This DOCTOR Knows What Causes Alzheimer’s and How You Can PREVENT It | Jay Lombard on Health Theory

but I think what people most forget is that the the the closest proximity uh of infectious diseases to the blood-brain barrier is in periodontal uh diseases and that's been strongly associated with with Alzheimer's disease everybody welcome to another episode of Health Theory I am joined today by Dr Jay Lombard Jay thank you so much for joining me today it's a pleasure to be here thank you dude I'm really excited to go into this um you are bringing together a lot of different things in your field I'm used to dealing with holistic people when it comes to nutrition when it comes to um metabolic Health but you're sort of the first person I've come across that's bringing similar areas together when we look at neurological conditions and so as a I guess a flag post here for everybody in the audience we're going to go on a pretty epic journey I think today regarding what impacts the brain negatively some of the neurological disorders that are cropping up like mad and what we can do to fix them and let's get really specific about what your core hypothesis is and it'll be interesting to see because there's actually for how impressive I find you there is precious little um interview material out there on you and so I could watch your thinking evolving in real time as I you know watch these interviews and so the sort of last guidepost that I had in terms of what you were talking about publicly was that hey I think that we what we may have is um uh pathogenic problem in the gut that is making its way to the brain through leaky brain and that may be causing I mean you you very specifically said I have a hypothesis that ALS is caused by um C diff and that was as as of last guidepost was the thing that you said that people were really pushing back on and I'm curious is that still where you're at or uh well it's evolved since then so I'm glad to have this interview right now because I I think C diff uh uh one of the issues with uh correlating infectious disease with neurological diseases uh is is there's two questions basically the first question is uh are they comorbid conditions not necessarily being causal I mean that you can see patients that have infectious disease like C diff uh it doesn't necessarily mean that that those infectious diseases are causing neurological problems so one of one of the gaps in our understanding is how specifically do infectious diseases actually lead uh to neurological injury that's sort of you know one big step that has had evolved in my thinking uh to establish you know uh I won't say the word causality but but pathogenic mechanisms that overlap between infectious diseases and neurological problems and the second thing that I I kind of have to backpedal on I thought that it was C diff was the primary Smoking Gun uh that's why I'm glad that I'm on this uh call with you today because I don't think it's a single infection I think it's a multitude of chronic infectious diseases uh whether it's a combination of bacterial fungal as well as viral diseases Lyme disease I'm going to listener to my patients so my patient's telling me that there's a connection between uh when they developed a herpetic infection or a Lyme disease and they have to develop you know MS symptoms uh I started paying attention and not being dismissive of What patients told me they thought the connection was between infectious disease and a neurological problem yeah so if your former hypothesis and and you were very clear that this was a hypothesis and every time I've ever heard you speak you're very metered which I love but I also like that you're not afraid to have a hypothesis that you're pursuing so is now you're thinking that basically that we're getting these neurological symptoms we think that we need to focus entirely on the brain but really the effects in the brain are merely a uh a symptom of a pathogen that has intruded somewhere else whether it be from a tick bite and its Lyme disease or whether it be from your diet and your you've caused disruption in your microbiome and now C diff overpopulates is is that the idea that all of this is pathogen related or is there potentially something else yeah so first of all I'm glad that that uh that this is a hypothesis this is a theory right and it's it's it should not I do not want to be credited for this Theory I mean there's plenty of Publications from nature from all sorts of esteemed journals that have actually asked this question you know is Alzheimer's an infectious disease uh another neurogenic disease is Parkinson's so I I don't want to take credit for this Theory uh that's number one number two is I think that the way my thinking has evolved regarding this hypothesis is to try to explore how specifically does any infection uh produce neurological problems so my in regards to how my thinking is involved I think that these conditions are ultimately vascular based meaning that uh inflammatory conditions infectious diseases uh bad lifestyle insulin resistance hypertension all converge on the endothelium on on blood vessels basically in the walls of blood vessels and that is sort of the underlying mechanism of neurological injury that connects all these epigenetic factors to neurological diseases like ALS Parkinson's and