(upbeat music) - Hi and welcome to another
Fullscript sponsored educational webinar. I am Dr. Holly Lucille. I'm part of the Innovative
Medical Advisory Team at Natural Partners Fullscript and it is my distinct pleasure to have back with us, Dr. Ben Lynch. Now Ben, I'm gonna give
the folks out there and maybe the two or three folks that have never heard anything about you. Just a little bit of
a rundown of your bio. But I do wanna throw it to you to have us know what's up in your world, because I know that, you're up to way more than what's on this little piece of paper. (laughing)
And you've walked so much more than what's on
this little piece of paper. - I hope so. - Yeah, let me just get started. So, Dr. Ben Lynch, M.D., received his Cell and Molecular Biology Bachelor of Science degree from the University of Washington and his Doctorate in
Naturopathic Medicine, from Bastyr University. His passion for identifying
the cause of disease. I love that story. Directed him towards nutrigenomics and methylation dysfunction. Currently, he researches, writes, presents on a worldwide of topics of
MTHFR, methylation defects and genetic control. So, thanks for being here once again. - Yeah, pleasure to be here, Holly. Always good. - You know, every time I talk to you, I get a chance to talk to you, every time I hear you speak, every time I read anything you've written, I learn something and I don't think that today is gonna be any different, especially with our title. You know, glutathione, why it doesn't work. But before we get into that topic, especially the why it
doesn't always work part. Yeah, tell the attendees just what's up with you, more about you, you're so prolific in your work and I always appreciate it. So, take it from here. - Yeah, well thanks for that. So, yeah like you said, there's always more to
us than our little bios. But, I would say right now, I'm working hard on getting
a routine established for myself and my family. We have been out of
our home for two years. And we just moved back and that home construction job experience, was very, very informative about our environmental exposures - Wow.
- and I will tell you, even though I was drilling our builders about all these different
things to use and not to use, things still slip by. I wasn't aware of them, or I told them and it got installed anyway and then it'd be ripped out. And things I had no idea, that I found by chance. And thankfully, I had good people, who helped me out and protect my family. But I will tell you, do not forget our patients and ourselves are living in a box, the majority of our lives and we're the only species on the planet, that builds stuff like this, out of unnatural materials and we have to be very, very mindful that the environment
should be coming first and be always, always asking, you know, your patients, "Have you remodeled recently? "Did you move into a new home? "Did you recently move? "Where did you work? "Has your office been remodeled? "New carpets, new anything." Because this ties into glutathione too. - Oh, absolutely. I mean such, I mean as you said, it informed you quite a bit. I actually see your next book. I see the title. I see the cover. (laughs) Because,
- Yeah (laughs). Yeah. - Just living life is the best way you get information, that is for sure. So all right. Let's get into glutathione, because I was, you know,
why it doesn't always work. I mean we love glutathione. We think about glutathione, "Glutathione, right?" It's this huge, major antioxidant responsible for so much and of course when you're talking about environmental exposure, very important. We love it in all its forms. So, let's just roll
back to the basics first and talk about what the
heck is glutathione? - Well glutathione is one of our body's top antioxidants. And, we have to also define
what an antioxidant is, you know, it's something that
takes our oxygen molecule and makes it less reactive. So, glutathione is a, it's a three part amino acid. It contains glutamine,
glycine and cysteine and it combines them all together. In order to do that, requires multiple genes
and it's a lot of work for the body to produce this compound. It's not easy, you can't
just tell your patient to eat a bunch of protein and hopefully they absorb it and they're not taking in acids and they're actually chewing their food and not drinking a bunch of liquid when they're eating. But, consuming protein and absorbing it, but glutathione itself
is a three part protein. It's synthesized by multiple genes. It actually comes from also homocysteine. So if your patient's homocysteine is high, or if it's low, you know, that's telling
and a lot of people, I'm gonna deviate here real quickly, because this is a huge issue. There is no low normal. There's no low value
on a homocysteine lab. It's always greater than you
know, greater than 15 is bad. And that's too high. But if a Homocysteine is less than five, how can your patient
be making glutathione? So, can they all see the screen here? - Yep. - Okay. So here is homocysteine right here, okay? Here's homocysteine and follow the arrows, it comes down and here's cysteine. And then here is your
patient's glutathione, okay? So if your patient has low homocysteine, too low, i.e. less than five, how are they gonna be making glutathione? So here's that tri-peptide. So glutathione is basically,
it's job is to neutralize hydrogen peroxide, as an antioxidant. But it does other things too. It helps neutralize and pull out arsenic. It helps neutralize formaldehyde. It helps neutralize chlorine gases. So it does a lot of other things as well. - So extremely important, obviously. As practitioners, we use it all the time. But from your knowledge base, what form of glutathione do practitioners usually use and why? Why do they choose that form? - Well, I think it's whatever
the practitioner is using and for that's most convenient for them. So for me personally, I like to use liposomal glutathione. Some practitioners are IV. And their clinics are set up for IV, so that's what they use. You know, it gets right
into the bloodstream. It bypasses first effect. You know, it doesn't, so that the liver doesn't destroy it. Some practitioners like
S-Acetyl glutathione, because they like selling capsules, or like providing capsules
to their patients. S-acetylglutathione is useful, because it has an acetyl group bound to the glutathione, so when the patient
swallows the glutathione, the stomach acid doesn't destroy it, it just cleaves the acetyl
group from the glutathione and then the glutathione can be delivered into the system. Is it useful? Yes, S-acetylglutathione is useful. There's also topical glutathione. So topical glutathione is also useful, like IV, in that, it
doesn't hit the microbiome. So when you, anytime you swallow something, your patients swallow something, it's gonna be impacted by
the microbiome, eventually. Since glutathione is a sulfur compound, so cysteine is very, very high sulfur. And cysteine is very, very reactive. So, the microbiome will get a hold of it, and SIBO is everywhere. So, we have to be mindful about that too, before I get into the side effects. But I say that there's a plethora of different ways and you
talked about earlier, Holly, before we jumped on here, about the probiotic special sort increasing glutathione as well, right? - Yeah, so I mean I've heard that lactobacillus fermentum, I think it was me-3. Was a strain that was actually able to increase glutathione production. - Yeah and you know, so when we hear these things, it's very useful, but, first of all, we have to quantify. - Right. - You know, how much glutathione
are we talking about? - Yeah, it sounds good
when you say it really fast (laughs), especially
- Yeah. - From precision probiotics. - Right, you know, you get really excited and it's like, oh, this
lactobacillus fermentum me-3, makes glutathione and you're gonna give it to your patient and then
your patient gets worse, and then you're like, "What the heck? "What just happened? "Is it from too much glutathione? "Are they detoxing? "Or is it something else?" And lactobacillus fermentum, as we were talking earlier, listen to the specie, right? Fermentum.
