Restoring Brain Function with Coconut & MCT Oil: Alzheimer's Case Study · Dr. Mary Newport · #112

[Music] well the immediate action is fuel that it provides an alternative fuel to the brain to glucose and the brain instantaneously can switch from using glucose to ketones the apparatus is there they've looked as early as the 12-week fetus you know the enzymes everything's in place to be able to use ketones and it's still there in people with Alzheimer's and I think the immediate response we saw with Steve was probably probably related to fuel welcome to the HV MN podcast your resource for evidence-based nutritional strategies cognitive performance and Fitness science thank you for joining us this week fat is fuel that's a common saying within the keto community this podcast episode focuses on how the statement applies to the brain you may know that in fact fat cannot be directly used by the brain but if fat is converted into ketones then it makes excellent brain fuel this is important because as we age and in some diseases the brain can no longer use glucose effectively so could ketones be useful as an alternative source of fuel that is the genesis of dr. Murray Newports story doctor Newports husband Steve battled with Alzheimer's disease until 2016 the time of his passing during Steve's battle his condition responded dramatically upon the consumption of exogenous ketones particularly from coconut oil and ketone esters dr. Newport often described the response as seeing the light come back on in his eyes Jeff and dr. Newport discussed the proposed mechanism of action behind her husband's treatment with exogenous ketones what to look for in coconut oil and MCT oils and what the root cause of outsiders really might be dr. Mary Newport thank you so much for taking the time to come on to our program oh you're welcome it's nice to see you Jeff yes great to actually see each other I know we've spoken on the phone a number of times so great to actually connect alive right you play a very interesting important role within the whole eggs I just ketone space I think you know one specific highlight is first authoring one of the seminal ketone ester case studies on the application towards Alzheimer's patient your husband and might that might be the first entry point that we should kick off the conversation mom I know you're a doctor by background but not necessarily a key to an expert per se how did you get into the ketogenic space and in your story there my story in that regard goes back to 2008 so I'm a neonatologist so that's a physician that takes care of sick and premature newborns and I practiced in newborn intensive care units for thirty years in Florida so far afield from Alzheimer's but my husband Steve developed early onset Alzheimer's with symptoms starting when he was only 51 years old and you know it just continued to snowball and we got to 2008 so seven years later and he was really on a downward spiral and we were pretty desperate and there were very few clinical trials available and he wasn't qualifying but then two drugs came along that you know he could try out for and he was scheduled two days in a row and I happened on a press release about a medical food that was going to come out in about a year that turned out now it's called acts ona but it was still being studied and it said that it improved the memories and cognition of nearly half the people with Alzheimer's who took it and didn't say what it was what it did so I found their patent application online and I learned all of this really interesting research about Alzheimer's as the type of diabetes of the brain that there's a problem of insulin resistance getting glucose into brain cells and if you could provide ketones as an alternative fuel to the brain that that could potentially improve people with Alzheimer's disease so I was fascinated and I knew what MCT oil was this product was MCT oil medium chain triglyceride oil because I had used it in the newborn intensive care unit in the late 70s early 80s we used to add it to the feedings of our tiniest preemies and then they started adding it directly to the infant formulas and they still do today medium chain triglycerides are in human breast milk babies go into ketosis when they're born if they're strictly fed and ketones help build the brain they become building blocks of the brain for the newborn of the lipids and cholesterol in the brain and also provide fuel they need an amazing amount of fuel to fuel that very big brain the newborn does and you know so very important in the newborn and so I thought okay well this is something I could do you know for him and I didn't know I could get MCT oil over-the-counter and I learned that it was extracted from coconut oil so the first thing we did was actually used coconut oil which is the richest source natural source of medium chain triglycerides so it just happened that he had a day before and a day after we started coconut oil because he was scheduled for these two clinical studies testing and they were in two different cities and he had a dramatic improvement in his score from the day before to the day after he took coconut oil and it was you know really fascinating and I thought well this is for real or did we just get lucky you know that he scored you know he had a better score but decided to keep it going and it was very obvious over the next four to five days for him he was what we would now call a dramatic responder he's somebody that I mean he became much more alert more talkative the animation came back in his face he said it was like a light switch came on in his head the day started coconut oil and he said that over and over and then we started eventually adding MCT oil to try to get his ketone levels higher and I was reluctant to give up coconut oil because it has many health benefits the lauric acid and it kills bacteria viruses other things that could possibly contribute to Alzheimer's we just didn't know and I didn't want to take a chance of stopping that so I started mixing it and he actually improved quite substantially over the first year he improved so much that he was able to work as a volunteer in the hospital where I worked and in the supply warehouse he helped deliver supplies he would put stickers on supplies and then he leveled off you know for another year after that and so we're at the two-year mark and he did get into a clinical trial he was on the placebo for the first twelve to fourteen months so he had a whole bunch of testing I mean he improved quite a bit on cognitive testing on functional testing during that year and then he did level off and then we think he was actually on the medication it was a crossover study and he was probably on it for five to seven months and he started declining after about two years and just some new things that we were seeing and he was having side effects that you know from what we learned later was that he was actually on the medication and I actually took him out of the study because they were very significant side effects and then it turned out that drug accelerated worsening of Alzheimer's yeah we found out a few months later terrible so this is the point where the ketone ester comes in that's as fast as I can tell that story by the way yeah no I don't wanna I don't want to rush the story cuz I think that it's pretty incredible that you saw this clinical I guess the data around exon all this food and you reverse-engineer the patent to realize that this was medium chain triglycerides I mean just just stepping back ma I mean obviously your passion and in your love for your your your husband I guess spark that but I'm curious anything else that sparked anything else you tried what zero do on specifically on ketones as an intervention versus you know there's a number of things that people say it could help you or could help someone else I MERS we were trying all different things for one thing we had already two years earlier started we swapped over from what I call the conventional diet or the convenience food diet because we were very much into easy foods packaged frozen foods eating fast food you know they don't teach you about nutrition a medical school so I didn't really know anything about that and I read a study about Alzheimer's and that the people who ate the most Mediterranean like diet lived for years longer on average than people that ate the least Mediterranean like diet and then I thought wow nutrition could have something to do with this you know so we actually switched over both of us you know to a Mediterranean whole food you know whole-grain diet in 2006 so about two years before we started you know before we started the coconut oil and another thing too was DHA there was about to be a study of DHA 900 milligrams a day very important omega-3 fat for the brain and I thought you know why would we be in a clinical trial when we can get this over the counter and risk that he would get placebo for an essential amino acyl fatty acid so I put him on 900 milligrams a day so he was probably for about two years we were doing all of that and I was keeping my eyes open you know there are other supplements you hear about phosphatidylserine there were you know over time even before a knee after the coconut oil there were a number of things we tried and the only other one that I ever saw any difference that I thought I could attribute to the supplement was d-ribose which is a very interesting it's a sugar that you make from glucose within cells you don't make it outside it's not made outside of cells that's made within cells from glucose and it's part of the ATP molecule and I thought