Receptor Tyrosine Kinase | RTK Signalling

welcome back friends in this video we'll be discussing about a particular type of receptors called receptor tyrosine kinases we will see the kinase activity of the receptor how the receptor receives ligands what type of transformation occur upon ligand binding how kinase activity is being driven in this receptor and finally we will see how it's getting activated to initiate the signaling pathway this all will be discussed in this lecture these receptors are kind of plasma membrane receptors and have an enzymatic activity the intracellular catalytic domains have the kinase entity and we know the enzyme that catalyzes the transfer of phosphate groups is the property of any kinase enzyme the intracellular domain acts as a tyrosine kinase which catalyzes the transfer of phosphate from ATP molecule to amino acid tyrosine on a substrate protein the opposite of tennis is an enzyme that removes phosphate groups from targets known as phosphatase now let's see in detail the ligand binding and the activation of articles these articles are embedded in plasma membrane the intracellular part is lodged with tyrosine amino acids as shown in the figure before the signaling molecule binds the receptor exists as individual units rapid as monomers as you can see in this picture they are both individual monomers separated from each other on the extra so little part it has got ligand binding site like this and to these sites the signaling molecule binds and initiates the activation pathway on the next step we see the binding of signaling molecules such as growth factor causes two receptor monomers to associate closely with each other forming a complex known as dimer in a process called dimerization but the dimerization does not fully activate their receptor molecules it needs phosphorylation which is achieved by the kinase activity of the receptor as it transfers phosphates from adp towards the tyrosine amino acids present on receptors as we see in their reaction now we have a phosphorylated diamond which is the activated form of receptor tyrosine kinase now that the receptor is fully activated it's recognized by specifically proteins inside the cell any such protein binds to specific phosphorylated tyrosine undergoing a resulting structural change that activates the bound protein we see inside the cell there are inactive early proteins which are getting recruited by this activated RTK once they get recruited by activated rpk the RPK changes their shape and activates these relay proteins after that each activated protein then triggers a transduction pathway leading to a cellular response so this is how articles are getting activated by ligands where Tiny's entity these particles are a large family of receptors which include the following major receptors first one is epidermal growth factor receptor family this is associated with signaling in nervous system as it's insufficiency in signaling has been related with neurodegenerative diseases the another being the fibroblast growth factor receptor family FGFR it receives the fibroblast growth factors which are a family of growth factors with members involved angiogenesis bone healing and embryonic development so this is all about the receptor tyrosine kinases I hope you liked the video if you liked it give it a thumbs up and make sure subscribe this channel Thanks

Channel: Hussain Biology

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Keywords: receptor tyrosine kinase activation, receptor tyrosine kinase animation, receptor tyrosine kinase dimerization, receptor tyrosine kinase function, receptor tyrosine kinase mechanism, receptor tyrosine kinase pathway, receptor tyrosine kinase phosphorylation, receptor tyrosine kinase signalling, rtk signalling, monomers rtk, why rtk dimerize, tyrosine kinase receptor, kinase activity, ap bilogy, hussain biology, rtk hussain biology, mechanism of receptor kinase, tyrosine signal

Id: 0mKZRAt0GZg

Length: 4min 23sec (263 seconds)

Published: Tue Oct 03 2017