- Fermentum. - It ferments. And so then if you have
something fermenting, it's going to be producing histamine. And so, is the histamine production actually what's stimulating
the glutathione production? And I don't know. That's something I need to research, because since you said that
lactobacillus fermentum, see I always think mechanism's action. - Right. - So is the lactobacillus fermentum actually producing glutathione, or, is it stimulating histamine, which is stimulating glutathione? I don't know. Maybe it's both.
- Right. You know I'm glad I brought it up. I mean I heard about it and once again, I think you make a great point here that, as I said, it sounds good
when you say it really fast, but I think that, you have to get in there to understand the mechanism of action, because, based on case by case, you could be actually introducing it and making the situation worse, especially if SIBO is on deck, for sure. - Yeah, or the individual's histamine metabolizing enzyme in their gut, is overwhelmed from
histamine producing bacteria. Like blastocystis hominis. You know, blastocystis
hominis is identified by doctor's data and other labs and if you're carrying
blastocystis hominis, and it's pervasive in our water, and our foods and I had it. And I recently tested
using the GI map test and it's gone, thankfully. But doesn't mean it can't come back. But I was really, really burdened with high histamine symptoms. And so, other microbiomes, or microbes can be producing histamine. Or things like methotrexate, or amiloride. These are two commonly prescribed meds, which also reduce the
histamine metabolizing enzymes, to be able to work. So we digress to histamine again. (laughing)
But, it's a big issue. - It is. And just to take a quick
break for attendees. I know you probably are
gonna have questions, so please take advantage of the chat box and ask them and then Captain Kim, who is running this webinar, will be Slacking them to me and I'll be asking them to Dr. Lynch, to get an answer for you and if we don't get
through all the questions, we'll definitely try to
get all of the questions answers to you, after the webinar as well. So Ben, you talked about,
briefly you mentioned quickly in a sentence, side
effects, of glutathione. And I'm sure part of my brain and some of the other attendees went, "What are you talking about side effects "of glutathione?" Because, as you say, it's a really important compound. We need it especially in our modern day, you know it better than most right now, because of what you just went through in building probably one
of the cleanest houses that are out there, because you had your mind around it and you had your eyes and ears open. So it's needed with our
environmental exposure, but what are you talking about
when you say side effects? - Yeah, so first off, I don't wanna give glutathione a bad rep. I love glutathione. It's phenomenal. But Holly, you made a great point. What we love, doesn't always (laughs), make it gonna be perfect for us. I love my kids. (laughing)
But sometimes, they're a real pain, you know? - We could go on and on
and on with analogies, I promise you.
- (laughs) Yeah, so I mean there's
many, many examples. But, you know, at some point, glutathione, has affected your patients, 100%. And I guarantee you, it
is not a detox reaction. It's something else. There's other mechanisms
of action at play here. And I'm going to be
giving you a few of them, because when I researched
this and I found evidence in published research, I was like, "Wow this is actually really cool." And it made me more cautious
about using glutathione. So, some of the side
effects of glutathione. I surveyed a number of
people and about 300 people, 281 responses I got back and it confirmed the side effects that I saw clinically and
just from others in general. So, in order, headache, 33% responded. Anxiety, 28%. Fatigue, irritability, also 28%. Muscle pain, 15%. And then there's like eight others. Insomnia, rashes, itchy skin, difficulty breathing. You know, worsened skin issues and so on. Those were not as prolific though, so I didn't write those down. So but those are the main ones. Headache, anxiety, fatigue,
irritability and muscle pain. But Holly, which of those sound all very similar to you? - Well, they sound as you
said, like a detox reaction. Like, "Oh, we're doing a good job. "This needs to happen, we
just need to push through." - Right, exactly. And that is what a lot of us tell, or told our patients. - It's gonna get worse
before it gets better. It's a healing crisis. - That's right. It's like the homeopathy
healing crisis, right? And sometimes that does happen, you know? But, I have totally
changed my mindset on this. If the patient or the
individual I work with, does not get better, always, then I'm doing something wrong. - Yeah and I love that because, I think it's so important that
that guides your thinking, because, best laid plans, right? Based on your experience, your knowledge. But, you know, when the body is the best biofeedback machine, it's gonna tell us. So you always have to keep going back. Hey, where are the obstacles to cure? Where do we need to pivot and tweak this clinical situation and therapy? Let me ask you, the survey, this intel, this evidence, is pretty profound and like I said, I'm learning something and I think all of the attendees are as well, because it will change
the way that we practice, especially in using glutathione, because I think these days, we all do. Was there a certain dosage
that you had people on? Was this anything more specific than just somebody being, was there a certain type? Anything else that you found, that could inform us?
- Yeah. So I asked them, what are your current conditions right now? And so, that sets the stage. - Right.