okay well that makes sense to me and his he liked his flow of conversation improved very substantially after a couple days of taking that but that's the only other supplement I ever had you know tried for him that seemed to help I mean just also just stepping back into that era this is almost this is over ten years ago I think today keo keo genetic diet the term keto is is is essentially viral it's everywhere it's the the Google search trends are growing exponentially but 10 plus years ago nobody knew about it right and ketosis is probably a term for ketoacidosis where people would say this is a poisoned state of the physiology don't do that this is dangerous yeah I'm curious to rewind the clock here and get a sense of when you were putting your husband on a kid drink diet supplemental coconut oil which is you know saturated fat all this stuff did you you push back all reconsiderations you think that you were doing something wrong I'm curious to go through your analytical process as you decided to go on coconut oil MCT oil and then eventually try out this ketone ester I was aware a little bit of the ketogenic diet from medical school they mentioned it for Emma lepsy you know that it was a last resort for epilepsy but you know that it was unpalatable it was very hard to follow and you know that was really all I knew about it and I did have one patient while I was a resident that was on a keto diet for epilepsy this was in the 1970s and but other than that I hadn't heard you know really much about it other than like Atkins diet or something like that when when I first read that this is extracted from coconut oil and I'm thinking about going out to get coconut oil you know I thought well it's in health food stores but I always thought it was supposed to be the artery-clogging fat you know so but I thought you know on the other hand his brain is dying his brain is dying from Alzheimer's and what are the chances that starting coconut oil would would cause a heart attack before he would die from Alzheimer's so I mean that was my thinking at the time risk versus benefit which every doctor does with every medication they start they have to consider both and I thought in this case if ketones could help revive some of those cells in his brain and get him functioning better again or maybe keep him from getting worse it's worth trying you know so that's where I was at and I bought it and I started reading everything I could about coconut oil and I learned very quickly about the health benefits I've heard if it was in health food stores there must be some health benefit and there are there numerous health benefits and it's this whole thing about saturated fat is really completely blown out of proportion it's it's based on really flawed science and in I think all three of my books I have a chapter dedicated to that discussing the real studies not the pretend there were cherry-picked studies that they used to come up with this from the nineteen fifties sixties right the epidemiological studies that a lot of people have criticism on yeah so so nobody knew about ketones when I would talk to doctors about it their first reaction like you said diabetic ketoacidosis and there are many medical textbooks that just out-and-out say ketones are harmful you know what I've gone to Asia they say but our medical textbooks say ketones are harmful well if you're in the range of diabetic ketoacidosis you got there because you had no insulin very high blood sugar that's a very abnormal state and this is nor usually a type one diabetic it can be somebody with type 2 diabetes it's often when they become diabetic and they don't know it yet that this happens it can happen in other situations but very abnormal and the ketone levels become many times higher than what you could possibly get from coconut oil or MCT oil so you know we're talking point 5 millivolts versus 10 15 20 25 milli moles I mean vastly higher levels so you know fats breaking down very quickly the body is unable to buffer it you know and levels are that high but your body can buffer you know normal nutritional ketosis you know in the physiologic range yeah and I would say my analogy for why ketones are there is that it's sort of like the ambulance for your energy because in a type 1 diabetic there's no insulin production you cannot use sugar for energy so therefore the body vote is forced to use fat then produce ketones for energy because there's no insulin Dov backstop that ketone production then ketone rates escalate but really the purpose of ketones in that system is the ambulance it's trying to repair and fuel the cells and it just happens to be that there's no sort of a kickback loop so the ketones themselves are more like ambulance you're not blaming when there's an accident the ambulance obviously is gonna be there if you're not blaming the ambulance for causing the accident the ambulance is there to try to rescue the situation and I think in early science where people didn't understand the physiology the ambulance there the ketones there are I think we're blamed for not the full understanding of what's actually going on there I agree with you on that and some type 1 diabetics or even using ketogenic diet to control her blood sugar which seems ironic you know because diabetics who think they're the ones need to worry the most but there's doctor well he's uh and ruku Nick he's at University of South Florida he's given presentations on this and he's been able to amazingly control the fluctuations in his blood sugar and keep him really fairly close to the normal range with 75% insulin by going on a ketogenic diet that's where it's interesting where typically as you mentioned type 1 diabetics are deathly scared of having high ketone levels and it sounds counterintuitive - ok we'll put someone on key Genk diet but if you can manage it well then that might be interesting where you don't need to be just jammy insulin all the time anymore which is an interesting trait I diabetes is a sugar problem and if you don't eat sugar you don't have to it's not that big of a problem yeah so going back to Steve's Stephens story so you try coconut oil as he tried MCT oils and that I imagine wouldn't bring up his blood ketone levels to around 0.5 1.0 millimole that sort of range right yeah probably in that territory and he was getting a lot of it I mean you know the medical food was going to be 20 grams of MCT once a day and when we measured Steve's ketones his level peaked at 90 minutes and the ketones were gone at 3 hours and I thought well what is his brain do the other 21 hours so that's why I started measuring you know with coconut oil that level Peaks around 3 hours and it's lower but a lasts longer and so I thought if you mix the two together and give it 3 or 4 times a day he could have ketones available 24/7 and then just started pushing up how much we were giving him so he was getting a huge amount 9 10 11 tablespoons a day of coconut and MCT and then he stopped eating so much carbohydrate I mean he put away the fruit and he wasn't eating the bread in the pasta and the rice and so he I think effectively he was on a ketogenic diet his levels could have been higher but we just I don't think the device was out yes to measure them the other measurements we had were done at the NIH by dr. beech we mailed him samples and he measured his levels at that point well the things that strikes me and I think a lot of people that have used MCT oil or cooking oils wood wood you know one of the common mishaps is having too much and causing GI distress it sounds like obviously Steve built quite a bit of tolerance to have that much MCT oil but here's the here your perspective on done tolerance and how do you find a balance between having enough of the ketogenic fat to produce ketones versus upsetting someone's stomach that's been a very common problem you know with the the medical food since its come out they find about one in four people have trouble tolerating the 20 gram dose that they have and we were fortunate that Steve tolerated it was over two tablespoons of coconut oil I was trying to give him I kind of calculated how much coconut oil he would need to equal the dose of the medical food and I came up with 35 grams which is a little over two tablespoons and he tolerated that the first time but some people take one teaspoon and they have diarrhea yeah so we were fortunate because that would have been the end of it you know if he hadn't tolerated it and we found with the MCT in coconut we had to go up slowly if we did go up too fast he would get diarrhea you know and we'd have to back off for a while wait a couple more weeks and then inch it up even slower and you know over time we were able to get get the dose up you know quite high but you know some people struggle with that even a quarter teaspoon of MCT oil is enough for some people to send them into the bathroom for like a couple of hours it's incredible we've done a couple of pharmacokinetics studies of MCT OS in the office at HB MN and a couple I just remember a couple of our colleagues I think though might be one of the colleagues actually spent quite a bit of time in the toilet yeah after that experiment so I guess a caveat to some of the listeners who might be wanting to implement mary's protocol here that might be a consideration start slow with a lower dose and then ramp up as you build tolerance and eat it with food right in with food and it's not uncommon it's not that you were getting poison necessarily it's probably a sign of your stomach not being adapted that having such a high fat content all at once but something that can be built