Part 2: How Does New Genetic Information Evolve? Gene Duplications

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Stated Clearly presents: How do new genes evolve? As we've learned in previous animations a gene is a long stretch of DNA containing information that codes for something, usually a protein or a group of proteins. Point mutations can edit small bits of information within a gene. modifying the type of protein it builds small bits of information within a gene. modifying the type of protein it builds these small edits are extremely important for evolution but if we compared the genes of say, a flower to those of a dolphin, we see that even though they do have many genes in common, dolphins also have entirely new genes that flowers do not have. Flowers also have genes that can't be found in dolphins. This observation forces to ask the question: How do entirely new genes evolve? Point mutations are clearly not enough. Well, it turns out that over the years, scientists have discovered many natural mechanisms for the evolution of new genes. one of the most common and well-understood pathway is a duplication event followed by further mutations. A duplication event is a special type of mutation where, as you may have guessed, a stretch of genetic code is duplicated and reinserted into a creature's DNA. Duplications happen naturally all the time, they can be small, a few letters or nucleotides long. Other times enrtire genes can be duplicated, dramatically increasing the length of a creatures genetic code. During duplications and in the generations that follow, further mutations can occur in the new gene giving rise to entirely new genetic information. Information that codes for new proteins with new functions. Scientists have directly-observed duplication events in the lab many times over, because of this they can now examine the genetic code of any living creature, look for known signatures of past duplication events, and begin to piece together an understanding of how specific genes likely evolved. Here we'll look at three traits which arose from gene duplications. The dachshunds odd-shaped yet powerful legs, the unique digestive enzymes of leaf eatin monkeys, and finally, the evolution of snake venom! At first glance you might be tempted to think that the dachshunds short legs are simply a disability. To the contrary the unique shape of this dog's legs make it it a surprisingly powerful digger and most importantly, allow it to enter small burrows to coax out rabbits, groundhogs and even Badgers from their dens. Other dogs can only dream of such adventures. By looking at the dachshunds DNA, researchers have found that their unique legs are the result of a duplication event! A gene called FGF4 for was copied and inserted elsewhere in their DNA. The new gene happens to produce protein in a way that interacts with their growing bones, reshaping the dog's legs and opening up an entirely new hunting niche for the animal. Humans who liked the trait, bred the original dog with many others, eventually giving rise to several new dog breeds and proving that sometimes, even the strangest of mutations, within the right environment, turn out to be extremely beneficial! Now let's look at the fascinating case of the leaf eating monkey from vietnam: the Duke lungur. Several species of Asian monkeys eat almost nothing but leaves, a diet that would cause humans and most other primates major stomach problems. The monkeys achieve this amazing feat of digestion with the help of several adaptations, one of which was first made possible by a gene duplication. RNase1 is a protein found all throughout your cells and blood. Experiments have shown that this protein helps our cells fight against viruses by attaching to and breaking down virus genes. In your intestines, RNase1 does a similar task but for a very different purpose. There it breaks down genes from the cells of the food you've been eating, converting those genes into nutrients that your body can absorb. In humans, the pH or acid levels of your intestines are pretty much the same as the pH levels of your cells. This allows a single version of RNase1 to work great fighting viruses in your body, and digesting food inside your intestines. In leaf eating monkeys, however, the intestines are more acidic. this acid appears to be helpful for breaking down the tough cell walls of raw leaves, but unfortunately, the extra acid also slows down RNase1 proteins which are extremely sensitive to acid. Scientists have found that a relatively recent duplication in the monkeys RNase1 gene has fix this problem. The original gene still makes normal protein to help fight against infections, but the new gene, after being duplicated, began accumulating mutations that slowly made it better and better at functioning in acid. Here we have a clear case of a single gene that was once ok at two separate jobs, was then duplicated, and the two genes of since specialized to produce proteins for different tasks. Now for an exciting yet slightly disturbing example: The evolution of snake venom! Genes inside the saliva glands of most creatures, humans included, produce special proteins that are able to start breaking down food on a chemical level, even before it gets to the stomach. Venomous snakes, however, have taken this a step further. Their saliva glands produce venom! A cocktail of proteins and other molecules that kill their prey when injected. Let's see how one of these deadly proteins evolved, Many people assume that blood clots form when cuts are allowed to dry in open-air. Amazingly Clots actually form through a series of chemical reactions that can quickly seal the wound, even underwater. This ability is possible in part because of a protein called factorX. It's found in the blood of many animals including fish, frogs, snakes, birds, and even people. FactorX normally exists in a dormant or sleeping state, drifting about the bloodstream with no effect. When a blood vessel is cut, however, chemicals in the damaged tissue activate factorX at the scene of the injury. FactorX then initiates a series of chemical reactions, causing a clot to form in seal the wound. The saliva of the Australian rough scaled snake is loaded with pre activated factor 10 proteins! If the snake bites an animal, injecting its saliva directly into the wound, rapid clotting occurs throughout the victim's body. The result is often death! When scientists look at the genes that code for this protein, they see clear signs that the snakes very own factorX gene, the one that it uses in its own blood, was copied through a duplication event. After or during duplication, mutations in and near the new gene cause it to produce factorX protein in the venom glands instead of the blood. As time went on, small mutations built up in the duplicated gene, making it more and more efficient and its deadly new task! Here we see that a gene once used for healing, has now evolved to kill! So to sum things up - how is it that new genes evolve? One of the most important and well-understood pathways is for genes to duplicate and then accumulate new mutations. Gene duplications, in combination with similar mutations like insertions deletions and point mutations, are happening naturally right now, all throughout the living world. With these mutations constantly occurring and constantly filtered through natural selection, there are no limits to the variety of new genetic information, new traits, and new species that evolution can produce! I'm John Perry and that's how new genes evolve, Stated Clearly! This animation was funded in part by GeneTools LLC. They produced molecules called morpholinos that allow researchers to selectively silent any gene to investigate the effects on cell growth, tissue, and even cancer. Learn more on their website at gene-tools.com This animation is also supported by our contributors on Patreon! If you found this video helpful and would like to give back, visit us at statedclearly.com and click "contribute" to learn how. So long for now, stay curious!
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Channel: Stated Clearly
Views: 240,898
Rating: undefined out of 5
Keywords: genetic information, evolution, genetics, gene duplication, new genes, creationism, Darwin, Jon Perry, Stated Clearly, Nicholas Casewell, Snake Venom
Id: G4VINRUe_o4
Channel Id: undefined
Length: 8min 55sec (535 seconds)
Published: Fri Mar 11 2016
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