p53 Tumour Suppressor (2016) by Etsuko Uno wehi.tv

p53 tumor suppressor your body's cells and tissues are under constant stress from the environment such as DNA damage from UV light emitted from the Sun damage to your DNA causes cells to follow one of three outcomes either the cell dies stopped growing permanently or slows down to repair before resuming normal growth the protein p53 plays an essential role in determining this fate p53 plays a critical role in keeping cells healthy on our bodies cancer free half of all human cancers of p53 switched off p53 is found in the nucleus of each cell responding to DNA damage p53 activates distinct sets of genes that drive processes such as cell death DNA repair or growth arrest and this is what determines the outcome of the cell the activation of genes involved in DNA repair has been linked to p53 x' ability to suppress cancer in the nucleus DNA is wound around histone proteins to create chromatin genes are encoded in your DNA p53 targets specific genes controlling whether they are turned on or off via their DNA promoter the DNA promoter contains a part specific for p53 known as the p53 response element the stars of the gene is found within the core promoter p53 binds its response elements and helps bring RNA polymerase to the start of the gene RNA polymerase is the enzyme responsible for reading and transcribing for gene code this p53 target gene is currently off RNA polymerase is not reading the gene code the amount of p53 increases in response to UV induced damage from the Sun [Applause] the highly dynamic p53 protein is made of four identical parts each part contains a DNA binding domain p53 binds DNA all four DNA binding domains combine the response elements in the promoter of target genes to turn the gene on p53 does two things first p53 makes the gene more accessible by recruiting proteins that remodel the DNA second p53 brings RNA polymerase to the now accessible target gene now switched on the gene will be read and transcribed by RNA polymerase activating pathways such as soda growth arrest or DNA repair

Channel: WEHImovies

Views: 82,991

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Id: 6SjkIYClAkQ

Length: 5min 41sec (341 seconds)

Published: Fri Jun 26 2020