up in terms of tolerance yeah so how did you come across doctor Veatch NIH the ketone ester and the it curious to get the the story in how he came across the world of exogenous ketones so instead of having to eat icky genic pre-tax to have to produce ketones endogenously what is the story in terms of finding that you could consume these ketones exogenously dr. beach when Steve improved with a coconut oil probably within a few days I called him I found him on Wikipedia for some reason his phone number was right there which was amazing and he picked up the phone I called and I asked him I said do you think it is possible for someone to with Alzheimer's to improve from just taking coconut oil you know and he was like oh no no he said the levels would be much too low you need much much higher levels and and that he mentioned that the inventor of the ax ona product had talked to him like several years earlier and asked him the same question about MCT oil and he told him no it's not gonna work the levels aren't high enough and but I already knew that it did work at that point for Steve it's it seemed to be working you know it was either the biggest coincidence in the world or you know it was doing something for him and so I thought okay so I kept reading and reading reading he sent me I think he sent me a couple of his articles about the ketone ester he mentioned the ketone ester he said you wouldn't need much higher levels and you know that he had been working on this ketone ester since the 1990s he told me about some of the studies they had done and you know that he lacked funding you know from the NIH to mass-produce it and do clinical trials for Alzheimer's and they were mainly looking at it for Department of Defense for the troops yep to see if it could help improve their physical and mental endurance and so you know if we left it at that that first conversation and then when Steve the day before the coconut oil when he did not qualify for the study the doctor him draw clock which is a test for Alzheimer's and he drew this a few random circles not a big circle even a few little random circles and a few numbers and she said it's very disorganized it looks like he's on the verge of severe Alzheimer's and that was scary that really was my impetus to say we're gonna pick up coconut oil and see if we can do something you know anything to help them and so two weeks later he drew another clock and this time full circle all the numbers were there it had numerous hands of a clock like dozens of hands the clock and it was so much more organized you know it was messy but it was just amazingly better and I faxed the clocks I talked call dr. beech and I faxed the clocks to him and then he called me back and he says well this is unexpected he said those were his words this is unexpected I really didn't think he didn't really think the levels could be high enough to help somebody so he was fascinated and he sent me more papers and within the next 24 hours I got calls from the three you know of the researchers physicians and researchers who were interested in ketones and they had written hypothesis papers about it and this was dr. theodore van italy dr. sami hashem and dr. george cahill jr who had discovered that during starvation your brain is fuelled off of ketones two-thirds of the fuel supply to the brain is from ketones so they all called me within 24 hours and I didn't know who they were or how important they were but it was to me it was just amazing I took notes you know I talked to them I was trying to learn everything I could and how do they find heard contact information it was a dr. beach gave it to him my phone number and told him to call me and they all did yeah George Cahill's a seminal paper starvation of man is an interesting paper I think I think just where the folks are listening one of the key results was starving I believe thela the theology students for 40 days that was the second study the first was a heavy an obese nurse she was her first volunteer and she it was for 41 days yeah which I don't know if he could past ethics approval - in the modern day the stars hundred forty plus days but that was some of the interesting research to show that yes you could fuel the brain with ketones and ketones would actually be the predominant fuel for the brain in the kind of starvation State which is obviously all kind of the underpinning framework that yes you can fuel the brain with ketones and glucose or sugars not a required substrate for brain function so I I stayed in touch and I still you know talked to doctor Veatch once or twice a month on average I would say now and you know so then my big thing was I got a I have to get this message out there are 35 million people in the world dealing with Alzheimer's and not to mention also Parkinson's and ALS and MS and you know diabetes you know all of these people could potentially benefit from this ketone Estero the doctor of each had you know and maybe in be you know before that you know in the meantime use coconut and MCT oil so I wrote an article that I started writing to politicians and media people really got no response I was trying to tell them you know about Steve's case study but this is about a medical food that's going to come out in a year but it's available on the shelves coconut and MCT but there's this ketone ester dr. beech is working on he debt he needs funding for it so that this needs to get studied urgently you know and I Alzheimer's Association you know I even I went to their conference I was I had written up a case study it's available on my website from 2008 little case report about Steve that I was gonna present and try to get the researchers interested there and studying ketones there were 5,000 people from all over the world attending this conference and first the Alzheimer's Association approved me to have a table and then they didn't they pulled the approval about three days before the conference and so I met you know I went to Chicago anyway I attended the conference I snuck as many two people as I could of the article but they were not gonna stop you from spray that's crazy and I had chats with them at various times you know this is just a food you know the MCT in coconut and there's this ketone s or why aren't you funding this and they said well you know why aren't you telling people about it it's just the food and they're like well it needs clinical trials you know before we can tell people about it I said but you're the guys that fund the clinical trials one lets you do a clinical trial and they just you know weren't doing it but you know I think they had gotten proposals you know probably from dr. beech and you know to try it but they just hadn't done it and so that was very frustrating and you know I ended up doing a grassroots approach then yes I presume at the time though this is late 2000s early 2000 so 2008 yeah this is still 2008 yeah two months after Steve and so the amyloid tau plaque thesis was so predominant was predominance and as you fast-forward now into 2019 all these neurological programs attacking that pathway have failed and a lot of the big drug companies have pulled out of the neurological programs because the targets were amyloid plaque Towe have not worked so so I guess this is in the heyday of when this it was I guess a relatively new hypothesis this is where all the funding was going to this is where all the academics are focused on yes okay and you should have seen the size of their exhibits at that conference XO 'no actually had an exhibit there and i went to them and i would say so what is what is in your product and they would say oh it's a powder and i'm like no i mean what is the act of you know it was like pulling teeth to - for them to say it was MCT oil you know which was interesting and i thought you know if they're not going to tell doctors and researchers what's in their product nobody's going to understand it much less use it you know so I just felt like they were gonna have a tough time and they I think they did they might still be struggling you know out there with it but you know so I you know doctor of each and I were just constantly talking at that point and one of the things we decided to do was to go visit my representative Steve and I visited her locally you know our representative from Congress and to talk about this how you know this needed urgent attention you know for funding you know and so he and I and dr. George Cahill we went together to Congress and visited my representative Ginny Brown wait at the time we were standing in the hall outside of where they had just voted on something it was I mean one of the most amazing days of my life and you know it didn't get anywhere you know she was very interested she actually had somebody in her office that started doing that approached a friend of one of the people that worked in her office who started talking again after not talking for almost a year well it was incredible and so then you know I said to dr. beech do you think I should write a book about this you know maybe if I write a book I can get awareness out about ketones about the ketone ester or maybe that we'll get funding and he said yes and it took me about 16 months to get to write it you know I'm working full-time I'm taking care of my husband with Alzheimer's I would get up really early in the morning and spend two or three hours writing before he woke up and before I had to go to work and I had there were so many papers I mean it was surprising really at the time how much ketone research had taken place but there was a lot of other you know stuff I had to research you know