Alzheimer's disease so you know in the old days back uh you know in the 1990s when I finished my neurology residency we would see on on MRI studies when they first came out because it was you know that in those days MRI was just being introduced we would see all sorts of of changes ischemic changes changes like like what we call mini strokes uh or vascular changes uh in various areas of the nervous system so for instance in Parkinson's disease patients we would see you know evidence of what's called small vessel ischemic disease uh what does ischemic mean he means lack of blood flow Interruption of blood flow and we still see these changes if we do uh MRIs on Alzheimer's patients who are in patients with ALS we see what would call these unidentified bright objects these ubos uh that the Radiologists uh kind of comment on and they they say differential diagnosis could be vasculitis it could be Lyme disease it could be just age-related white matter changes but what what all those things actually mean in principle is that whatever the provoking factor is whether it's inflammatory mechanisms infectious mechanisms uh or some combination of various uh interruptions traumatic brain injuries another example that can produce these vascular changes uh the The Smoking Gun if you will is really based upon disruption in these very very small blood vessels that are responsible to perfuse the brain because without perfusion of the brain you could take any supplement you want uh but if you don't have adequate perfusion uh uh you're not going to have a healthy brain meaning you no longer have the functioning vasculature to get said supplement to the regions of the brain that actually need it exactly so all neurodegenerative diseases whether it's ALS Parkinson's Alzheimer's are characterized by the production of of proteins that are misfolded so think of these proteins as basketballs that need to be inflated a certain uh volume so you can dribble correctly right once once that that basketball becomes deflated as a protein we call these misfolded proteins so they really they really are two challenges uh in our approaches to ALS and other conditions one is to uh figure out how to block the production of these proteins because these proteins will continuously be misfolded uh based upon genetic abnormalities that a person has acquired as a result of these conditions and the Second Challenge is once those misfolded proteins are actually um uh created how do you degrade them because these proteins are pathological and they build up like atherosclerosis in fact we now there's plenty of evidence right now uh that these conditions uh you know ALS Parkinson's uh and Alzheimer's disease uh have these plaques uh in the vascular system there's a condition called amyloid angiopathy which which speaks to that so in other words the way I the way I've been thinking about uh neurology right now is the way that I think cardiologists began thinking about heart disease uh back in the 70s meaning that that you know unless you're at the stage where you need surgery right to remove whatever plaques are building up the best bet is identifying who has these conditions number one uh and number two uh putting a full-scale preventative program uh with the same risk factor management as we do for cardiovascular disease because like you said you know the the pathology manifests based upon where a person's most vulnerable people with genetic risk for Alzheimer's that's where this pathology is going to show up but the pathology itself is very similar I mean you know misfolded proteins are basically what clots are right clots are basically protein aggregates that are misfolded and therefore can't be removed by the body's immune system so uh what I mean to say is that I think that you know our our goals here are to to manage these as chronic diseases I tell people my goal as a clinician is to help you live with ALS not die from the condition that's that's what I you know try to encourage people to think about very interesting so do you think that all of these chronic diseases whether it's cancer whether it's heart disease Alzheimer's ALS do you think that they all have um what I was going to ask is do you think they have the same set is probably the right word of underlying conditions or do you think it's just that the body only has so many uh make or break mechanics and things impact those maker break mechanics in different ways that's that's a fantastic question by the way fantastic question so I think that we need to understand sort of uh a little bit more in depth about how the body normally handles these proteins because there are uh cellular mechanisms uh within our cells that are endogenous mechanisms that help us break down these proteins it's an area of the cell called the lysosome which is a very acidic environment that takes a degraded protein and literally breaks it down so that it's no longer pathological basically you know the body has to find a housekeeping effect to essentially dissolve these pathological proteins so a lot of uh leading investigators in all sorts of fields Cardiology basic science of Cardiology basic science in oncology basic science and neurology have identified lysosomal failure meaning an inadequacy of the ability of lysosomes to degrade these pathological proteins regardless of what