Nanomedicines: Materials, Manufacturing & Therapeutic Applications | James Taylor, CEO, PNI

all right welcome everyone to the first annual nanomedicine symposium very exciting all right this one is entitled materials manufacturing and therapeutic applications so thank you very much for everyone for attending uh we're very fortunate to have uh such engagement here we're very excited about that um you know very excited also about the rapid growth of this field so it's very very cool a really neat time for us and i think for the field in general so we will be starting this poll this um my talk with a poll and the question i want folks to put in is what are the main reasons that brings you here today so please pull out your your your phones and answer these questions you can either pick network with researchers learn what scientists have recently developed with the nano assembler technology curious about new formulation techniques for nano medicine medicines learn more about cell transfection methods uh learn more about tech or none of the above we'll let that percolate uh-oh someone's winning cool has everyone got it in and if you are not participating you can't get the app try to get the app because we'll have lots of these questions throughout the day and it's a lot of fun all right cool great well it's good this is really good good to see that uh you know the big winner here is for us to to continue to to build our community and to to meet each other it is a small community of i think a lot of folks know each other it's a fantastic uh area to work in so i'm going to continue on here has everyone got the app going good we're good awesome all right so first and foremost it's it's a absolutely fantastic time in medicine new therapeutic modalities in the area small molecule drugs proteins and even new nucleic acids are really enabling us to modulate biology and treat disease at the molecular level allowing us to really treat and affect disease in ways that we we never have been able to in the past and for example shown here just some of the what we call the genetic toolbox this is a suite of molecules that allows us to turn genes off turn genes on and even to edit genes very sequence specifically to really get at the heart of disease at the genetics and molecular basis of disease and the power of these technologies and a lot of the other therapeutic small molecule protein technologies is really unprecedented and the power cannot be understated however the key challenge for this technology and for many other small molecule and protein based therapeutics is that they need to be delivered directly to the tissues to have their effect and into cells to have their effect and this is not going to happen by putting a little piece of dna in a big drug capsule like shown here this is going to happen with this technology with nanomedicines and why we're all here today so nanomedicines are a tremendously powerful technology that its job is to package and deliver drugs and take them directly to the tissues and into the cells to have their effect it's a very sophisticated technology where tens to hundreds of thousands of molecules need to come together to create the final drug product to have its effect and to do its job and and how that drug product comes together how these nanomedicines really self-assemble to create the structure is very important in the final product itself and how well that works and how efficacious it is at precision nanosystems we're tremendously passionate about the field of nano medicines and our mission really is to accelerate the field as a whole to provide tools and technologies to allow biopharmaceutical companies academic researchers and alike to really push forward this technology we think it's tremendously important to improve the human condition and push these technologies forward push the envelope of what we can make in nanomedicines and to bring these important drug modalities to patients to treat disease our contribution to the field has been the development of the continuous flow microfluidic manufacturer of nanomedicines so using the physics of small scales we're able to exquisitely control the physics and chemistry of how those self-assembly processes happen i think we'll hear about about the technology in various talks today so i won't spend too much time on it but we're very fortunate that has been a very successful technology and many folks here and in the field are using it to develop their nano medicines and primarily through our what has been our flagship product the nano assembler bench top instrument which is has been a great product for us here as un indicated we're very excited to really be unveiling our next suite of instruments and we're tremendously excited to be now deploying what we call the nano assembler family of products and and this is these have been designed really to move with our users to go from the earliest stages of development from drug screening through pre-clinical testing and then to bring those drugs into the clinic for clinical trials and then further to put on the marketplace so at the small scale we have our new nano assembler spark this is a really cool instrument that allows us to make nanomedicines very high quality very good nanomedicines at volumes as low as 25 microliters and up to 250 microliters this is very important when we consider things like screening um either the drug itself or the nanoparticle components and doing that efficiently but also is tremendously simple to use and you'll see it soon uh one button one click of a button able to make very high grade nanoparticles in under 10 seconds the next instrument is the nano silver bench top with many many of you are familiar with this system really excels at developing rapid candidate development prototyping early drug candidates it operates in the one milliliter to 15 milliliter formulation range which is an ideal range for doing development and doing size characterization various physical characterizations of the particle plus moving into small animal studies and it has all the functionality all the process control parameters we may need to really modulate the characteristics of our nanomedicines to develop new and novel and exciting exciting nanomedicines the next instrument is our new nano assembler blaze and this system really is positioned to allow folks to carry their drug products towards the clinic allows for manufacture uses continuous flow manufacturing pumping systems to allow us to go from 10 milliliter formulations to one liter formulations in a continuous flow format very useful for things like larger toxicology studies as well as for early cmc investigation and the like and finally we're tremendously excited something that many of you may know we've been working on for the past couple years is our gmp system and we'll talk about it today and this is a system that allows us to take your pre-clinical develop uh nanomedicine candidates push them towards the clinical for clinical testing and eventually uh to to treat patients on the marketplace so very exciting for us um and one point with this is the the technology uses all the same microfluidics so the translation as we go from instrument to instrument really is seamless and

Channel: Precision NanoSystems is now part of Cytiva

Views: 9,862

Keywords: nanomedicine, precision nanosystems, nanoassemblr, precision medicine, gene therapy, microfluidics, science, nanoparticles, polymers

Id: uJ9ObSzWRB4

Length: 7min 45sec (465 seconds)

Published: Wed Sep 14 2016