like if I would get a an article from dr. beech I would read and get the articles and read the articles you know related to that that were important and so you know the middle my first book was called Alzheimer's disease what if there was a cure the story of ketones it took forever to get published it took about a year and a half after I wrote it to actually come out she was very frustrating but it was long it was 500 pages I think and you know I just wanted to really get it right - and it actually did pretty well it did pretty well and the 700 club which they invited us to do you know a story so they came to our house they filmed it it was a little five-minute story about ketones they talked to dr. beech and they had an amazing little thing about how ketones work a little video showing how ketones are taken up in the brain and that went viral that you know they said they had five million views that year of pretty quickly most of them you know after they aired that on their show and so that got the message out and people are still using it so people that sell the ketone salts constantly use that video to to the people that haven't heard of ketone salts and what they can do so you know that you know really I was just obsessed with being a messenger and you know writing about it was part of that so you know I probably had part of the book written by the time Steve started the ketone ester and it was a secret it was the secret at that point it was dr. beech you know considered a pilot study of one person and he could only make enough for one person in his lab it wasn't available to anybody else at that point yeah I know it's you know one of beaches lab research scientists hand-making this yes drop by drop by drop yep yeah few milliliters at a time he worked on it every day and so what happened was you know Steve started having those side effects that we I you know we're most likely due to that clinical trial medication that failed you know and accelerated the disease and so he started doing some strange things that he hadn't done before even though in other ways he was doing pretty well he put his clothes on backwards and one day we were standing in the mirror this was horrible and he said you know he said I can see that's you and he said this is me from the neck down but from the neck up it's not me as somebody else and I thought what that is strange and that was the beginning of him being confused by Mears he would see his father when he'd look in the mirror we actually had him grow a beard because then he didn't look like his father it was and it worked so you didn't recognize his own face basically they didn't recognize his own face and that's a common problem with Alzheimer's is so strange and he started wandering from home his brothers lived about seven or miles away but he he'd start wandering saying he was looking for his brothers and you know he he kind of deteriorated in his ability to function and I had to start talking him through things like shaving and taking a shower and I mean when you talk somebody through with Alzheimer's so you have to say okay now okay your hair wet you're standing in the shower okay now put some shampoo now rub it around okay now rinse it and step by step by step the whole shower and same thing with shaving and you know it was just it was startling that that was happening and so doctor of each and I talked about it and he said well you know we finished toxicity studies it went well you know people didn't have adverse effects it was approved you know the FDA you know I think recognized it maybe for use for five days or something at that point right the earliest grass status yeah well what year was this April of 2010 and so dr. Veatch said that you know he had taken himself to testing to make sure it wouldn't kill some he's he's such an interesting man I love dr. beech he's my hero he really is my hero and he said I'm gonna send you this and he said I've been wanting to send it to Steve but I wanted to wait till the toxicity studies were done and it's the time now he said you you can't imagine how amazing that was to us to be the first people you know somebody with Alzheimer's to get to try this ketone Esther yeah I've been writing about it I've been telling every people I've been trying to get funding for studies and and here we were in the first people to get to try it and it was just incredible and you know so it arrived on our doorstep you know in a Ocean Spray cranberry bottle sealed up that taught Todd King had put it in that's how we always got it and we had the raw material basically we had the pure raw material to work with which tasted horrible it tasted like you know jet fuel it might even taste worse than jet fuel I don't know it wasn't it wasn't a fad and Todd said you know they had tried various things you know there and there lay out you know different flavorings and things like that so he suggested that I diluted it one two for you know three parts water to one part ester and then just see what I could do with it you know to try to flavor it somehow you know we tried so many different things it's come a long way since those early days of the raw internestor I mean I think it's funny that that people college or compared to jet fuel because my question is how they try to drink Jeff feel how they compare that yeah well coconut oil is actually like they can use it ten percent of the fuel is coconut oil did you know that hey listeners if you're enjoying this episode thus far please consider writing a review on our iTunes page it really does help increase the visibility of our podcast that's really the best way to support our work in appreciation for your review we'll hook you up with $15 of hvm n store credit we also love it when we see guys share our episodes that you've enjoyed on your Twitter Instagram or Facebook and we often reshare those posts just tag us at our handle at hvm n now back to the show I would describe the raw raw ketone ester as a weird blend of a liquor shot with some astringent C and some smell like acetone or nail polish remover combined those kind of together and the worst tasting thing you could possibly imagine you know I had like different family members they would try just a tiny sip of it and they said I will never take that again because the aftertaste to it would leave an aftertaste in your mouth I mean I tried to full doses of it a couple times you know because I wanted to see what Steve might feel like you know maybe while he was taking it and I was like oh my gosh this is really bad I'm just it's amazing that he can drink this and and he did shudder every time he took it he shuddered but he such a willing participant he knew he had Alzheimer's he knew what he had lost you know what he could do before and could no longer do he was always aware of it and he was a willing participant in all this he couldn't wait to try it yeah and so he videotaped him for two hours before and when he took it and then after and I watch it every now and then to remind me because it was such an amazing day and he was euphoric it was just felt great and he hadn't been able to say or write out the alphabet you know for like a few months at least you know before that and he took he'd spent 20 minutes which in and of itself was amazing for somebody with Alzheimer's but he tried and tried and tried for like 20 minutes you get like partway through the alphabet finally he got all the way through the alphabet saying it and writing it out he had tried the numerous times to write it out he finally wrote it out and he was so happy he was so happy and he talked about his abysmal penmanship he pulled out of his hat he said you know he called his his first-grade teacher by her name sister Anthony and he called her a name you wouldn't you know want to repeat her has a visible penmanship um and I had never heard him even mention her before so you know how he pulled her out of the hat you know was amazing to me but you know it was incredible and then the next day he could take a shower automatically he didn't need step-by-step instruction he picked his clothes out he put them on right and you know just very quickly 24 hours there were noticeable old differences and then and this was off of 125 gram bolus one third twenty well Todd suggested and dr. beech suggests that we give him 20 grams three times a day okay so it was a pretty hefty amount you know and then we upped it I think a couple days later just a little bit to 25 grams three times a day somewhere around there and he you know basically continue to improve over six weeks where he got back to where he was before we started the kita before he started declining again he stopped wandering he you know was able to do things out in the yard again and you know just functionally you know he could read a menu and choose something off a menu which he hadn't been able to do for a while and and he just said he felt good and he felt like he could do things and you know that was one of his things with Alzheimer's I can't do this anymore you know and now I can do things again you know so that was what changed so his lights came back on he was lucid yes so you felt like you had your husband back for that time and that was another 20 months that he was stable you know that he improved and then he leveled off and he was stable again for another 20 months you know which was really quite amazing so it you know it he we had at various times you know he ended up taking it my husband many people might not know this but he did pass away from Alzheimer's in 2016 so this was about six years after he started the ketone ester he started having