HDL & Reverse Cholesterol Transport [HD]

reverse cholesterol transport is a pathway for plaque reduction the key mediator of this process is HDL HDL is a particle that transports cholesterol and it's production starts in the intestines and the liver lipid pour a PO a 1 is secreted from the leather and intestinal cells and released into plasma for circulation to peripheral cells a PO a one thought to be largely responsible for the anti atherosclerosis properties of HDL makes up 70 percent of the protein on HDL and is found on virtually every HDL particle some of these particles will reach the heart where they enter the vessel wall and come in contact with cholesterol rich foam cells which are part of the atherosclerosis the lipid poor apo a one protein interacts with abca1 thereby developing the nascent HDL particle which then interacts with the transporters ABC g1 and s RB one to develop into a mature HDL particle as it contacts foam cells HDL accumulates cholesterol becoming a cholesterol rich ester as it matures the nascent and later mature HDL facilitate a flux of cholesterol from the peripheral macrophages enabling reverse cholesterol transport mature HDL delivers cholesterol to the liver through two pathways a direct pathway and an indirect pathway through the direct pathway HDL interacts with a receptor SR b1 on the liver allowing the delivery of cholesterol the resulting lipid poor HDL particle can then be recirculated where it can repeat the process of reverse cholesterol transport HDL also passes cholesterol to the liver through an indirect pathway via cholesterol ester transfer protein or CET P CET P facilitates the exchange of cholesterol and HDL for triglycerides in the triglyceride rich a poby particles VLDL and LDL in this one-to-one exchange HDL reached with triglycerides and LDL with cholesterol LDL particles may go into circulation or interact with LDL receptors at liver cells where LDL particles may deposit the cholesterol ester content at the LDL receptor after cholesterol is delivered to the liver by either pathway it is processed or secreted into the bile and carried to the intestine HDL plays a critical role in reverse cholesterol transport by delivering cholesterol from plaque in the peripheral macrophages to the liver or it is processed for excretion from the body the net effect of HDL in the reverse cholesterol transport pathway is the removal of cholesterol from plaque and the potential reduction of cardiovascular risk

Channel: Tagouz

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Keywords: High-density Lipoprotein, HDL, HDL-C, High Density Lipoprotein, Reverse cholesterol transport, Cholesterol Efflux, Good Cholesterol, CETP, Apo-A1, Apo-B, LDL, LDL-C, Cholesterol, Atherosclerosis (Disease Or Medical Condition), Niacin (Drug), HDL Animation, Animation, Lipids, Reverse Cholestero Efflux, Medicine (Field Of Study), Health, Medical Animation, 3D Animation

Id: q0YiPqmsXRg

Length: 3min 23sec (203 seconds)

Published: Fri Oct 18 2013