- So my first question to them was, and I'm
happy to send the survey to you all, as well. So I can export the
survey from SurveyMonkey and I'll just, withhold the emails and names from them. Would you like me to do that? - Sure, that would be great. - Yeah and so the, you know, autoimmune disease was number one. Muscle cramps was actually number two. - Right.
- In terms of prevalence. Irritability, MSG sensitivity. And headaches. So, and I asked these questions because, I was a bit biased in the conditions I put there, because I had already studied
the mechanisms of action, of how glutathione could
be problematic for people and I suspected a lot of these pre-existing conditions
would actually flare, would become more flared and these individuals would be more flared from glutathione. And you're hearing these things and you're like, "Well, glutathione "has helped a lot of
my patients with this. "You're full of it." Well true, it does help a
lot of these individuals. But some will be worsened from it. - And why does that happen then? Why? What's going on? - Yeah, it's a mechanisms of action. So, the irritability, the headaches, the MSG sensation, the insomnia, all have to do with glutamate. Now there could be other
things going on here too. And there always is, because the body is crazy complex. But, glutamate, elevated glutamate, will increase these things, as we know. So, and glutathione, is produced from what? Glutamate, glycine and - Cysteine, yep. - Cysteine, thank you. So, higher levels of glutamate
will cause these problems and then some of these
individuals will already have kynurenic levels of kynurenic acid. Or however you say that crazy word. So if you order organic acids.
- Right, (mumbles) (laughs). - Yeah, it's a crazy one. But it's,
- But that way - So the--
- we didn't want it to go down. - Yeah, so if they have
brain inflammation. Pre-existing brain inflammation. So their kynurenic acids are already high. They have headaches, they
have all these things. And you give them glutathione, look what happens. So here's the, uh, gotta see here. So here's glutathione, right here. Okay, ah, come on. - Got it, got it, got it. - [Ben] Okay, so glutathione, will feedback inhibit, see this, I know it's a
bit backwards for you guys. But here's glutathione and it
feedbacks inhibits this gene. So as you feedback inhibit this gene, you are increasing cysteine levels. - Right. - [Ben] And cysteine levels, if the individual has oxidative stress, it's gonna turn the cysteine to cystine and make a reactive nitrogen species. So if they have higher iron levels, if they have higher levels of super oxide. Or what have you, or
they're fighting infections, or what's going on. You know, various things. Then that cysteine which now can no longer be making glutathione, is
gonna become more reactive and, at the same time,
cysteine has to be eliminated, and as it's being eliminated, it becomes sulfites. - Wow.
- Okay, the cysteine becomes sulfites and elevated sulfites, lead to breathing disorders, if you've ever done IVs on a patient with glutathione to a patient and you've seen them have
difficulty breathing, could be the sulfites. And sulfites increase
glutamate in the brain as well. - So when you said that gene, this gene, what gene was that? - So glutathione feedbacks
inhibits the GCL gene. - Okay.
- And I forget the name of that gene. - Okay. - But that gene, is
also inhibited by mold. Mycotoxins. - Yeah. - So.
- So. - Mycotoxins inhibit the
formation of glutathione, via the inhibition of the GCL gene. And that is from a published paper. - Yeah, all right. So this makes sense, given that pathway, that if there is a variant, or a gene that's inhibited
that people wound end up with these symptoms, so it informs I think the
clinical case even more to maybe dig deeper for data,
on a DNA perspective perhaps, but when you find this out, what do you do about it? - Well I look to, first I
suss out all the reasons why the individual has
higher glutamate levels. - Right.
- And, because glutathione by itself, 500 milligrams of glutathione, is not that much. - Right.
- So and the amount of glutamate that's
in there, isn't that much. So they had to have
something going on there. Another thing I wanna share is, there's kind of a curve, and I don't have it in
front of me at the moment, but a little bit of glutathione, too low of glutathione in your patient, will increase glutamate
levels in the brain. Because, I know I'm giving
you a ton of information here, but you can listen to this later, right, so just bear with me. I'm just dumping. - We're gonna go down. We'll get through this together. - Yeah, yeah. This is a lot of information, so just roll with it and
listen to it again later. I'm giving you a lot of
little actionable things that you can apply. So too little of glutathione in the brain, will increase calcium release and calcium release is
inflammatory, it's destructive. So too little is bad. And glutamate will increase
calcium channels to open. So that's bad. So too little of glutathione
will increase calcium channel and glutamate and too high of glutathione, will do the same thing. It's the three bears. You need just the right amount. - Yeah.
- You need just the right amount. And so how do you control that? I love using liposomal and
I love informing patients about the pulse method. The pulse method is, understand the symptoms of
why you need glutathione. For me, it's a foggy
head, not clear thinking. I don't know, I'll take a few drops, a quarter teaspoon, half a teaspoon, depending on the significance of it. Then maybe the next
day, I'll tune in again. How's my head? It's fine, I don't take it. I don't tell my patients,
(sirens blaring) or I don't see patients anymore, but, I always informed them to
tune into how they're feeling. Instruct them on what the supplement that they're taking does. What symptom that's supposed to alleviate and if they do not have that symptom, they skip taking that
supplement at that time. - So you mention the
liposomal glutathione, because you have best control over dosing. - Yes.
- Based on this three bear analogy. - Yes, yeah, because
for me and many others, if you take a liposomal glutathione and you squirt it in your
mouth, just a few drops and you hold it, I can literally feel my head clearing. I mean it's amazing. It's very fast. And so patients who have EMF sensitivity. Wifi sensitivity, low glutathione, because this EMF and Wifi
stimulate calcium channel release, so they have too little glutathione. You give them electrolytes
and you give them liposomal glutathione,
their EMF sensitivity goes way, way, way, way down. I've nullified mine. - It's so amazing that you said that, just see, this past weekend, I was at the California
Association Educational Conference called, Cells Gone Wild. It was all about autoimmune disease, but I had been in a little
bit of a travel swell. This was my third trip in
like a week and a half. I luckily was able to
just drive to Palm Springs and not get on a plane. But, you know, so early, start at 7:30. The exhibitors are there. I literally went up to somebody and said, "What can I, I need something." I felt and I almost could
not articulate but I'm like, "I just, I need to start, - Yep, yeah.