seizures in 2013 and he fell the very first time he fell back and hit his head and he stopped breathing he turned blue for about 20 minutes it was a 20 minute seizure I had just left home I was at the hospital his caregiver called me and said she had called 980 for them and that he was blue and I got home he was still blue when I got home it was horrible and he was unconscious you know when I got home and they said he had another seizure on the way to the hospital and you know Alzheimer's that happens in Alzheimer's and he happened to be standing and he had a hard surface with his head and he never was the same after that so he was dependent after that we had to feed him and he was in a wheelchair much of the time and we kept giving him the ketone ester and we did you know we had times when we couldn't get it you know the supply would run out you know they would run out of money to bake it literally and so we had a couple months he didn't get it and saw a pretty big decline where he really couldn't lift his head up and then dr. beats you know when he was able to get it to us again you know within a matter of a day or two he was lifting his head up again you know which was kind of incredible so even in the late stages people ask me that all the time could it help somebody in the late stages and and I have numerous stories about that where people have improved you know with coconut MCT oil and now with these exogenous you know ketones you know people that weren't talking that are talking and you know smiling again making eye contact things like that so it's really dramatic you know what this could potentially do for people with Alzheimer's it's incredible story and I think we've seen some of our customers send in videos and I think obviously very very late stages it's not a magical liquid that will bring someone from very very late sites Alzheimer's back to normal right I think there's the caveat expectations but some of the videos have you know people the caretakers will see that you know they can lift their heads up straight you know they can actually look people in the eye again which for very very late stage stage dementia is is definitely an improvement but at a certain point there's you know damage chronic damage both of over time that you're not reversing all of that but you can rescue some of that brain energy deficit I think during that early early phase it would have cost thousands of dollars per dose of ketone esters so yeah I think the cost was $600 a leader or a kilo that they were making making it so that's asea kilo is 2 pounds about roughly yeah and you would need that much at the amount that dr. beech felt people needed you would need that every 10 days you know so it was expensive the raw material but you know one question I have and you might be able to tell me this you know I we didn't know if we were giving Steve if he needed as much as he was taking you know we did ketone levels by then when there was a ketone meter we could use to check us ketone levels so we experimented with dosing anywhere from you know 20 25 grams up to 50 grams and 50 grams got his ketone levels up to 7 million moles yeah at an hour you know somewhere around 45 minutes or an hour and so we ended up settling on usually 25 grams a dose and you know after his seizures dr. Veatch said let's push it and we actually had him up to i think 150 grams a day you know for a little while to see if it would make a difference you know he did he did I mean he did get to the point where he was up walking about again you know it just most of the time he had to be on a wheelchair he just needed a lot more help after that he did improve you know after that seizure but you know we I I hear of people today who are taking 5 or 10 grams even once a day that are reporting improvements and you know and their memory may be functioning somewhat better so I just wonder what you've heard about that so I think in terms of dosing there's the body weight component obviously the bigger mass someone has the more ketone ester is needed to elevate the blood levels to a level that a substantial portion of your brain energy deficit is potentially recovered in a in a in a brain with some sort of glucose uptake dysfunction so we've seen folks report in with around 5 or 10 grams of ketone ester getting their blood ketone levels to around 1 1 and a half millimole ketone yeah that's what I've heard to which is consistent to your experience with MCT oil and coconut oil if you've seen benefit from having a mild elevation of ketone levels to 0.5 or 1.0 then a micro dose if you will of ketone SS or it could get you that equivalent level so I think this is where it's sort of cutting-edge research where we're working with folks like Steven Kooning up in Canada looking at well what is exactly the level of dose that you'd need is it more of a millimole you know what is the minimum millimole of ketones in the blood that would start use uh that would enable the brain to use a substantial portion of the brain these ketones as a fuel and I think that's where science is yet to be done but we're excited to be put a contributor part of that yeah I think he's gonna do a stepwise study you know start maybe at 10 grams you know two or three times a day and increase from there I've gotten a chat with him a bit about that but the amazing thing to me is the Alzheimer's Association didn't want to have anything to do with this idea in 2008 and then about two years ago they actually came around to funding a study of MCT oil with dire Cunnane yeah for a mild cognitive impairment to see if it could prevent advancement to Alzheimer's and that studies they're halfway through and it's about to be published and the results actually look good you know with about 30 grams a day which is two tablespoons of MCT oil and they felt that probably 45 grams would be even better but now the Alzheimer's Association is going to fund the study with a ketone ester the ketone ester which you know here we are see 11 years after I try to get attention for this but they're gonna fund a study and you know he has an opportunity you know like you say he can start people on a lower dose and I do think you know they may be able to determine you know maybe per kilo you know how much well you know at what dose will a person achieve the Mack the minimum benefits and the maximum benefit you know above which more ketone won't help you know possibly so I think it's just gonna be an amazing study I'm sure it'll take a year and a half two years he seems to do a great job of recruiting people quickly to his studies he gets the studies done you know you know quite well and just keeps at it and you know with what he learns from it is just incredible they're going to do cognitive testing and they do ketone and glucose PET scans you know they can see how much ketone has taken up by the brain which is amazing he's one of the first folks that really has a methadone yeah is it vindicating for you to see the academic role turn around to what you'd proposed and realize yeah I'm plus years ago I mean it must feel it must feel like rewarding I mean it's walk me through how you the feeling and in what some of the title shifts that see that that made this change happen well who needs work I think you know it's proof of concept when you can show you take MCT oil and it does increase ketone uptake in the brain and his other landmark study you know I feel is when he was able to show that ketone uptake us normal and the Alzheimer brain it's you know that the very same areas that have decreased glucose uptake take up ketones normally and you know ketones don't need insulin they go in by a different pathway the apparatus is still there in Alzheimer's you know so you know this is a proof of concept that dr. Vitas idea that it could help Alzheimer's this is proof that yes it there's every reason to believe that it can and then now he's done studies showing that they do have cognitive improvement and this is with lower levels you know 0.5 millimoles you know from MCT oil so now he has the opportunity to look what the ketone ester so you know when I to me you know when I first heard about dr. Cunnane and what he was doing and it was before he published the study about Alzheimer's you know the ketone uptake being normal I was following him in contact with him and telling people about him everywhere you know trying to get his message out too you know because I felt it was really important and I would say you know so that that was really a landmark thing dr. beech published a paper about as a transgenic model mouse model of Alzheimer's and so this is a mouse that makes amyloid plaque tangles and has cognitive that's right they studied and you know they used the ketone ester and they found compared to the controls that they did have less plaque in the brain I believe also less tangle in the brain and they had less anxiety and they did have some cognitive benefit from it in the mouse study you know I would also call it yours you'd the paper you wrote and you co-authored with Richard Veatch uh that I think was very exciting for me as a reader and a follower of the space because this was but this isn't and this is a human right you could say yeah we are not mice right this was the first person yeah there's a lot of mouse studies that have shown potential for a new a number of diseases don't that don't pan out in humans I was excited in to see that actual very very strong results from from from your work right and I got to do part you know part 1 and part 2 the medium chain triglyceride response and then the ketone ester response how it really brought