Dr Jason Fung’s BRUTALLY Honest Opinion On OZEMPIC!

I've got to talk to you about these um these new injections people are getting to lose weight yeah and the role that they must be playing in our hormone balances what are those bloody things called the gp1s gp1s there's another name for it isn't there yeah uh well it's there's the drug name which is uh OIC is the American name and these are all in a class called gp1s and essentially again very interesting because they essentially really reduce the appetite which goes to show you that and people lose weight like a lot of weight and they keep it off so I people that are using them yeah like a billionaire friend of mine that's very big in a certain industry uses a Zen pick I know Elon Musk came out and said he said he used it yeah asmic as well um I don't I'm not I I I don't have any problem with the OIC because again if you think about it what it's telling you the the lesson it's teaching you about weight loss is that it's not about controlling the calories because the Olympic doesn't burn any calories it's about controlling your hunger it's about that one level deeper why are you taking so many calories so if you simply reduce the hunger you're going to naturally eat fewer calories which is going to cause weight loss and that's what this OIC does it really reduces your appetite to very low levels how it it's it's it's this this hormone called glp1 uh which is a natural sort of hormone it's it's released mostly in the intestines in the distal intestine and the small intestine and in response to certain foods it it goes up right so when you eat the body has a homeostatic mechanism so again remember you know people think that we're just eating machines we eat until you know we explode sort of thing but that's not true when you eat you actually activate the gp1 along with other hormones there's multiple hormonal systems the gp1 is the one we're interested in you activate gp1 which then sets into motion the the the instructions for you to stop eating right so the act of eating sort of sets in motion that whole uh feedback loop to stop right so this is homeostasis which is trying to keep things at a proper level does that mean if you eat slower uh you'll be less you'll eat less there's probably not more time to come out yeah probably it's true um you know although it's probably mostly true that if you eat really really fast that you don't have enough time for the sort of homeostatic mechanisms to kick in so you don't have enough time to stop eating um but the gp1s then go to the brain so they do certain things they help with digestion so they increase insulin response and then they go to the brain it crosses um the the the bloodb brain barrier so the gp1s gets released by the active eating goes into the brain crosses and is active um in the sort of midbrain brain area that tells your body to stop eating what these gp1s do of course is that it's a uh it it gives you the hormone that tells you to stop eating even though you haven't eaten it's sort of that's that's the way the drug works so then what people tell you is that you know they're just not hungry and if they're not hungry then they don't eat and when they don't eat of course insulin Falls and you start to burn calories and lose weight but it wasn't about controlling the calories it was about controlling the hunger that was the important part of it it's the hormones right every successful drug to gain or lose weight right is a hormone it's a hormone based because that's instructions to the body food is energy and food is instructions you change the instructions and you you change the hormone people look at this through an evolutionary lens and say you know we just didn't have this much food so it's the abundance and um ease of access to food it's the fridges that we now have it's the the you know we never had fridges in our home so people point at it and go well that's why people are getting gaining weight and you know we're suffering with obesity at epidemic levels it's just because there's more Supply and the brain is taking advantage of it because once upon a time if we didn't eat that jam and toast then we would have you know maybe not have been able to find food for another two weeks or something yeah I don't think that's the whole story because if you think about it uh and people again um make that assumption that we don't have any control over our body fatness right so they say well it's available so you're going to take it right in fact that's not true because we actually have a number of different uh hormones that tell us to stop eating okay so if you eat you cannot simply keep eating and eating and eating right if you go to an all you can eat buffet at some point you have to stop because you're full right so there are systems very powerful systems within our body that tell us to stop eating so you eat food there are uh stomach stretch receptors for example so as your stomach stretches out it sends a signal to your brain and says stop eating if you eat a lot of protein uh it activates a hormone called peptide YY which tells you to stop eating if you eat a lot of dietary fat you activate a hormone called chosy ainin which again tells you to stop eating these are very powerful if you look in the wild there are no obese Antelope there are no obese Lions why because how much body fat your you carry is actually very important if you are obese as an antelope you're going to get eaten if you are an obese lion you're not going to catch any food so therefore it's going to correct itself so if I overeat now my body will basically overcompensate by burning off the extra calories to it it absolutely so if you eat a huge meal right you eat you know you go to a big wedding or something like that you eat a huge meal the next day you're probably not that hungry if you eat a giant steak so you're activating all these satiety hormones peptide y y chosy ainin you're eating all this food well you may not be hungry for the next day so that means that my body has some kind of Baseline weight yeah it will know whether you