disease a person particularly has meaning that there's an overlapping mechanism of reduced ability for our bodies to break down these pathological proteins do you think that is due to the amount or due to the type of misfolding that maybe the lysosome doesn't understand because when I think about things like that in our body I I am truly dazzled that there is a part of our body that goes I know I recognize you you're a good protein I'm going to leave you alone oh you look weird you're damaged in some way and now I'm going to dissolve you because they have to be selective so is the system just being overwhelmed or is there a way to misfold that is due to a modern lifestyle that the lysosome is just not familiar with uh it's a combination of various things so uh the the proteins responsible to identify misfolded proteins are called heat shock proteins these are proteins that are elevated by hyperthermia so that's sort of the original principle of why hyperthermia may be an efficacious biophysical approach uh to conditions like this by elevating these heat shock proteins um because those are the the chaperones that say hey you're a misfolded protein it's time for you to leave the cytoplasm come with me to lysosome don't worry we're not going to get rid of you who's going to recycle you uh so these heat shock proteins take uh the misfolded protein they send it to lysosome the lysosome then digests the protein breaks it down then it sends it to the What's called the endoplasmic reticulum which is another cellular structure that helps to kind of recycle all those Pathways so this sort of of a combination of a sort of a three-hit hypothesis is one that there's not enough heat shock proteins because aging itself uh uh and you know one of the things that that I think I spoke about on with Dr Hyman is one of the things that is a very classic history I hear from patients is that they're unable to mount a fever uh very often you know oh yeah I've had C diff where I've had you know lime I've had sinusitis but I never get a fever that means that the body's endogenous mechanisms to increase heat shock protein 70 are defective then you have a second hit which is that the lysosome so think of a lysosome like as a as a pool right and you have to put just the amount of chlorine in the pool or salt if you're not into chlorine right uh but if you put too much salt in the pool uh your eyes are going to burn meaning that if it's too acidic uh that's also unhealthy for the cell but if you don't put any salt into the pool you're going to have overgrowth of mold overgrowth of these various uh infectious diseases in fact one of the most interesting things I just recently found in my research is that bacterial infections actually inhibit lysosomes they actually inhibit lysosomes part of their survival mechanism uh is based upon inhibiting the enzymes that are normally required to digest them because don't forget take me to the swimming pool but the pool is not going to kill me that's exactly right yep wow sure take me to the pool but you know what guys I'm gonna hang out here and that and that's what sort of creates the the chronicity of infectious diseases is that the lysosome is unable to digest them properly because the immune system is saying hey okay we found you know something that doesn't belong to human DNA this is you know bacterial antigen or fungal antigen uh you know A protein that doesn't look like us okay great the heat shock protein has to uh bind to that particular pathological protein right if the heat shock protein uh is not elevated enough because a person can't mount a fever then the infection will remain because it's not able to be character the lysosome but let's say it does take it to the lysosome the lysosome says hey guys I'm out of acid I have no more enzymes uh to degrade this this protein so you know you're looking at at many pathological steps uh in the pathology of these conditions that are that are disrupted uh and and why you know my research is so focused on trying to figure out ways of actually improving the immune system by enhancing lysosomal function wow okay so I've heard of heat shock proteins a bazillion times I have never heard anybody explain what they do only that this may be the reason that saunas are connected I'm not even sure if people are making the Bold claim that there there's a causation but that they're connected to lowered risk of um heart disease yes do you think that's why I I think it's definitely why and and the other the other thing I want to bring up because you know everyone is sort of you know uh kind of puts this gut brain problem uh into things like sibo uh or dysbiosis or you know um you know hyper permeability of the gut but I think what people most forget is that the the the closest proximity uh of infectious diseases to the blood-brain barrier is in periodontal uh diseases and that's been strongly associated with with Alzheimer's disease uh it's it's you know the the oral cavity is directly proximal to the sinuses uh of the brain so that anywhere we're gonna see a leaky mucosal barrier it's in people that have periodontal disease because that's the the first area of of staging of the battle between these various infectious diseases and the immune system so what happens is that the immune system is activated right to try to break