him back around again to be able to get higher levels of ketones I thought that was you know an important part of that and yeah for me to have my name his first author on a paper with dr. of each and and dr. V on Italy oh my gosh that was just so amazing you know incredible dr. Vanderley recently said we should write another paper I'm like okay I'm ready so it's just been an extraordinary experience I never you know imagined and you know I'm getting I mean I started talking in health food stores locally and a podcast here there I mean after my book came out and after it got on 700 club you know so it took a while you know for that information to kind of get out there but now I get to travel everywhere you know there's interests all around the world you know Alzheimer's is an epidemic it's been increasing everywhere for example Singapore a beautiful place clean modern beautiful place and they have had a it's a 300% increase in early onset Alzheimer's in the last five years 300% in five years and so they are worried about this and so you know when somebody hears about you know this possibility that ketones could provide fuel and could help I will get an invitation to come and speak you know and I have an opportunity to get this message out in a new place you know a new country to people that may not have heard about this before and now that's very gratifying to me and it's just been incredible so we've talked around the mechanism a little bit there might just be helpful for our audience to just make that very very explicit so yeah obviously we've seen in a number of case study you know you know this is the case we of Steve and all the supporting work that ketones can rescue brain function in Alzheimer's patients so why is that what is the mechanism of action here well the immediate action is fuel that it provides an alternative fuel to the brain to glucose and the brain instantaneously can switch from using glucose to ketones the apparatus is there they've looked as early as the 12-week fetus you know the enzymes everything is in place to be able to use ketones and it's still there in people with Alzheimer's and I think the immediate response we saw was Steve was probably probably related to fuel but he continued to improve steadily and very it's much over a year and so another thing that has been learned since then is that it's an anti-inflammatory ketones are anti-inflammatory dr. Veatch said that you know but there's much more proof they've been able to identify where you know how it affects the inflammasome right and our lp3 enzyme is ohm right and it increases the scavengers of free radicals it suppresses the production of free radicals you know so death several different anti-inflammatory mechanisms and diseases like Alzheimer's and virtually all of the neurodegenerative diseases autism diabetes arthritis lung disease I mean so many diseases have as a feature inflammation like an Alzheimer's they have found recently you can have a bunch of plaque in your brain but you don't have Alzheimer's unless you also have inflammation in the brain which is interesting so I think that the anti-inflammatory factor you know very likely played a role you know also for Steve in the the gradual improvement that we saw over time yeah coconut oil has other factors lauric acid half of coconut oils lauric acid and it's antimicrobial it kills numerous viruses bacteria fungus so this is c10 lauric acid c12 right and c10 is also antimicrobial not just just not quite as much as c12 and there are hundreds of papers looking at various microorganisms more than a hundred about herpes simplex virus that causes fever blisters on the mouth and you know people they've found these organisms in the plaques in the brain and various studies you know where they've infected animals with herpes simplex and they develop plaques and tangles and cognitive deficits you know all kinds of studies and also sort of like ketones a story about ketones all of that's been suppressed I you know went to the last Alzheimer's Association conference six day conference not a single session about infections and Alzheimer's they talked a lot about the microbiome that's a new thing and how you know the gut microbiome affects the brain although they're not even looking they're looking at the bacteria in the gut but they're not looking and the changes in the brain you know there are microorganisms in our brain as we get older right you know and so lauric acid you know may have helped suppress an infection in his brain Steve he had an infection around as high with herpes simplex when he was 29 and he never felt the same after that and I thought I always felt like maybe that was a trigger you know why he got Alzheimer's so early and somebody that was so young and healthy and physically active and you know a novel reader and on a computer all day you know it didn't make sense to me that you know what triggers that an infection is a very likely possibility so does your experience with Alzheimer's suggests a different understanding of the ideology of Alzheimer's I mean I think through a lot of my conversations I guess the standard the status quo definition of Alzheimer's is some sort of amyloid or towel caused phenomenon but I think within the conversations around the low-carb ketogenic space is this a glucose dysfunction up take this function problem with with the with neurons with brain so this is more of the type 3 diabetes explanation of why Alzheimer's happens but that seems to be just a subset of possible forms of Alzheimer's would you say that Alzheimer's is more of an umbrella term for multiple multiple triggers yes of dementia or cognitive dysfunction versus one unified disease curious to unpack that story a little bit here dr. beech and I talked about this forever but even at the very beginning we you know we talked a lot about this you know that the plaque may be a downstream effect you know the metabolic changes the problem with glucose uptake starts 1020 years before a person even developed symptoms and they have done PET scans well MRIs of people in their mid-twenties who are at risk because of their family history for Alzheimer's and already they have decreased glucose uptake in the brain at that point so it's a very early phenomenon these metabolic changes and you know the plaque seems to come later it comes much later you know that now they can do amyloid scans to look for plaque and they can do Towel scans to look for tau they don't see Alzheimer's even with a large amount of plaque in the brain until tau appears and then it goes very quickly after that tau is it's a protein that it's the structure inside the axons and dendrites that connect neurons it's like the skeleton of the neurons and you this this tau protein seems to be attacked in Alzheimer's and it wads up and inside of them the the nucleus of the neuron it's really but you don't have Alzheimer's until the towel appears they learned this by in the last two or three years and you know the inflammation is another important component so when they look at these animal aide plaques I mean people have talked for years about heavy metals possibly causing it you know like mercury lead cadmium aluminum you may have heard of that and then infections and when they analyze these plaques they have these bacteria viruses they have heavy metals in it they have things like calcium carbonate you know which is in like Tom's you know calcium supplements that that so many people take and they have also learned that amyloid plaque is an antimicrobial substance it seems to be secreted in response to a microorganism in the brain and they have found heavy metals in these plaques so it seems like it's a part of the primitive immune system so it seems like there's some trigger that the plaque is responding to you know and not the other way around I'm glad that you brought that up I think that's again potentially I think this is early I don't want to over speculate here but similar to how ketones are demonized early do is amyloid more of an ambulance situation where it is write a response at the scene of the crime right it's a response to some of these infection and that's why all these drugs these failed drugs they've been trying to target amyloid have failed yeah they've removed and they remove amyloid from the brain the one Steve took was an oral medication that was supposed to help prevent further accumulation of plaque and possibly dissolve it and they've had they there was just another antibody trial it was a vaccine that they could see that it removed all the plaque from the brain and there was no cognitive improvement whatsoever yeah by removing the plaque so it appears that and now all the big companies Pfizer I think Merck and Lilly have all gotten out of the Alzheimer drug business they've spent millions of millions of dollars you know going towards this dead end and they're they're now out of the business so they are giving up you know basically and so they need to look another way and you know the last few years the Alzheimer's Association has started to stress prevention yeah you know they've been trying to fix it after the fact by attacking plaque and getting rid of plaque it hasn't worked and so what they need to do really is prevention and you know so that's where the ketogenic strategy's come in you know if you can keep those neurons functioning by providing fuel you know that the neurons are there I mean like like dr. Cunnane one of the big questions was you know when you look at an MRI of somebody that has Alzheimer's and a PET scan of somebody there's these big areas of you know where there appears