- "clocking in "and taking things in "and getting through the day." And that's exactly what she gave me. She gave me some liposomal glutathione and just like you said, hold it, it was right there
and it was almost instant. - Yeah, it's unbelievable. When it's the right thing, it nails it. Sometimes, it's deceiving,
because you take it, you hold it and nothing happens. When that happens, sometimes I'll stop and well I usually do stop and then I'll come back and it's like, "Eh, I need to take more." I'll take more and sometimes it does help. Other times, it doesn't. Then when it doesn't help, then I take electrolytes. When I take the electrolytes, that makes a huge difference. Does it make it completely go away? Sometimes not, because sometimes I'll be just surrounded by Wifi or Bluetooth for a long period of time,
maybe a week, at a conference. Because I don't have Wifi in my home. I'm wired. Everything is wired in this home. I'm shielded with aluminum
roof and aluminum siding and double glazed windows. My cell phone reception is horrible. (laughing) - And that's okay. - That's okay. But, yeah so, anyway, I digress a little bit. But that is very, very useful, because Wifi is a thing. You've got to tune in to
that with your patients too. - You know, so okay, from
a clinical perspective, because obviously we
don't wanna scare anybody about glutathione and using glutathione. When it comes to actually then prescribing glutathione, is there a prep that should happen? Is this a new conversation
- Yes. - that we should be thinking about having with our patients, based on the intel and the evidence of DNA genes being down regulated, et cetera? - Yeah, so you're spot on and I'm gonna share with the ones I know and obviously, I can't
share the ones I don't know. But, you know, I just wanna state that, because I don't know all the reasons why of what to do prior and
what are all the potential side effects are either. But I do know that, microbiome is a massive one. And sulfur is a huge one and when I surveyed these folks, I said, "Have any of
you taken molybdenum?" There was like 80% have never tried it, using molybdenum. Molybdenum is the co-factor
which gets rid of sulfites. - Right, molybdenum, - And this--
- right. - Yeah and this gene is slowed down by, I have it here on my pathway planner, is slowed down by arsenic and tungsten. So, look, there's, we always concern ourselves about genetics and running genetic reports. But that book over there, it's more about the environment. It's more about dirty genes. It's not just about inheriting which snips cause a slow suox. Suox, S-U-O-X, is the gene which processes sulfites into sulfate and
then you pee them out. If this gene is slow for any reason, whether it is a genetic bimorphism. Or a co-factor deficiency of molybdenum. Or an environmental sluggishness, caused by arsenic, or tungsten and others, which I don't know about, then you have to evaluate them all. Water filtration is a big one. But I would definitely
start with molybdenum. That is inexpensive and easy to use. You know at Seeking Health,
I believe you guys carry the molybdenum drops. It's 25 micrograms per drop and that's all that's in there, basically. - So this would be a preparatory phase. - Yes.
- In instigating glutathione. - Yep and also, a great question is, a great preface is, "Do you get headaches "from drinking red wine,
or cheaper alcohols?" "Yes." "Do you get insomnia from that?" "Yes." "Do you get headaches from." Well not headaches, that's different. But, there's a lot of sulfites in wine. Or just ask them straight up, "How do you handle sulfites?" "No,
- Right. - "I can't handle them." And that's different than sulfur drugs. Sulfur drugs
- Right. - And sulfites, different class. - Good distinction. - Yeah, so give them molybdenum. Be mindful though, that as their symptoms improve,
they stop the molybdenum. So it's, the 25 micrograms is not much. We also have a capsule of 500 micrograms, which these people are pretty
overwhelmed with sulfites, so giving them a 500 microgram capsule, can really help them as
they improve, improve and their symptoms go way down, you stop the molybdenum. If they're ingesting a
lot of sulfur based foods, or sulfur based supplements, then you go back with the molybdenum. But if
- Okay. - they're not, you stop it, because molybdenum is
also the co-factor for making uric acid. So if you see a high uric acid on a lab, be careful, because you
might be pushing that. - Got it, okay. So yeah, it makes sense that
I should mention as well for the folks, you are
President of SeekingHealth.com. Definitely pushing things out to help wash off genes,
with your book, Dirty Genes, I just want everybody to know, if you're attending this
webinar in a live fashion, you will be entered
into the random drawing and win a copy of Ben's book, Dirty Genes.
- Okay, cool. - An excellent book. Changed the way that I think and practice, for better outcomes. It just is a must. If you win it, read it. If you don't, buy it (laughs), that's what I gotta say there. - Awesome. - So okay. Any other thing besides molybdenum, when it comes to
- Yes. - The prep, when we're
- 100%. - Thinking about now,
- 100%. - Cautiously, (laughs) giving glutathione? - Yeah, so my foundational
thing is electrolytes. 100% hands down. Electrolytes are massively important. 99% of women are potassium deficient. 90% of men are potassium deficient. Most elctrolytes do not have
sufficient potassium in there. We need about four to five
grams of potassium a day, in divided doses. You have to be very careful
with potassium dosing, for various reasons. But as long as potassium
is taken with food, the risk for overdosing goes way down. It's an empty stomach,
which is the biggest issue. But our Optimal Electrolyte has
500 milligrams of potassium. Has a lot of magnesium and
ribose and other things. But the, remember when
I surveyed those folks, the top two pre-existing
conditions they had, was one was, autoimmune problems. Number two was muscle
spasms and cramps, okay? So, just dehydration in general. Because dehydration is
going to concentrate whatever metabolite your patient has. Your body cries for water.