down these pathogens and by the way I used to think because I'm not a dentist I used to think that you know periodontal disease is all bacterial but in fact uh periodontal disease has association with candida uh fungal infections uh it's it's not just bacteria that if that causes periodontal disease but the point is that that they're so close to the blood-brain barrier that they have an easier ability to migrate into the brain and produce inflammatory reaction in the brain then leaky gut does so I think that you know one of the take-home messages I would have for your listeners is that yes I think that leaky gut uh is is a very important aspect of you know a functional medicine approach to any condition but I think the first and foremost point of assessment uh would be assessing periodontal disease in those patients wow okay we're starting to understand some of the mechanisms that are causing the issue here how does one improve their oral health like is this just what you eat is this better brushing and flossing like what do we actually need to do so uh it's it's uh both a simple question and a complicated question to answer because obviously you know uh I'm not a periodontist so I don't want to speak out of turn about you know how to match periodontal disease but um you know I think that the first point is yes uh you know oral hygiene is critically important uh there's lots of various types of mouthwashes and like tea tree oil for instance which has you know very good antimicrobial effects um so I think that uh you know a strategy that both includes you know very good oral hygiene but also some type of of natural antibacterial um mouthwashes uh really makes sense to me as well okay so now going beyond the mouth what are we doing on a lifestyle basis to live as optimally healthily high cognition avoid things like Alzheimer's like what do we need to be doing I think people should watch your show more often that's my my first recommendation um good advice you know so um I I think that you know first of all people should you know identify uh whether they have these risk factors right so if people have a family history of of cardiovascular disease or you know heart disease or or lung disease uh uh inflammatory diseases or neurological diseases they're the ones that really need to pay attention uh to preventive strategies going forward I mean we all do obviously but we know that those people have a high genetic risk because their family members have had similar diseases so you know Ben Franklin said an ounce of prevention is worth a pound of cure right so I I think the same recommendations that we have for cardiovascular disease are are equally warranted for prevention of neurological conditions there are there are two uh phenomena that regulate epigenetics okay so regardless of what Gene you have because everyone everyone has bad genes for for something right I mean you know this old workup you know what's a healthy person someone who has a full diagnostic work up yet right we all have you know genes that are going to lead to something down the road uh but epigenetic expression uh is modified by two processes one is called methylation uh which is why you know high doses of methyl folic acid have proven to be very effective in a variety of clinical conditions like depression uh but also the second process is called acetylation so methylation and acetylation are able to kind of repress uh pathological genes from expression but people have done a lot of uh work on the methylation processes but there's much less understanding of how nutraceuticals and certain pharmaceutical agents promote what's called uh inhibiting the deacetylation the breakdown of acetyl groups that are responsible to prevent the pathological expression of a bad protein think of a mummy right uh the mummy's got all this stuff wrapped around him right uh the the methylation and and acetylation help to keep that mummy Under Wraps once what's under the wrapping is our DNA correct the expression of the DNA correct yeah what do you mean the expression so in in the what my Layman's understanding of DNA goes like this it's this tightly wound thing and depending on how much it's wound any given Gene is wound up will determine its level of expression so when a Gene gets turned on by something in our environment that loosens the winding and now that Gene can be read and therefore it expresses now I get that that's probably super clumsy but if that's sort of a rough idea is that not then inside the wrapping is our DNA correct so what's what wraps the DNA is something called chromatin uh uh which is just the way it keeps it basically regulates the expression of genes right so and by the way just as a shout out to what you just said so there's many non-pharmaceutical uh nutraceutical compounds that prevent uh the deacetylation the the breakdown of the Mummy wraps to help uh prevent the expression of pathological genes uh some of this work was done by Andy Zimmer who's uh a pediatric neurologist I think he was at Hopkins at one point that demonstrated that um certain isothiocyanates from broccoli and from uh other uh healthy foods um actually uh have um neuroprotective Effects by actually preventing the expression of pathological genes in autism all right this is uh man this stuff is so complex but the fascinating thing