to be no brain tissue there's like atrophy or shrinkage of the brain and also these areas of poor glucose uptake and they thought the areas of poor glucose uptake were there because the neurons were dead that they simply just weren't there to take up the glucose anymore but he said you know the fact that the neurons can take up ketones they are there they're like cars that are parked that don't have fuel they just need fuel in the tank and then you know they can function and no doubt you know some of them you know many of them have died you know but we have trillions of neurons you know so we have a big backup system in our brain and you know it is possible even to grow more neurons you know doctors used to think that you got what you got when you were a child and that those you kept those same neurons forever and now they're learning that it is possible to grow new neurons like in the hippocampus you know where memory starts and you know it's just you know very intriguing that the neurons really are there they're just the brain has shrunk yeah so if we follow the direction that okay there's some sort of glucose I'll take this function do we have understanding whether this is an insulin resistance of neurons or is it happening within the cell for example pyruvate dehydrogenase is somehow being inhibited do we have there there are several factors oh maybe we have to open up a little bit what are the contributing factors that's preventing glucose from fueling these cells and why our ketones able to shortcut or run in a parallel process and to fill in this brain and then when we and I think it would be worth it the defined for our listeners here that when we define fuel we define it as a substrate for the Krebs cycle right to make ATP yes so this is every sound inspiration this is the yeah this is in the mitochondria this is the power the power plan of the evolved life and you can either fuel the krebs cycle with well you can fuel it for the number of substrates but the two that were primarily talking about right now glucose which turns into pyruvate or ketones beta-hydroxybutyrate into acetyl co a and they feed into the krebs cycle right one easy way to think of ATP is you know when you flex your muscle every single muscle fiber needs ATP to do that yeah and to relax it again every single muscle fiber needs more ATP so you're constantly needing to make ATP for virtually every cell in your body and so there's this Krebs cycle that is a biochemical pathway that results in production of ATP but it has to be fueled so it's fueled you know by glucose ketones fatty acids can fuel it but they don't cross very well into the brain so they're not a good source of fuel for the brain so basically for the brain it's you know that the main sources would be glucose or ketones so the other thing so so several things happen in Alzheimer's that they've been able to document one is insulin deficiency and insulin resistance in the brain so another is the insulin receptors you know there's one group that has been able to show that the insulin receptors which should be on the surface of the cell aren't there like there's some kind of amorphous substance that seems to be trapping or preventing the insulin receptors from getting to the surface of the cell which is really interesting so that could explain some of this problem with insulin resistance that the insulin receptor receptors aren't where they're supposed to be you know in the cell pyruvate dehydrogenase deficiency so you know this is one of the enzymes involved in breaking down glucose so that it can enter the krebs cycle that's deficient and then there are these gluten transporters glucose transporters called glute one and glue three that are deficient in the old timer brain and glute one helps get glucose into the brain help cross the blood-brain barrier and glue three helps get glucose into neurons so those are deficient you know so to me it's like there's a conspiracy of getting glucose into the brain you know but ketones don't need any of that to get into the Krebs cycle to produce ATP right the transfers are completely different if glucose transporters they go through what's called a mono carboxylic transporter which is in completely separate from glucose uptake right so do we have any speculation on what is causing down regulation of glue transporters pdh pyruvate dehydrogenase insulin receptors are done regulated and and i think that's an interesting observation in the broader context of increased rates of metabolic syndrome diabetes all of these things yeah can we speak towards the broader I don't know if I was a conspiracy but the broader context of why all these things are accelerating I don't know for sure the answer to that but a very large suspicion of mine is that has something to do with what we're eating the last 50 or 60 years obesity has been on the rise diabetes has been escalating if you get to be 75 in the US three-quarters of the people either have diabetes or prediabetes it's astounding it's happening in very young children and you know we've been on this very high carb diet a huge amount of sugar we're eating there's some statistics showing back in like 1820s people were eating on average six pounds a year of added sugar which sounds like a lot I mean six pounds a year cheese well now it's over 130 pounds a year of added sugar in the US it's incredible and trans fats you know they're now in the process of being phased out in the u.s. they've been banned basically by the FDA in 2002 they started requiring food manufacturers to label whether there are trans fats in the food so trans fats are these fats that are produced from subjecting oils to very high heat and pressure and the structure it actually saturates the fat but it also twists you know I think of it as twisting the molecule it's it's an abnormal shape and yet these become part of cell membranes they don't fit normally into the nice fluid cell membrane they make the cell membranes stiffer they shorten the life of the cells you know so trans fats you know have been out there you know most of us alive today we're eating a whole lot of trans fat you know most of our life if we were eating out eating a fast food larger than ever all that stuff margarine Crisco I mean Crisco was used constantly you know I have a lipid researcher friend at University of Maryland and she said they used to measure you know in like a medium serving of McDonald's fries before 2002 35 grams of trans fats well massive amount of trans fat you know and these are not normal fats or you know so I think that could have played a role I think you know it could be you know the sugar you know I wonder what feeds microorganisms you know why you know why do people get infections in their brain you know is this a fuel we know it's a fuel for Candida that's one of the culprits that has been looked at I need to research more you know they're different microorganisms on what fuels they use you know the inflammation in the brain you know sugar just really high chronic high levels of sugar produces what are called advanced glycation end-products and they're sticky substances this happens when you know fat sugar combines with either fat or protein and diabetics are very prone to getting damaged to many different tissues from having chronically high levels of glucose so the inflammation in the brain as well you know can be attributed to that and I think it could be a set up you know for and action you know if you have inflammation in any tissue you know there's a good chance you know a reasonable chance that a microorganism will find that and try to grow on it you know produce an infection so I I do think you know the biggest culprits are probably sugar very possibly trans fats and you know just getting away from eating at natural whole food you know diets which our ancestors ate hey they didn't have all these convenience foods that we have today so many chemicals in our foods they've been genetically modified we don't know how that factors in yet if it's important or not it very possibly is the micronutrients you know we're eating like we say you take a vitamin supplement a lot of those supplements are synthetic vitamins they're not the naturally occurring forms of the vitamins so are we getting when we do that instead of eating you know vegetables you know are we doing the right thing there's you know white flour it's it's really pure sugar you know almost pure sugar and they've had to fortify it with B vitamins the the vitamin that they're using is called thiamine mononitrate and it's not a naturally occurring form of thiamine you know the nitrate part of it it doesn't it's partly fat soluble which B vitamins usually aren't so it could be stored in fat it could be accumulated in fat and when you think about the diet of the average American probably almost every meal and snack they have white flour you know almost every single meal and snack you know many many people in the u.s. you know so where does this vitamin go if it's fat soluble does it accumulate in the brain I mean I have so many questions I think about the stuff you know I I can't sleep some nights because I think that's why I think you're just unpacking it I think this is complicated it is complicated I think modern processed foods have saved a lot of lives in the sense that famine used to be one of the biggest killers and I and for better for worse we've resolved that problem but now have we unpacked another can of worms which is that all these processed foods which prevented people from starving to death which is a good thing but but now are causing these chronic diseases