- Yeah, I'm surprised, as foundational as hydration is, how many people after
an adequate assessment in my practice, are
frankly just dehydrated. - Oh yeah. They ignore it. They ignore it.
- Completely. - Then they're tired. So get this. The first sign that I know I need water, is I get a little bit of fatigue. - Yep.
- Just a little bit of fatigue. It doesn't take much of
dehydration to get brain fatigue. So they drink something that typically dehydrates them further. They get some caffeine or sugar, which is further dehydrating. So you hydrate your patient
and I can't tell you how many stories I've
heard, over and over. People just come up to me when
I go to conferences and say, "I feel so much better
with the electrolytes now." It's just amazing. - Drinking water and having
electrolytes on board. It is amazing (laughs). - Yeah and water is not hydration. Water is water. Hydrating is getting
water inside the cell. And getting electrolytes inside the cell. But that's a whole nother topic. So but I start with electrolytes. I start with molybdenum and then I use the co-factors for recycling glutathione. Also, a compound like PQQ, to neutralize reactive oxygen species, because if your patient has a lot of reactive nitrogen species, or reactive oxygen species, whatever cysteine is
accumulating or glutamate, is going to cause more havoc. So by giving a supplement of PQQ, you're neutralizing a
ton of free radicals, which is going to make the
glutathione less damaged and also by giving riboflavin, you're going to recycle
the damaged glutathione, because glutathione is reduced, which you've heard, reduced
glutathione, that's good. Once it neutralizes
hydrogen peroxide or arsenic or formaldehyde or chlorine, then it becomes oxidized glutathione and that is very harmful stuff. Very harmful and it has to be recycled by using riboflavin. I can't tell you how many times I've seen deficient riboflavin on patients' organic acid labs. It's pervasive. - Right up there with the
presentation of the headache, you know, I would say. - Bam, exactly. - So this is all paving the
way to get the best bang for your buck, per se, when
you want to give glutathione. - Yes. Yeah and so in all this time, I've been mindful of the
glutathione side effects, for a long time, I mean even ever since you know, I was in, as a clinician, a student
clinician at Bastyr. I saw my first sulfur
side effects from DMSA. DMSA is a similar thing. You see body rashes, you see headaches, you see intolerance,
you see sulfite excess. Molybdenum for neutralizing DMSA, which is now pulled, unfortunately. But, so I formulated optimal
liposomal glutathione, plus with these co-factors. It's got the PQQ. It has, oh I forgot one. Selenium. Selenium allows the use of glutathione. So if you have the glutathione, but you do not have the selenium, the glutathione's just gonna sit there and it's not gonna be able to neutralize the hydrogen peroxide, because, the glutathione peroxide
gene, requires selenium. So the glutathione, if it's just sitting there
and it can't be used, it's gonna get oxidized eventually. So you have to have sufficient selenium, but not too much, because too much selenium is also toxic, because it's a metal, or a mineral. So you have to be careful with those. So, optimal liposomal
glutathione's got selenium. It has the PQQ. It has the riboflavin and
it has the molybdenum, all built in, along with the ribo, or along with the glutathione
and the phosphocholine. I'll warn you, it's not the best tasting. The optimal liposomal glutathione mint is my favorite one. But the plus is definitely helping a lot of people who were otherwise unable to take glutathione. - Well I think from a patient
adherence perspective, that's the old dossier. You know, this is doctor is teacher. It's like, "Hey, the risk benefit ratio." I've had this conversation sternly with a couple of my patients, where they were like, "You know what, "that tastes like crap." I'm like, "Well guess what? "(laughs) Get over it. "Because, this is what we need to do. "The risk benefit ratio, of
you having this on board, "versus your taste buds
getting a little burdened "for a bit of the day, is just, "it's the benefit is there." - Definitely and that was also one of the I think a lot of people
in the survey commented, they said, "You know, I don't
care how gross it tastes. "The outcomes are so huge." Then there's other people said that, it was a minimal, it was like 3%, I think. "It tasted so bad, I won't touch it." It's like, "All right,
you know, so be it." - That's the obstacle to cure, but. - Yes, yes, yourself (laughs). - (laughs) Well in so
many different cases. All right. I wanna back up then
and I wanna talk about, I know it has been
common for practitioners to actually just provide
the building blocks of this compound, you know. So in the form perhaps
of N-acetylcysteine. What do you think about
that, what do you see there? (sirens blaring) - There goes a glutathione
side effect issue. No (laughs). No so N-acetylcysteine's wonderful, when it's used properly. I learned from early on
too, NAC makes glutathione. When you look on this pathway. - Right. - [Ben] So here is your cysteine. Eh, everything's backwards. So here's your cysteine, okay? - Yep. - Goes to glutathione. But it's N-acetylcysteine
is the only thing that makes glutathione. That cysteine has to go through this gene and this gene in order
to make your glutathione. So that is not the only thing. So cysteine is the rate limiting step, to synthesize glutathione. That is 100% true. But you also need to have, well look here you need ATP. So all your patients ATP
mitochondria (mumbles). Everybody has ATP, just to what extent. Then there's manganese, magnesium. Oh, look at that. Magnesium. There's an electrolyte. Then glutamate. Most people have sufficient
glutamate anyway. Then, but look at this purple. I know ran backwards for you all, but this is mycotoxins. Mycotoxins and these are all
from published literature. All these little things here. So mycotoxins inhibit this. So if you're giving your patient with mold exposure, or
mycotoxins in their home, N-acetylcysteine and they're
magnesium deficient, okay, and they've got mold,
that N-acetylcysteine ain't gonna do anything. It's just it's a mucolytic. So what's gonna happen is, you're gonna build up their cysteine and the cysteine since
they're having mold, they've got a lot of
oxidative stress going on, that cysteine's gonna go to cystine, make reactive nitrogen species, they're gonna get worse. Then not only that,
but NAC is a mucolytic, and it's gonna dry out
their mucus membranes and they're probably gonna get drier eyes, if they stay on it longer term, they're gonna get possible nose bleeds. Or they might get an enhanced leaky gut, because the mucus membranes in the gut are also harmed. So I love N-acetylcysteine, when there's lung congestion,
or there's nasal congestion and you need to break up mucus membranes, I think it's phenomenal. It is phenomenal. But long term use, makes me very nervous. I had a, I go all in on supplements
(laughs), I used to. I took NAC. I forget how much I took. Maybe just 500 milligrams
a day or something. I don't remember, but I took it everyday. I think I took it everyday for months. Every single day, every
time I took a shower, I got a nose bleed and
my eyes were so dry. They were always dry, I was like, "What the heck? "What is it going on?" Finally, I sussed out what I was taking and I stopped the NAC. The nose bleeds went away. My dry eyes went away. Who knows what I did to my gut. - Yeah, you know I, years ago, when I was sort of
searching for a tagline, what have you, I actually got this from being in practice and I would get through
an incredible intake and have that good clinical acumen and literally, most of the time I would just push my chair back and I would say out loud, "Let's think this through." Right.
