[ ♪INTRO ] Chances are that you or someone you care about
has experienced depression. It’s one of the most common mental health
problems in the US. Around 16% of American adults will suffer
from depression at some point in their life. Given how much we talk about and treat depression,
it might seem like we’ve got it figured out, from a scientific perspective. But we do not understand as much about it
as you might think. Especially what’s actually going on in your
brain when you’re depressed. Doctors have defined depression, or at least
agreed on a set of criteria to diagnose it. The Diagnostic and Statistical Manual for
Mental Disorders, also known as the DSM, is the handbook healthcare professionals use
to diagnose mental disorders. And the latest edition of the DSM lays out
two key symptoms of depression. The first is feeling sad or depressed. But many depression sufferers experience this
more as a lack of feeling, or numbness, rather than sadness. The second is a loss of interest or pleasure
in activities that are normally enjoyable. You have to have at least one of these key
symptoms, as well as 3-4 additional symptoms consistently, to be diagnosed with depression. Additional symptoms can include unpleasant
things like: feeling worthless, difficulty sleeping or sleeping too much, difficulty
concentrating and making decisions, or suicidal thoughts. Not all of your symptoms need to be severe,
but as a group they can make it harder for you to function at work or school, in your
relationships, or just in life. We know that depression isn’t simply a bad
mood that you can snap out of — something is not functioning correctly in your brain. The question is what? One widespread impression among the public
is that depression is caused by having too little serotonin. But that’s an oversimplification at best. Serotonin is a neurotransmitter — a chemical
that neurons use to signal each other. When a neuron signals its neighbor, it releases
a neurotransmitter, like serotonin, into the synapse — the space between itself and its
neighbor. The serotonin molecules diffuse across the
synapse and bind to their receptors on the neighboring neuron, transmitting the signal. Then the signalling neuron reabsorbs — or
re-uptakes — its serotonin. Some of the most commonly used medications
for depression are selective serotonin reuptake inhibitors, or SSRIs. SSRIs reduce the reuptake of serotonin, which
increases the amount of serotonin hanging around synapses. But how these medications work and sometimes
don’t work show that a lack of serotonin isn’t the only thing happening in the depressive
brain. If that were true, you’d expect that SSRI
medications to work pretty quickly, and to work for everyone with depression — but
they don’t. Even though serotonin concentrations may go
up right away when you take an SSRI, it can still take weeks for people to start feeling
better. That is, if they even start feeling better
at all. SSRIs simply don’t work for all patients. Research has identified a few other potential
factors that could help us better treat depression. First off, serotonin isn’t the only neurotransmitter
that plays a role. Research has shown that at least 5 other neurotransmitters
could be involved, all of which serve many different functions in the brain and elsewhere
in the body — it’s complicated! And the structure of our brains matters too
— not just the chemicals inside them. Certain regions of the brain, and the connections
between them, have been shown to be altered in depression. The amygdala, which helps us process emotions,
and the hippocampus, which has a role in memory storage, are among the brain regions that
undergo structural changes in some patients with depression. Changes like having a different size compared
to people without depression, though we’re not sure what that means exactly yet. And rather than merely changing the levels
of certain neurotransmitters, studies have shown that antidepressants can actually help
new neurons grow in certain parts of the brain. Which may be one reason why SSRI medications
typically take so long to work. Your brain could be growing new neurons, not
just responding to a short-term change in chemical messengers. There’s likely a genetic component to depression
as well. There is some evidence that depression can
run in families, though the association isn’t particularly strong. A 2018 genome-wide study sampled a huge pool
of genes in people with and without depression. It found 44 variants that seem to be associated
with depression. These so-called “genes of interest” included
genes previously shown to have a role in the growth of neurons — as well as some surprises,
like genes previously shown to be involved in immune system function. But it’s unlikely that a particular gene
or genes cause depression on their own. More likely, it could be the result of how
your personal set of genes interacts with your environment and your experiences. Some studies have found that variants in certain
genes can interact with major stressful events in childhood to affect the rate of depression
in adults. But not all studies find such strong links
between our genes and our environment. It’s still an active area of study. So depression is hard to figure out. There are so many factors involved, and they
all interact with each other — from genetics and environment, to the chemistry and structure
of the brain. The good news is that even though we don’t
entirely understand how depression works, we still have ways to treat it that help lots
of people. You don’t have to know exactly how an existing
medication or treatment works to know that it does work — that patients may respond
to it and feel better. Meanwhile, scientists are still working to
tease out the many, intertwined causes of depression to develop new treatments. So there’s hope on the horizon. Even when you can’t see it. Thanks for watching this episode of SciShow
Psych, which was supported by our community of patrons. To learn more, check out patreon.com/scishow. [ ♪OUTRO ]