that are now coming home to roost I think that's where I think folks like yourself folks like ourselves folks in the bar community are trying to change the paradigm now and we're like I don't think we blame processed foods for taking us from starvation famine prone species in society being able to feed everybody which i think which is good but that's just step one now that everyone is fed the problem is being overly fed and fed with non optimal nutrition that is causing these chronic diseases can we now take the next step to evolve our food supply in our education there to a place that that doesn't let us starve to death but also does not give us chronic diseases potentially and hopefully that is you know what we all work on together here so you've written the first book which kicked off this you know this this interest into key inject diets ketones into Alzheimer's I know you just recently published the complete book of ketones which is over our shoulders yeah I've had a chance to read through some of the key areas there I think is one of the most comprehensive historical overviews on the history of the space here and I think that a lot of this knowledge is hidden in different podcasts or conversations like this in the scientific circles but it's very cool to see all this I would say oral tradition this knowledge of ketone and ketone research in one specific area so I know obviously you're out getting the awareness out with the complete book of ketones but what else is on your docket what other projects do you have in the works I have three or four more books I would like to write one thing you know I think just you know continuing to get the message out there you know it's great to be able to do a podcast like this because it's that many more people you know that this information gets out to but you know diabetes is such a big big area it's such a big problem and people can reverse diabetes type 2 can be reversed with a ketogenic diet people can get off insulin in a matter of days and off medications in a matter of two or three weeks with a ketogenic diet dr. Eric Westman I've heard him speak several times but at the last conference he he's had over 4,000 patients now type 2 diabetics that he's gotten into remission they've lost 76 thousand pounds with a keto diet and and now you know you know the ketone supplements having you know exhaustion is ketones to be able to take you know to boost ketone levels even higher you know than what you know we the average person is capable of doing with a ketogenic diet is really incredible you know so I you know I've been a messenger for ketones since 2008 including the ketone ester and to me it's just extraordinary that it's finally here it's available you know people can actually buy it and they can try it and they're actually going to be a clinical trial starting soon for Alzheimer's you know for this ketone ester I just you know look forward to following you know seek watching all of that unfold and you know I encourage people you know who are thinking about using it for Alzheimer's or any other medical condition to get their doctor involved there's some things about the ketone ester for example when you know whenever we checked Steve's ketone level we also checked his blood sugar level and consistently we saw his blood sugar level go down and I do that same thing with myself and I see my blood sugar go down and so people who are diabetic taking insulin need to know that they need to monitor their blood sugar closely so that they don't bottom out and get hypoglycemic you know while they're if they're doing something like this you know there can be changes in electrolytes and things like that so I you know one of the big things I want to do is go out and educate doctors about this doctors still I'd say 98% of them still don't know a thing about this you know they don't know about much about ketogenic diet you know like I said even today they're not really taught much about nutrition in school much less about the ketogenic diet benefits hopefully that will happen soon I think talking a lot of doctor friends they've gotten four hours of nutrition lecture over the course of medical school exactly I had it one afternoon one afternoon for about three hours was the extent of my nutrition training which is why we were eating the convenience food diet for so many years yeah but you know just trying to you know get out there and educate doctors about food and how to use exogenously tones with their patients you know what they need to monitor you know what they need to watch for how much to use you know what Contiki tones do what are the possible indications or applications of it you know and they're gonna want clinical trials you know doctors like to see clinical trials been rightly so I think let's if we believe in the science then it should have the results so I have absolutely no problems you know helping make that happen right if we if we think this works then it should actually work in an RCT it should the other thing too it is a food substance you know it's it's considered a food it's not a drug it's not a harmful toxic drug beta-hydroxybutyrate the ketone that's used in you know the ketone esters is our beta hydroxy butyrate it's the naturally occurring form of beta hydroxy butyrate that we make from our own fat so it's a natural substance it's not a synthetic chemical that's produced in a lab and then you know it has numerous potential adverse effects because it's synthetic and it's you know not a normal substance that we would have so you know those are the kind of things I want to be able to educate physicians about so that they understand it and so that you know they they may have you know patients you know people with Alzheimer's you know like I said before the brain is dying there there is no option when you look at risks and benefits you know perhaps it may be worth trying if the patient wants to try it doctors are allowed to use medications off-label you know they can use ketone esters off-label but should become educated about it and you know just use it with caution I think a hundred percent and we'd love to support your work there so how do folks follow along with your work I know you have a website that has a lot of resources there oh yeah or do our listeners continue to learn about your efforts here so my website is coconut ketones calm I put that together at the end of 2008 you know after Steve responded I thought okay websites were getting popular now it was a pretty messy website you know for a long time but I've really worked a lot on it the last few months and so it's CO CO and u T ket o n es comm and I have Facebook page called coconut oil helps Alzheimer's dementia ALS and so people can tune in there I'm gonna probably have a new page soon that has a more keto kind of a title you know dementia prevention should begin in our 30s and Aikido you know going the Aikido route is one way to do that one important way and I'm talking about food and possibly exogenous ketones you know for people that are at risk so I want to have a page that I'll hopefully have up soon and Facebook and I'm doing a series Facebook live on Mondays through April in May we're talking about my book chapter by chapter sort of like a book club online and the times are be posted you know on my coconut oil helps ketones and on my ketone coconut ketones website so you know and I have a lot of articles I've written about the various types of exogenous ketones and using you know in the elderly and people with medical conditions I have that written app that people can actually read about it doctors can read about it nutritionists can read about it it's a wonderful inspiring story so thanks so much for taking the time to share that with us you're welcome thank you for letting me share it with you thanks so much for tuning in this week everyone if you want to learn more about HV MN and our offerings visit WWE TV MN comm forward slash pot also by writing a review on our iTunes page and sending a screenshot to podcast @ hv MN calm we'll hook you up with $15 worth of atrium and store credit our last shoutout goes to our listener survey which lets us know who you are better so we can continue making episodes that you find most valuable so visit go h vm n comm ford slash podcast survey for that it'll only take a few minutes and new submissions are eligible for an h vm and ketone giveaway it's well worth the time until next time study smart train hard and live well [Music]

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Keywords: ketones for alzheimer's, alzheimer's disease, healthcare science, coconut oil, mct oil for dementia, coconut oil for alzheimer's, dr mary newport, dr mary newport coconut oil, steve newport, coconut oil benefits, coconut oil benefits for brain health, fat for fuel, fat for brain health, coconut oil to treat alzheimer, treat alzheimer, coconut oil health benefits, dramatic improvement, memory loss, alzheimers, exogenous ketones, mct, mayo clinic, ketosis, uses of coconut oil

Id: BHVDMcJn2YE

Length: 82min 47sec (4967 seconds)

Published: Mon May 06 2019

Reddit Comments

[u/[deleted]]

Amy Berger's alzheimers as type 3 diabetes theory just keeps getting stronger by the day.

[u/nocrustpizza]

I really wish there was more amateur and professional and research testing on this. Also similar, such as fasting.

Just had relative die from cognitive decline. I did hint about it nicely. As well as can with being “that person” giving wack medical advice.

Answer, “Yeah, we are doing the Mediterranean Diet”

I didn’t push more. They had top doctors.

She went rather rapidly.