- I love that, yeah. - You're such a great, you're exemplary as far as thinking things through, because, I think that's
just how your mind works. It's amazing, because you take the science and put the dots really close together and help us connect them and thinking things through, especially when it
comes to better outcomes in my opinion, tougher and tougher and tougher clinical
cases, in our modern day. Just really, really appreciate it. So I wanna ask you one question and then I wanna roll to the questions that are rolling in on my Slack here. - Okay.
- What about food sources of glutathione? What do you think about that? Are there any? - Yeah, yeah, there are. I saw that question and I
meant to look at my email from Dr. David Quigg, because he goes, "I do the
poor man's glutathione." I was like, "What's that, David?" He goes, "Sprouts, broccoli sprouts." But broccoli sprouts, (laughing)
I'll warn you, they're potent (laughs). They're really potent. So I would definitely
recommend mixing them with other sprouts. - Yeah.
- And then you need to have radish sprouts, to activate whatever that compound, what's that compound in broccoli? It's a crazy long word. - Sulfurophanic gastric, or.
- Thank you, that's it.
- Yep. - Yeah, so and then the radish sprouts, helps activate that. So have your patients grow
broccoli sprouts and radish, but I recommend you do it first and maybe even do it in your clinic and they can try them and the best website that I love for sprouts and I'm a little nervous, because it seems like they're struggling. So your support would be appreciated. I have no affiliation,
I've just been using them for a long time, is Sprout People. So Sprout People.--
- Oh Sprout People. - Yeah, SproutPeople.com. Great website, great tools. Great people. And Dr. David Quigg has
been getting his sprouts from them and growing his own glutathione. Another thing you should know too is.
- Yeah, that's great. - Yeah, is David said that, you know, because Doctor's Data, runs RBC Glutathione Labs. And he says, "Hands down. "Liposomal glutathione
is superior than IV, "for raising the RBC glutathione." He goes, "The RBC glutathione - Okay.
- "Half life of glutathione "is 12 minutes." So when you take liposomal glutathione, you can take it in the morning, you can take it in the afternoon and another thing I should talk about with dosing glutathione, it's better to take a little bit, more often, than a lot at once. - It's better to
- So consistency (mumbles).
- Take a little bit. Yes, because if you have a constant, let's say, you moved to a new home, (sirens blaring)
your patient moved to a new home and they've got particle
board furniture everywhere. New flooring, new carpets. All this stuff, there's
just formaldehyde all over. Glutathione metabolizes formaldehyde, so it's better than taking
say a quarter teaspoon five times a day, rather than
one teaspoon, once a day. Because that glutathione's
just gonna be damaged and all day, they're
breathing 14,000 liters of air and there's a lot of formaldehyde in it. So have them do it throughout the day. - So start low go slow, consistency over intensity for sure. I have to tell you a story
about my radish sprouts. When you say they're potent, they're very potent.
- (laughs) Yeah. - So I was in London this past, late last year, for a medicine conference and I was staying near a Whole Foods and so I was gonna fly out and I don't like to waste anything. So even though I think it was probably against customs, I had these radish
sprouts that I still had. And so I put them in backpack
I flew home with them and the next morning I thought, "Oh I'll just make a juice out of things "that are in the refrigerator." And I put these broccoli
sprouts in my juice. I went to the office with
these broccoli sprouts Vitamexed up in my big juice container and I had a patient that stopped me, in my tracks, in the middle of our session and said, "Did somebody
take a crap in here, "because it smells horrible."
(laughing) Everybody was like, and I'm like, "Oh my gosh." My juice smelled so incredibly bad. - Yeah. - Like I literally almost lost a patient, so.
- Right. - They are profound. - Yeah and be mindful of that too. Because liposomal glutathione
will do the same thing. So, - Yes. - Or similar, not same, similar. It's less potent than those.
