run for a bit longer because this is a single study and the medicines and healthcare regulatory authority in the uk seem to have approved multnomah peripheral on the basis of one which you could say truncated um clinical study which amazed me actually quite i found that quite incredible that they'd approve that on the grounds of a a semi-completed study so quickly food and drug administration in the states uh that they're considering the application on the 30th of november so that's going to be a bit more time yet now mondo pirivia is a nuclear side analog so that in other words it's similar to one of the bases in rna the four bases in rna a drug that messes now this is a direct quote from the from this uh this is a direct quote from this scientific report and it's a drug that messes up viral replication by tricking the virus into using the process medication as one of its building blocks for its genetic code this let's be clear this is a completely utterly different modality of the function of ivormectin and we were quite clear about that uh when we recorded the video on this no ambiguity it's nothing to do with ivormectin modality work in completely different ways so they are correct the capsules of privia work in a completely different way giving more information about mondo preview the the this this paper goes on or this article whatever you want to call it goes on um this is what's known as error catastrophe using a mechanism called lethal mutagenesis so error catastrophe so these these dodgy bases are put in and uh it causes lethal mutations a mutation is a change in the genetic material of a cell or in this case a virus we hope it's a virus lethal mutagenesis now that sounds absolutely fantastic if that is the virus that's being affected i don't like the sound of error catastrophe or lethal mutagenesis if it's affecting human cells and i have said that even though the mhra has recommended this and even although the uh the press release and it is a press release from merck said that this wouldn't be a problem i'm waiting for the peer-reviewed data on that before i make my judgment not so i can make a judgment not that i'm so smart i can judge from the peer-reviewed literature but when it's published in a peer-reviewed data of a peer-reviewed journal millions of doctors and scientists around the world can can review it and we'll get not just one or two opinions but literally a million or two million or three million or four million or 10 million informed opinions from doctors and scientists around the world until then i am not going um until then i don't have the rationale to explain why the medicine healthcare regulatory agency in the uk made the decision they made so we'll wait for that although both drugs are novel uh with news of these development people on social media are spreading false notions that the pills are the same or suspiciously similar to either mechtin well again as we've said that one probably has the same mechanism of action one doesn't so i mean i don't see that i've said anything wrong so far to get this fact check anyway some interrelations of the claim uh incorrectly posit that pfizer's drug is based on ivormectin that the two are essentially the same because they are both protease inhibitors well as far as i understand it i gave a lot of evidence that they were both protease inhibitors um so um the we we know that the uh that the new fisa drug is a protease in it but because the uh the press release tells us so it must it must be it must be right um so that's protease inhibitors uh something that's not been established even if it's true doesn't mean the drugs are similar so this this fact check article is telling us that it's not been established it's not been established that ivamectin is a protease inhibitor and even if it's true it doesn't mean the drugs are similar well if it is true actually it doesn't mean the drugs are similar because it means they work in the same way it means that they both uh inhibit three uh chymotryptin-like protease mustard because the scissors are stuck so so um yeah okay now i don't want to disappear down the rabbit hole here but we we let's go with this argument because it has it has got some validity now the paper that's talking about here a a com computational model paper published by some indian scientists this is this is only published by some indian scientists so it's probably i'm sure there's no implication there that just because it's published by indian scientists it's less valid but it's just written in a funny way um but then the the the author of this is right that these are uh mostly in silico analyses molecular modelling and and she says however this does not show that ivormectin acts as a protease inhibitor in sars coronavirus2 through any sort of biological experiment it only proposes the possibility based on computer simulations well this is essentially true so she is quite correct to point this out the examples we gave were based on um detailed computer modeling uh events but there is this this paper here if i put that one up no i'm not sure yeah i think i think that's that one is it um drugs shown to inhibit so i was gonna yeah yeah um yeah i think that's that one um that one there um that paper there which we've looked at in the past um so this um that this one actually tells us um it's talking about ivan acting as a re-purpose of as a therapeutic occasion for covert 19 after in vitro studies that that is in in uh in test tube studies uh which were critiqued criticized for not having showed that uh there's a five thousand fold inhibition of sas coronavirus too the debate here is about the concentration of course but so so while the uh author of this critique is right in saying that um there is no in vitro evidence of this precise modality of action there is other in vitro evidence of uh antiviral activity so we could i guess we could give a half for that now the mechanism of action of ivor mechton against chronovirus through an evidence-based critical review journal of antibiotics now this is from the journal of antibiotics