should eat more or less so there's a this concept called the sort of body set weight which is a sort of thermometer that is your body sets a weight that you should be at and if you go above that weight or if you eat too much it will activate hormonal systems to bring it back down if you don't eat enough it will also activate hormonal systems to bring it up so it's like a thermostat that you set you have in your room for example you set the the room temperature if it's too hot you're the the room activates the air conditioning if it's too cold it activates the heat your body actually acts the same way if you gain too much body fat your fat cells for example will produce leptin which is another hormone the leptin tells your body to stop eating that's really interesting so in the case of obese people their set point must just be really high yes and that's the Crux of the matter why is that set point being overridden just like if you have a room that's too hot and you look and you say the thermometer is set for room temperature why is it so hot in here then you can say okay well what's the problem and the problem is not you know heat in versus Heat out right that's that's a very simplistic way same thing if your body has too much body fat you got to then think about why are you overcoming the normal compensatory mechanisms that are happening that are stopping you from eating a lot of it relates to processing of foods of course so if you take out so remember I talked about stretch receptors in the stomach right so you eat natural natural foods there's a natural break it stretches the stomach you stop eating well what's one way pull out all the fiber process the foods turn it into say a very fine dust that means it's absorbed extremely quickly into the blood stream so that means that pure you've got Pure carbohydrate basically mainlining it into your I like like an IV your glucose spikes way up your insulin spikes way up completely unnatural right if you eat pure carbohydrate instead of eating it with you know proteins and fats it's going to go it's going to shoot way high that's unnatural and that's going to overcome the natural tendencies for you to stop eating so you know you you've basically overcome that that that that protective mechanism because you've ultr processed the the carbohydrates if you don't eat any protein if you don't eat any fat you're not activating peptide y y which is the satiety hormone you're not activated kyin all of a sudden you're eating you know 500 calories of white bread but you have zero satiety or if you drink a Coca-Cola or a soda for example I've always you know thought about this it's like how can you take a th000 calories for example in one of those giant sodas you get at the ball game or something and don't feel full at all whereas if you took a steak that's 1,000 calories you'd be like I'm pretty full I don't really feel like eating you drink the soda you're like I really feel like eating some chips or popcorn or something why because it has zero satiety interesting so if I'm if I've got a baseball stadium what I want to do is I want to make sure people get a soda because then they'll also buy the chips but if they just eat the chips you know maybe they won't buy anything else but the soda is going to um increase my Revenue because it'll basically he just passed right through them he'll pass right through them they're going to store all that energy as calories but they're going to want more because you haven't made them full right so the the whole point is that you have to think more than about the calories there's more there than just the calorie story there's this whole hormonal balance you're saying that overeating isn't just a choice it's a hormon driven Behavior it's a hormon driven Behavior I mean the whole thing about obesity is is quite interesting to me because if you think about obesity if you think about uh in the United states which is where I get a lot of my data from um you know you have maybe 70% of people overweight or obese and it's going up every year it's been going up every year since 1977 and if you think about that it tells you that the problem is not willpower the problem is not the people the problem is the environment that they find themselves in the food environment that they find themselves in because you can take an analogy say you have hundred children one of them fails well that might be the child they didn't study what if 70 of them fail would you say it's it's each and every one of them's fault or would you say it's more likely that it's the teacher's fault I think it's more likely that it's the teacher's fault so if we have a 100 Americans and 70 of them are obese the problem is likely not an individual willpower problem the problem is likely that there's something wrong with the message we're giving people the information we're giving people and the food environment that we're finding ourselves in which is dominated by this sort of calories in calories out thinking and what's really unfair of course is that we put the blame on the Obesity or overweight on the individual and we say well they let themselves go and they didn't watch themselves they weren't careful it's their fault and that's the stigma that comes with this whole calories in calories out thinking because we say it's their fault because they could choose what they eat it's like yes they could choose what they eat but they didn't choose the food environment that is telling them to eat all this ultr processed food that is making all this ultr processed food available to them that is telling them that all this Ultra processed food is good for you if you love the divver CEO brand and you watch this Channel please do me a huge favor become part of the 15% of the viewers on this channel that have hit the Subscribe button it helps us tremendously and the bigger the channel 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Channel: The Diary Of A CEO Clips

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Id: raKfaFKH3SY

Length: 12min 33sec (753 seconds)

Published: Tue Jan 23 2024