- Yeah. I've got a question here
that addresses that. So here we are, from our attendees, how can we rate GSH level in a person with a CBS mutation, particularly
increased enzyme function, as opposed to decreased function? I was found to have very low, excuse me, HCY and high TAU and low GSH. So the basic question, how
can we raise GSH levels in a person with a CBS mutation? - Okay, I have a video on YouTube that talks about if you
google, well if you search in YouTube, CBS, Ben
Lynch, you'll see a video where I talk about the CBS
gene, pretty thoroughly. - It's a great video. - Yeah, the whole thing
about the CBS gene, the snip, there's a lot of misinformation out there. What I will say is, yes a CBS gene can work faster in these 699 variant individuals. But it can also work
faster in the individuals who have lower glutathione. Why, because oxidative stress, speeds up the CBS gene to work. Why would oxidative stress
speed up the CBS gene? Well, because the body wants
to synthesize glutathione. So the speed of CBS is more important and understanding, no the understanding of what
stimulates the CBS gene, i.e. the enzyme, to function, is more important than
looking at what snip is there. So ignore the genetic reports. Look at what is going on and I will show you here. So here's the CBS gene, okay? Purple slows things down
and orange speeds them up. So we have low cysteine,
will speed up the CBS gene. And we have, or sorry. Low homocysteine, yeah, will speed it up. We have hydrogen peroxide
will speed it up. And we have reactive oxygen species will speed it up and
high methylation, SAME, will speed it up and the
co-factor is five and B6. Things that slow it
down, are the opposite. High levels of glutathione. So if you have a fast CBS 699, you would probably want
to consider glutathione. Low reactive oxygen species, also slows it down. So supplementing with things like PQQ, or optimal liposomal
glutathione plus, would help. Low SAME levels. So supporting methylation, but not in excess. Testosterone levels, slow it down. So you know, I don't know
what works with that. I'm not a hormone guy. High cysteine levels,
will also slow it down. So, it's really important to understand what is triggering these genes
to produce these enzymes, rather than just focusing on the snip. That's what dirty genes is all about. That's, I wrote the book,
because there was so much, there is (laughs) so much
misinformation on the internet. I also catered to the
misinformation on the internet, in the beginning and I probably still do. But if I find I'm making
a mistake, I correct it. This whole CBS, I'm gonna
swear, but I'm not (laughs). Is driving me crazy, because there's too much focus on it and you gotta focus on the genetics. - All right, so once again folks, on YouTube, CBS, Ben Lynch. Look it up. A lot more information there. That was a question. I think we already
answered this NAC question. I do have a question,
why does it taste so bad? - Sulfur. Sulfur. Sulfur is nasty. Sulfur stinks. Have you ever been to a hot pool, or any,
- Right out of the ground. - Geothermal hot springs. I went to a town in New
Zealand called Rotorua. And Rotorua is a hot bed
of geothermal activity and you drive, you're
not even in the town yet, and it reeks to high heaven. So it's just the sulfur. - Rotten eggs, all right. Okay, I've been getting
glutathione IV pushes, but I recently heard
that a glutathione drip is better for someone
with heavy metal toxicity, since it enters your
body at a slower rate. Can you comment on this? - (sighs) I don't know about the whole heavy metal connection, because glutathione helps pull metals. I know talking with Dr. Stephen Genuis and Dr. David Quigg and
Dr. Anderson and others, that glutathione pushes are very useful and liposomal balm is very, very useful. What I do know is any time
you put in a substrate, any time you burden an enzyme
with too much of something, it requires work. So, if you're loading someone
up with glutathione fast, they're going to use up more molybdenum. They're going to use up more riboflavin. They're going to use up more
other oxidative things to, to help recycle that. They're gonna use up more selenium. So don't forget, there's
a give and go here. So if you wake up in the
morning at six o'clock and you go for a run. It's different than when you
wake up at six in the morning and you take a shower. The nutrient requirements for
that are totally different. So when you are pushing your patient with a bunch of IV glutathione, you have to make sure
that those co-factors one to process the glutathione, so it can be active with selenium, to recycle it with the riboflavin, to pull out the sulfites
with the molybdenum, to make sure there's magnesium
and electrolytes on board and to make sure that
you don't have too much oxidative stress, it's all important. - Well you've made a couple points in this webinar, about more
is not necessarily better. - Yes.
- Period. - Right.
- And you also made the point about, and you were gonna swear, but you didn't, (laughing)
regarding the crap on the internet, but, I have to tell you, it's really important for us to stay on our toes, because, just yesterday, I saw a patient who thought she might be, even though she knew
nothing about what it meant, under methylating. She was on four different self prescribed combination
methylating substances. - Yes.
- Four different ones. - Yes.
- Stand alone combination ingredients. And methylating, 100%. - And let me say something real quick. I know you wanna honor these questions. It's enough the most
amount of methylfolate that we have in any
supplement, is one milligram. We will not carry a five milligram. We will not carry a 10 or a 15. If you have to go more than
a milligram of methylfolate, something else is wrong. So you have to figure
out what else is wrong. You can't be pushing or
bulldozing your patient, with high amounts of methylfolate. It's dangerous stuff. It's way higher than the RDA. And you might see initial benefits, for a week, a couple months, maybe even a year if
you're lucky, or longer. But any if they're on that high dose, there's something else wrong
that you gotta find it. - Yep. - So it's--
- Because I (mumbles) about a whack a mole game.
(sirens blaring) - Yeah, yeah.
(mumbling) - A lot of fanfare around
here on this webinar. - Yeah.