uh which we have here so that's from this article here journal of antibiotics 15th of june 2021 looks like um well it is a pretty thorough article now what this one is saying um this article while it doesn't give any new evidence it's basically reviewed the literature and seems to accept it seems to accept that ivormectin is a 3cl inhibitor once that's enzyme 3 carbotryptin like protease inhibitor is responsible for working on this polyprotein which is the long protein that's chopped into smaller bits so it fits into the virus causing other proteins to liberate and carry out viral replication i have a mechanism binds to this enzyme and disrupts it so this paper here um basically seems to accept it now while it is true that this is based on in silico analysis it seems to be accepted by the journal of pharmacology but i'm happy to concede the point that the data for ivamectin being a protease inhibitor although multiple multiple studies have shown this they are simulation studies but this is what you would expect with molecular function so if we take another molecule for example if we take this molecule here p f naught seven three two one three three two oh come to think of it that's the new ivormect that that's the new um pfizer medication isn't it so the new fisa medication the very medication itself um the way that we know that or the way the only way that's in the public domain that we know this is a protease inhibitor is from you've guessed it in computer in silico modeling uh exploration the binding mechanisms of the new fisa medication size coronavirus to protease inhibitor through molecular dynamics and building free energy simulations and the crystalline structure of i guess that mean kind of means the 3d structure really the crystalline structure of the uh 3cl protease inhibitor in the in in complex with this one that the new fisa drug are not yet available therefore the docked complex of in other words the combination of the new drug and the uh and this the protease inhibitor was generated using molecular operating environment software so that's kind of in the in the same in the same boat really so i guess if this drug was a person would say to it people in glass houses shouldn't throw stones so um that's where we are with that so it's a partly valid criticism i think it's a partly palliative criticism but i don't think it alters my fundamental contention that i've met in one of its functions according to these pharmacodynamic in silico studies is that it functions as a three cl protease chymotryptin like protease inhibitor there's a few interesting bits from this before we finish i'm not gonna go on today um looks like merc is repackaging the horse drug and making it much more expensive it will be the new treatment for corona vice and pill form now that's a quote from this article um so that's kind of putting up what's being said on social media now this is what we call um i guess this is what you call a straw man argument you put up an argument that people are saying that you can easily knock down like a straw man's it's not too difficult to i'm not sure whether why they call it a horse drug though i really don't know why that happens given that ivamectin has been given to 3.7 billion doses of biomechanical given to human beings it's funny horses are given antibiotics some of the same antibiotics is given to humans and we don't we don't say well you know i went to the doctor today and he gave me a horse drug he gave me amoxicillin it's a horse drug no it's a human drug horses happen to take it as well it's just bizarre it's really quite bizarre the food and drug administration has warned people again self-medication with uh easier to access formulations of vitamix infor livestock which are highly concentrated and also may include other ingredients that have not been tested in people absolutely we agree totally absolutely that gets lots of ticks completely correct and i believe we've actually said this many times on on our videos so i'm not quite sure why being fact checked on that particular point as a result there is no basis for claiming that either the pfizer or merck drug are similar to why from acting in any way well yes the merc drug it's not similar in any way uh the the pfizer drug does seem to be a protease inhibitor so i would give that i'll give that statement five out of ten if i was marking this paper pfizer also denies any connection this is a spokesman this is a spokesman from pfizer according to this article also denies any uh connection fires of protease inhibitor is not similar to that of animal medicine i wonder what animal medicine they're talking about there and i wonder why a fire is a spokesman he's calling a drug that's been given 3.7 billion doses to humans in animal medicine if he is indeed referring to white rebecca that's a bit strange that he wants to come on the channel and explain that of course he's very welcome um a company spokesman said in an email very strange thing to say uh the post uses the phrase of pfizermectin i'm saying on me but um anyway that that's um that's actually a direct quote from this from this uh from this critique which i thought was was quite interesting um yeah that that last article i showed you from uh the where where that new medication works in the has been the modality of action has been analyzed in the same way is there that's that paper there so i think i've given as much evidence as i can on that um now in full disclosure that they do claim that um editor's note side check covered 19 max vaccination project is made possible by a grant from the robert johnson wood foundation johnson that that name's familiar i think that's the same johnson has started johnson and johnson the huge international pharmaceutical company uh correct me if i'm wrong on that but i'm pretty sure it is now um there we go so uh uh am i a bit annoyed about being fact-checked well maybe i suppose you could you could say that uh no not really it's not it's not annoying it's just it's just a big giving argument and counter argument which of course i'm