Understanding NASH (Non-Alcoholic Steatohepatitis)

[Music] the liver has many important functions within the body including roles in metabolism detoxification digestion and the production and regulation of several hormones for example the liver is responsible for maintaining blood sugar levels through the build up and breakdown of glycogen a key energy source for the body the liver also plays an important role in fat storage and metabolism liver fat can arise from numerous sources including delivery from fat tissue in other parts of the body and the creation of new fat from foods high in fat and sugar if fat buildup and removal is unbalanced it can lead to an abnormal amount of liver fat accumulation called steatosis factors such as obesity type 2 diabetes insulin resistance metabolic syndrome and a genetic predisposition can lead to metabolic changes in the liver causing excessive fat accumulation non-alcoholic fatty liver disease or nafld is a spectrum that includes simple fatty liver and non-alcoholic steatohepatitis or nash nash is a progressive form of nafld developing in about 20 percent of nafld patients when the excess of liver fat is accompanied by cell ballooning inflammation and cell damage nash often progresses slowly with no obvious or visible symptoms as nash progresses it can lead to liver scarring known as fibrosis fibrosis severity is measured on a scale ranging from no liver scarring or f-zero to cirrhosis or severe liver scarring at f4 as nash progresses without detection and intervention in earlier stages severe and irreversible liver damage in the form of cirrhosis liver failure and even liver cancer may occur in some patients pfizer is committed to advancing the science and understanding of nash to uncover potential treatments for people impacted by this serious condition by restoring the balance of fat buildup and removal in the liver through lifestyle changes such as healthy food intake and exercise and hopefully one day with new medicines bad accumulation can be reduced in many patients reducing or eliminating fat accumulation may help minimize or even reverse the inflammation injury and scarring associated with nash reducing risks of cirrhosis liver failure and liver cancer [Music]

Channel: Pfizer

Views: 40,880

Keywords: Pfizer

Id: dbKVkse3pI0

Length: 3min 6sec (186 seconds)

Published: Mon May 16 2022