is the more I interview amazing Minds like yours I I'm actually starting to piece this stuff together it's pretty crazy uh okay so all right so you were explaining epigenetics and how those were the two elements of epigenetics and we were ultimately trying to get to like what those lifestyle things are that we can do that are going to make sure that we don't end up expressing um some you mentioned autism now and I do want to get into that but first I want to sort of finish this lifestyle aspect um I I've heard you talk about ketogenic so I know you have um familiarity with at least the byproduct of certain diets I'm curious to know like where you come down on uh veganism versus carnivore and things like that like do you have a take on what lifestyle gives us the sort of optimal results yes regardless of whether you live it or not that I'm not worried about that full disclosure right uh no so I I practice fasting on a regular basis um the only reason why I do it though is not not because of the health issues because I'm so busy that I have no time to eat uh from like six o'clock in the morning to like eight o'clock at night so I think fasting is one of the most healthy things people can do as long as they don't have you know diabetes or or you know a risk of developing hypoglycemia oh let's see if the lay person can really get himself in trouble here so if somebody came to me and said I have diabetes I would say the first thing you need to do is fast and you're saying that that is a dangerous answer it could be because if they need to have proper amounts of glucose in their bodies uh they can actually have you know a fair Fairly serious consequence of having too low blood sugar but in just in in a you know a broader uh Spectrum what fasting does uh is it actually increases heat shock proteins um so it's why are they called heat shock ah very good question uh excellent question by the way so what happens when a person is under stress or when a plant is under stress right uh the plants also make heat shock proteins uh it's it's really the wrong word heat shock proteins they're basically environmental shock proteins meaning that that extreme temperatures of either kind hot or cold will activate those proteins but anyway so fasting I think is a great idea um I am very much uh a a believer in protein-based uh vegetarian protein-based diets as opposed to sorry real fast before we move off of fasting the one thing I want to know when you say fast you're talking 16 hours 24 hours 48 hours like what duration do you then consider to fast and not just being a space between meals um I usually start fasting uh like around six o'clock uh at night and then I will eat something very light for breakfast and then I won't eat anything again for until dinner time and the reason that it's healthy is that it produces less stress uh particularly on the liver which is you know primarily responsible uh to metabolize the proteins that we ingest and one of the problems with the high protein diets not that I'm against high protein diets but that it produces a lot of stress on the liver to actually uh you know to break down those proteins properly and if the liver is impaired in some way uh when a person has a high protein intake that may increase something called ammonia uh which is a byproduct of protein metabolism so you know one of the the ideas here is that you know by resting the hepatic function uh through less consumption of of you know Foods on a regular basis reduces something in the body called ER stress endoplasmic reticulum stress which is at the level of the liver so you know by the way a lot of a lot of patients that I see have evidence of fatty liver in association with uh neurological diseases which is why I'm very encouraged with something I mentioned uh with Mark Hyman on the last podcast I did about tutka tutka is a secondary bile acid that promotes hepatic metabolism that is being shown to have potentially beneficial nerve protective effects in a variety of of conditions like ALS very interesting okay so we're we know we're doing fasting you were about to say then what we want to eat what do we want to eat right so I I generally uh recommend the following a third a third a third a third of protein so think about like uh three-fifths of food on your plate uh one fistful should be against my opinion only uh vegetable based proteins um two are you know high quality fats from you know nuts avocados uh olive oil those those types of foods and then the third from complex carbs like you know fruits and vegetables that are very colorful that contain a a wide variety of what are called polyphenols uh which are the things that like broccoli cauliflower are able to uh repress pathological genes through the process we've discussed as well as folic acid okay so what would be um what would be a complex carb that that though that is the one at least for me that I have found just essentially avoiding so would like where do you fall on sweet potatoes which would be my favorite but I find that I put on fat when I eat them right uh what are your thoughts on that or do you have a better complex carb that you recommend no I think sweet potatoes is an excellent look I strongly believe that if nature produces these types of foods right grapes artichokes uh sweet potatoes onions cauliflower uh you