- All the sirens are out now. Okay, so the body makes an
estimated 10 plus grams, GSH per day, liver alone. How can 400 to 800
milligrams of liposomal GSH, affect feedback inhibition of
GSH synthesis, bio-synthesis? - I don't know. I did not, I was not aware
of 10 grams of glutathione was made a day. - I wasn't either. - Yeah, I don't know. But I do know that just clinical evidence
and personal evidence and seeing my own kids and my family and patients I've worked with, that you give these things and there's it's a bell shaped curve. Remember, it's not just the glutathione. So let's say you give 500
milligrams of glutathione, there's also cysteine and cysteine is the most
plentiful sulfur based compound in the body and that's
a rate limiting step for glutathione synthesis. So if cysteine levels
are becoming elevated, for various reasons, then we're gonna have problems. Individuals with rheumatoid arthritis, have higher levels of cysteine. Why? Well again, if you look
at mechanisms of action, See, so here's your cysteine. In order to get rid of
cysteine by the body, it pees it out, okay? You pee it out. But it's not always that easy. TNF-alpha slows the first gene down, to be able to remove cysteine. So if your patient is inflamed, that cysteine is preventing, is getting slowed significantly from getting peed out of
the body, in the first place and look, how many patients
with autoimmune disease have higher levels of TNF-alpha? A ton. So,
- A ton. - You're gonna get feedback issues, because you're conserving substrate too. So by giving glutathione, your patient is gonna have cysteine sitting around longer, because that cysteine isn't
gonna be going to glutathione, and it's gonna be reacting
inter-reactive nitrogen species. Cysteine is extremely reactive. Homocysteine, we always
hear that being the bad boy, or the bad girl. It's the cysteine. Cysteine is just nasty. - All right, all right. That's a great answer to that question. So what do you recommend for electrolytes? A brand, et cetera? - Well of course I'm gonna be biased, but I'm biased because I've worked in the supplement industry I worked for Biogenesis as a
student rep for a long time. I've been around supplement
industry for a long while and so I best optimal
is Optimal Electrolyte, hands down, by Seeking Health. - Okay. - And we have it in stick packs for travel and we have it in bulk and there's orange, grape and unsweetened. Plain is being changed to the unsweetened. - This does not taste bad. - No, I love it. It tastes like seltzer. - Yeah, okay. So do you have any thoughts
on using glutathione to help sleep? - Yeah. So... Yeah, I would just be careful, about using it in the evening. I would more use the gluta, it's like using adrenal
cortex in the morning with breakfast for patients, to help their sleep at night. So I would be mindful of
giving glutathione at night. I use an aura ring to track and I recommend you use
it for your patients too. But, I don't know if it
would affect my sleep, because I don't take it at night. Because it has phosphocholine in it and phosphocholine can
break down into choline, which makes it building
block back to acetylcholine, which is stimulating for our brains. - No sleep. - But I would say that, yes, it would definitely help with insomnia. It definitely helps with anxiety
and mood disorders, 100%. It's phenomenal stuff, I love it! Just be careful how you use it. - All right. Thinking things through. So, if someone has an MSG allergy, can they take products like
glutamine or glutathione? Are these in the same class? What are the glutamine or
glutathione derive from? - Yeah, so if somebody has, I don't wanna call it an MSG allergy. I would call it a MSG sensitivity. Monosodium glutamate is basically a drug, that's formed to hyper
stimulate the taste buds, or the taste receptors in the brain. So when you go to a restaurant and you're eating foods with MSG in it, it just makes you hyper
aware of the flavor and you love it and so
you consume all of it. So that's why food industries love MSG, because you eat the whole bag, right? - Bring me back more. - Yeah. So if someone is struggling from MSG, then it could be just glutamate and glutamate is metabolized
by a few different genes, but GAD is one. And magnesium and
vitamin B6 are co-factors to help eliminate the
sulfites, is another one. So higher sulfites will
increase glutamate, so it'd be using molybdenum. So if someone with an MSG sensitivity, I would be highly using a
little bit of glutathione, but prior to that, I would be giving electrolytes. Or molybdenum, to knock the sulfites down. But everything that we just talked about. (mumbling)
Optimal liposomal glutathione plus the electrolytes, yeah,
- Okay. - I would say start with those two. - So two more questions here. What's your favorite
lab to test (mumbles), leaky gut, et cetera? - GI Map Diagnostic Solutions. - Okay, GI Map Diagnostics Solutions. Should you be cautious
of giving glutathione when a patient has amalgams? - I've heard that. I don't understand it. - Yep, I was gonna say
- I honestly - the same thing.
- Don't understand it. If somebody has amalgams,
they've got mercury and you need to get it out. The glutathione mobilize
it and get it out. Dr. Stephen Genuis doesn't get it either. I remember Stephen, if you
don't know Dr. Stephen Genuis, you should, Genuis. Somebody asked him
about the color protocol and he was like, "What, I don't know "what you're talking about." So, but Dr. Genuis has been working with environmentally sick patients
for a long, long, long time. Very wise man. - All right, last question here. Is that diagram in your book,
or where can I get a copy? It seems like you reference it quite a bit and it would help me
understand the pathways. - Yes. Look, Einstein, kind of smart dude, right? He said never memorize
anything you can look up. - I take it to heart.
- You can't memorize it. - Everyday (laughs), yes. - So I first started with (mumbles). That was the first gene I read about and I was like, "Okay, I have to start (mumbles) methylfolate." and then I learned B2, that
riboflavin was the co-factor. So I was just giving a bunch of that. People were getting better
and some people weren't, I'm making them worse. Then I realized that, "Oh there's more genes in
the human body besides one." So I started drawing on pieces of paper and connecting them all. Eventually, it turned out to being this. It's called StrateGene. So StrateGene is basically
your patient can run their 23andMe test and their Ancestry test and you can export their
raw data into StrateGene and you get the genetic information, but that's great. That's awesome. But what's most important, are the pathways, okay?
- Yeah. - And at Seeking Health,
we offer the posters. I don't know if you
guys offer the posters. But it may be something to consider. I don't know how you would, it's not a supplement though. - Yep. - But our posters are great, because they're two feet by three feet and they're laminated, so you can draw on them
with dry erase markers and patients love it, because you're with
them and they learn it. I don't have one on the wall yet. I need to mount it. - Well, Dr. Lynch, thank you once again, for your work. Congratulations on
being back in your home. Establishing that routine. I'm gonna be really
excited and happy for you, because I know how important
that is, in general. Thank you for your humility. The way that you dive into this work and you back up and correct and continue to learn more
and take everybody with you. You're always giving back, so it's always such a
pleasure to talk to you. Folks, once again, if you have any questions, we're gonna try to get them answered. From what I could see,
that's all that we had. If there are any more, Ben, I'll make sure that you get them and then also, (upbeat music)
make sure you stay tuned Fullscript, for other
educational, webinars and as well, the winner
of the Dirty Gene book. If you win it, read it. If you don't win it, buy it. All right? All right, thanks so much. - Thanks Holly. (upbeat music)
