What is Design of Experiment (DoE)? - Video Explanation - METTLER TOLEDO - EN

[Music] chemical processes in the pharmaceutical and chemical industry are often affected by multiple parameters called CPP's critical process parameters making it difficult to find the optimal conditions quickly and efficiently rather than adopting a trial-and-error or one factor at a time approach scientists often applying the design of experiments methodology the statistical do a method is a multivariate approach and aims to determine the relationship among factors affecting a process and the outputs of that process by varying a number of potentially influential factors simultaneously factors are varied from their lowest to highest value and all combinations are executed in the same set of experiments for example in the case of a three factor do-e the values can be represented in a cube where the corners represent the eight test conditions thus experiments are carried out along the respective space additional experiments are performed at the central point and points between the low and high factors to determine the intrinsic variability and if there is curvature of the response surface subsequently a mathematical model can be established to display the responses graphically from the contour plot one can read the relationship between the factors and the responses in order for the deal we approach to be regarded as a success it is essential that any experiments are performed in a systematic way within an accurately controlled framework under reproducible conditions therefore the requirements for the experimental setup the experiment itself and the execution are high and demand a high degree of flexibility precision and reproducibility from the synthesis tools with which the experiments are carried out to learn more about automated synthesis reactors for do-e check out MT com / ez max [Music]

Channel: METTLER TOLEDO AutoChem

Views: 17,409

Keywords: METTLER TOLEDO, Lab instruments, what is, Design of Experiment, DOE, OFAT, EasyMax, organic chemistry, trial-and-error, synthetic organic chemistry, learning, Critical Process Parameters, factors, experiment, mathematical model, quality by design, how to improve design of experiment, process chemistry, synthesis reactor, DoE, Dosing, Temperature, pH, DoE Studies

Id: Srq9Q-yd1Rk

Length: 2min 3sec (123 seconds)

Published: Mon Jun 03 2019