know that these that have you know complex carbs as part of their uh makeup that they're not they're not unhealthy it's just it's you know it's unhealthy or or simple sugars not complex carbohydrates uh that produce insulin resistance going forward so I I strongly am a proponent uh of those types of dietary factors being incorporated into it so basically the punch line there is if you're eating Whole Food you're probably fine but where you're going to get yourself into trouble is when it's been processed and the sugar has been refined out and then added back into something is that accurate correct and the same thing is true with with meats and fish as well because you have to look at not just the the the uh the the the the quality of the food but the processing process that goes from you know from Farm to Table that has to be looked at as well yeah one thing that I never thought would matter is what your food ate yep absolutely the same thing is true for fish by the way as well I think we we pay you know not enough attention to to fish as a as a source of of course of omega-3 fatty acids which are essential uh but many fish uh people that consume a lot of fish may have high Mercury uh as a result of consuming fish um so it's you know like everything else uh in life uh these kinds of issues are very very complex uh uh and there's a lot of variables that go into those decisions uh for each person that decides to follow whatever diet that they want to follow so I'm I'm not you know to be honest with you I'm a traditional physician uh I you know usually refer people to a dietitian for questions about what I think is is optimal dietary approaches to to these conditions um so uh but I have sort of a broad understanding uh about what I think are the proper uh dietary consumptions that a person should have in general Jim I'm sad that you don't do more interviews uh I will say that you are not a traditional clinician uh and I think what you're saying now is and I I completely understand and because I'm so much more ignorant than you I am so comfortable making guesses and drawing conclusions um but while I get that you're not a dietitian and all that and you're you know hedging your bets about those aren't my areas of expertise what makes you so amazing dude is the way that you're pulling these different threads together and saying there might be something here you need to look at that there might be something here and so for instance if I were diagnosed with ALS tomorrow you would be my first phone call if for no other reason then you're looking at things that not a lot of other people are looking at and so tying this now sort of finally back into lifestyle um how do you think about these sort of hopeless neurological cases that for like autism in fact let's let's go with that one that for so long people just threw their hands up and you know once it happens it happens and there's nothing you can do and it's purely genetics how do you think about a problem like that uh let's talk about ALS I've moved into a dimension uh in my mind and in my practice uh that where where people who will not give up hope uh uh and and believe that that whatever condition that they have whether it's Parkinson's or or ALS or you know I see some of the most difficult cases in the world to be honest with you and what I find most humbling uh to me as a physician uh is their sense of of not accepting nihilism uh and their their sense of purpose uh because many times I've I've heard my patients say to me that I feel that Parkinson's is a gift and I'm like really I mean I would I would be so angry at at God if I got you know Parkinson's or ALS I don't know how I would come to accept that uh as a condition but uh they've done studies and we've actually looked at people who've had uh long-term survival from ALS who had given a prognosis of like three to five years who is still living uh and I've spoken to some of those those particular folks myself uh and I want to give a big shout out by the way to a non-profit called Everything ALS that has really helped the community of ALS patients uh realize that that we're not going to go down without a fight on their behalf so everything ALS is just you know an extraordinary organization uh that is working towards uh the ability to to not accept the therapeutic nihilism uh that comes with the diagnosis of ALS um and what the common thread of of long-term survivors has been a sense of purpose and Faith uh in the ineffable whatever you could you can call it God you can call it a higher calling you can call it it doesn't have a name basically but it's a sense of of a spiritual connection to oneself and and and the rest of the world that helps them endure uh uh as a mind-body method of helping patients uh deal with these conditions um and it's something that you know I'm glad you reminded me about because that's sort of you know where I come from as a clinician uh is is based upon trying to uh you know for my in my own life to come to accept that that whatever problems that we have are are to learn from those problems to to grow as individuals and to and to deal with them uh without running away from the problem itself yeah that that to me is sort of the Nexus of um why I'm so fascinated by you is really bringing these disparate worlds together so right before I do