always happy to receive so um hopefully that's clarified the position on that now um it's not that i'm mischievous or naughty but i'm just going to give you one fact before we finish this analysis uh final fact this is not an alternative fact this is a genuine fact no i think i didn't i don't think i meant more than a pirate there i think i think i think i meant flu vox flu vox me now i'll check on that tomorrow but fluvox flu voxamine the antidepressant we've looked at also has flu flu for three fluorine atoms as does the new medication there i'm pretty sure i meant flu voxers in there i put the wrong drug but that's just me being uh being mischievous to point out that there's a similarity between the new physical drug and fluvoxamine which i'm not qualified to speak on but i i'm pretty sure they both do have three fluorine atoms not that that means that much really to be quite honest so there we go um quite a few of you asked me to do that i hope that helps um i think i think the thing is you know um the idea that some people set them i think the thing that's a bit annoying really is some people are sort of setting themselves up over the rest of us as fact-checkers and we have to sort of sit at their feet and say oh thank you for distributing a few facts um i guess that's the current uh big tech phase we are in so a bit of a left field video today let's listen to richard in london who's going to give us a report richard thank you very much hello dr campbell this is richard in central london i've just got back from my booster jab only an hour ago at a university college hospital in central london and uh it was a fisa jab it has been exactly six months since my second jab which were both astrazeneca i was in group six which is uh the vulnerable group because i had an out of hospital cardiac arrest because of my wolf parkinson white syndrome you can describe to your viewers what that is if you like um and a successful ablation but that is monitoring me so i'm in group six which is fine um and so i went in and uh everything was in order and i asked the nurse whether she could aspirate uh the needle and she said uh she'd never done that kind of thing before um and then she asked with a smirk have you been reading things on the internet um and i said well yes that and the lancer and the british medical journal and other locations and that seemed to um uh pipe her down a little bit and so she said okay she will go ahead and aspirate and so uh i believe she did but foolishly i've got a bit of a nervous thing with needles and so every time a needle goes in i always look away and so i didn't actually watch to see if she did actually aspirate or whether she said she wouldn't you know did it behind my back but literally um but uh it seemed to be very quick but uh i trust her and i presume that it was aspirated but yes but there was a there was an energy that suggested that i was you know a bit of a tinfoil hat wearing nutcase for even thinking that an aspiration was needed and also a little bit weird that this i was the only person who's ever asked her but uh it's been it's been an hour now as i say and i'm feeling fine um having had astrazeneca and then uh having a pfizer afterwards i've been warned that there might be um some side effects for a couple of days and they suggested having paracetamol but i remember a long time ago you're mentioning that uh having paracetamol and cooling the body temperature down isn't necessarily the best thing to do when the body is trying to put its temperature up to a fever-like state to be able to um fight the virus um but maybe you can elaborate more on that after this and so yes just thank you um dr campbell for all of your videos i've been following them faithfully uh since the start of this hell and so um i wish you all the best and please make more videos thank you thanks so much richard um really really very uh really very uh eloquent uh report um very con very concisely put it must be said so thank you for that so so richard had this condition called well he had an out of hospital arrest so pretty serious i'm just so pleased that there was facilities there to resuscitate you fully richard that's brilliant wolf parkinson white is where the the impulses go from the top of the heart and they go through to the bottom of the supposed to but then there's another pathway which allows the impulse to go from the bottom chambers of the heart back up to the top so instead of just getting an impulse going through every every uh 70 times a minute or whatever it is you actually get one going through then it goes back quickly so you get a very quick recycling and that means that the ventricles are stimulated very quickly and that can cause this uh condition called ventricular fibrillation so delighted you've had that ablated that the pathway for that will have been ablated by the cardiologist so it's just basically won't exist anymore i think tony blair had something similar when he was a prime minister actually so really pleased that that's worked out well the idea about the paracetamol um i think what we have to understand is fever is the body's natural response to a uh to an infection or in this case i guess to the immunological response generated by a vaccine and we should think carefully before we obliterate the body's natural physiological responses to anything whether that's inhibiting diarrhoea or inhibiting coughs or giving an anti-metic to keep vomit in the stomach when it wants to get out we have to consider these things carefully and uh i think there's no real debate that paracetamol it's acetaminophen or tylenol in the states is is over used so delighted you're doing well uh richard thank you for the report um do feel free to update us and uh that's all for today thank you for watching

Channel: Dr. John Campbell

Views: 596,775

Keywords: physiology, nursing, NCLEX, health, disease, biology, medicine, nurse education, medical education, pathophysiology, campbell, human biology, human body

Id: ObTAOvgd_JE

Length: 27min 26sec (1646 seconds)

Published: Thu Nov 11 2021