an interview I always Journal essentially on okay what is it about this person that's interesting or unique or fresh and that was the thing I kept coming back to you with you is there's nobody else that's like pulling these threads together like up until this moment of the interview no one would have any idea that you have this sort of breathtaking expansive view of um God and our brain and sort of the connection they're in because you're still utterly motivated by evidence and science but yet I could have in this interview flipped it and this could have been totally about faith and meaning and purpose and you would have been just as eloquent um and I don't know there's something in that for me in the open-mindedness that has allowed you to escape the nihilism which I find useful and I think is really important but then we get into uh connection and Love and Hope and where do you come down on that and do you think about that as a clinician every second of my life every second of my life um you know love love is is is is is biology basically right uh when we love we increase our endorphins which helps us to uh bear whatever pain that we're experiencing with whatever condition uh my experience with people who have conditions like ALS uh who have very strong social support uh through their families and and their and their friends uh have much much better uh prognoses than the same patient same age same condition uh without those social support systems and you know just a quick aside Victor Frankl who wrote a book uh he was a he was a psychiatrist who wrote a book about uh logotherapy was it was uh what he developed uh he found evidence-based uh that people were able to endure the worst conditions and the Holocaust if they had a sense of purpose they said look I'm going to survive this no matter what because I know at the end it's not going to be reunited with my my kids or my my my my my parents and the people who had lost hope completely uh died uh so the idea that that we can Infuse medicine with a sense of of purpose um is I think of extraordinary value uh you know for everybody to to appreciate yeah yeah it's uh I don't understand it I don't know why it's true but it is experientially self-evidently true right and right you know reading man search for meaning by Victor Frankl was an utterly transformational book for me and I just thought wow like to think about how there is something some connection between the brain and the body where when the brain no longer has a sense of purpose in all of this you actually shut off biologically yes and I wrote about that in the book by the way I mean there's actually explanations about how that happens and why that happens as well give it to us so there are growth factors in the brain uh their proteins uh that are called neurotrophic factors like bdnf is one example uh which by the way is what exercise promotes and why exercise has an antidepressant effect is because it increases bdnf levels but there's a direct uh association between experience uh and cellular Pathways that results in a inability to produce adequate amounts of these neurotrophic survival factors there clearly is a biological explanation for how uh existential states of hopelessness uh lead to you know premature death and how existential states of living a life of purpose are able to overcome uh those on a biological basis meaning that it's not like a game of smoke and mirrors there are explanations about how that actually occurs biologically yeah Jay you are so intriguing to me I am so grateful that you took the time to meet with me today uh you you are hard to find on the internet but where can people connect with you uh well I have a a website that's pretty you know not a great website but it is what it is it's www.drj lombard.com I highly recommend that people uh follow you that they go to your website read your books um I have thoroughly enjoyed my time researching you and spending time with you today uh really really amazing man thank you again for taking the time likewise I've enjoyed speaking to you as well thank you guys trust me while he doesn't put out a lot of social content this is somebody the content that's out there is breathtaking really intriguing and I highly encourage you to check out his books as well watch this interview on a loop and then hopefully we will get him back again someday and speaking of things that you should do on a loop if you haven't already be sure to subscribe and until next time my friends be legendary take care thank you guys so much for watching and being a part of this community if you haven't already be sure to subscribe you're going to get weekly videos on building a growth mindset cultivating grit and unlocking your full potential

Channel: Tom Bilyeu

Views: 186,287

Keywords: Dr. Jay Lombard, Mind of God, Health Theory, Tom Bilyeu, health, impact theory, interview, how to improve your health, alzheimer’s disease, vascular dementia, neurological disorders, neurodegenerative disease, degenerative neurological disease, neurological diseases, neurodegeneration, degenerative brain disease, ALS, periodontal disease, epigenetics, pathology, proteins, misfolded proteins, misfolded proteins diseases, leaky gut, leaky brain, blood brain barrier

Id: aCTTpFnSsD0

Length: 42min 58sec (2578 seconds)

Published: Thu Jul 29 2021