all this is Dr mobin Sayad from Dr bean.com welcome to one more show so the discussion today is very interesting the uh one of the important line in this study that I'm going to present today it says women who drink eight or more alcoholic beverages per week have significantly more likely to to have coronary heart disease compared to those who are drinking or who drink less this is a fascinating study from Kaiser Permanente uh by the the lead author is Dr Jamal Asana full disclosure he is a friend as well the study is done on the Kaiser Permanente participants because Kaiser has been asking individuals for their um the their drinking status if they drink or not and if they do drink how much do they drink on daily basis and then Kaiser was able to follow those individuals and kind of understand what is the relationship of drinking and coronary heart disease and it is interesting fascinating that women were actually more at risk compared to men and the women that were drinking more were more at risk compared to those that were drinking less so that is a Okay so hereit are my network briefly disconnected I will edit out these disconnections afterwards this is happening since morning today okay so here is a study the study is not published yet there is no preprint available there are few articles and the study was presented in the American cardiac Association as well so we'll look into that so here American College of Cardiology it is a um article in there alcohol raises heart disease risk particularly among among women then in Kaiser Permanente they say modest amount of alcohol tied to increase hard disk disease risk especially in women so let me very quickly show you the links so of course this is Dr bean.com if you would like to have more lectures please go to Dr bean.com and become a member there uh here is the Kaiser's U article modest amounts of alcohol tied to increase heart disease risk especially in women kaer permanent study suggest just two drinks a day can increase the risk of heart disease women who reported drinking eight or more alcoholic beverages per week were significantly more likely to develop coronary heart disease than those who drank less so it is a fascinating article to read and then here American College of Cardiology alcohol raises heart disease risk particularly among women the lead author is Dr Jamal Rana MD PhD he's a cardiologist and he is also an adjunct um researcher with the Kaiser permanent is division of research adjunct investigator so let's look at this study with my drawings as usual so here are the properties of the study it is conducted in Kaiser permanent in Northern California individuals 18 to 65 years of age average 44 years so relatively young population who did not have the history of heart disease or stroke I believe there were 430,000 265 total individuals that were participant in it data was collected from the alcohol as Vital sign initiative in 2014 to 2015 this is amazing and I know that Kaiser asked these questions so they use alcohol uh you know usage and and the levels of it as a Vital sign as well just like they would take your heart rate and temperature and other signs here alcohol as a Vital sign initiative they had it in 2014 and 2015 so the participants who were providing this data then they followed those participants for four years afterwards to see what was the prevalence of diagnosis of coronary disease so women there were 189,000 women there were 243,000 men that were participating in it in the following 4 years there were 3,18 individuals who were diagnosed with the coronary disease or heart disease so here this was I think very interesting from Dr Jamal Rana he said there has long been this idea that alcohol is good for the heart but we are seeing growing evidence challenging that notion said lead author Jamal Asana mdphd a cardiologist with the permanent medical Medical Group and an adjunct investigator at the Kaiser Permanente division of research so check this out he says we felt it was important to leverage comprehensive data we have available at Kaiser Permanente to contribute to this conversation by exploring the relationship between levels of alcohol use including happy heavy episodic or bch drinking and the risk of coronary heart disease in women and men so they actually were doing it for both although the the results for women are more surprising for me these were even shocking so this study was funded by the National Institute on alcohol abuse and alcoholism co-authors were Felicia WJ mph of the division of research and isaaca MD mph metstar Union Memorial hospital now here is what they did they classified the drinking habit according to the federal classification so that was one or two drinks per week as low intake then from three to seven drinks as moderate intake for women 3 to 14 was moderate for men men weekly so here check this out that this was lesser number of drinks per week for women even then the likelihood or the risk you would see will be more in women so 3 to 7 for women in moderate in high intake 8 plus for women 15 plus beverages alcoholic beverages per week for men and binge drinking is defined as four plus for men three plus beverages for women on a daily basis at least in the past 3 months so that will be binge so they were comparing this level of intake to each other and let's see what they were finding so they found that women who were averages per week so that is high intake had 33% to 51% higher risk of developing coronary disease compared to those women who were drinking lesser than eight beverages alcoholic beverages per week 33% to 51% higher risk or higher likelihood of developing coronary disease then here this is moderate to binge so binge as we said before 3 plus alcoholic beverages on daily basis for at least last 3 months so women who were taking three plus alcoholic beverages daily for at least last three months when they were compared to those women that were taking three to seven beverages per week moderate amount of intake the binge drinking women had 68% higher likelihood of developing coronary disease now for men there was also a difference so here the same thing binge drinking men 3 plus or four plus actually per day and for at least 90 days so this three plus should be four plus so these men the binge drinking men when compared to moderate intake uh individuals men 33% higher likelihood of developing cardiac events or coronary heart disease if you look at the women this is 68% it is significant 68% highly High likelihood of developing corri disease so Stacy a sterling who is one of the senior authors in this research scientist Kaiser prominent division of research she says alcohol has been shown to raise blood pressure and lead to metabolic changes that are associated with inflammation and obesity so number one increase blood pressure and number two inflammation and number three obesity now blood pressure when that is increased of course that puts a pressure that puts a stress on the heart because the blood vessels are now now constricted and it is difficult for heart to pump the blood in them the resistance has increased which which then causes stress on the heart which can then lead to uh potentially to coronary disease similarly inflammation we have been talking about inflammation and cardiovascular system health for a long time and obesity of course is a link as well so alcohol kind of promotes these and that would result in incre increased risk of the heart disease women also process alcohol differently than men due to biologic and physiological differences and this may contribute to the increased heart disease so that is a very important thing to notice and I think my network kind of died for another second here so let me just repeat this part it's concerning because there has been an increasing prevalence of alcohol use among young and middleaged women including in the number of women who binge drink so that is a scary thing that is a concerning thing that younger women number one they are using more alcohol and then middle-aged women younger and middle-age both including the number of women that are be drinking so Dr Rana says our findings suggest that as doctors we need to be doing more to talk to our patients especially our female patients about the potential heart risk associated with excess and Bening drinking so that is the discussion just very quickly uh this is the study here as well I would request you to take a look U binge drinking the highest risk was Seine in women and men who reported heavy episodic or binge drinking women in this category were 68% more likely to to develop heart disease compared to those women reporting moderate intake so we we discussed that then look at this one overall 3,18 study participants were diagnosed with coronary heart disease during the 4-year followup period among women those who reported high alcohol intake had a 45% higher risk of heart disease than those reporting low intake and a 29% higher risk than those who report who reported moderate intake the study did not include people who said they did not drink alcohol so fascinating study thank you very much for listening in this is the talk for today uh please like subscribe and share and I would see you tomorrow at the same time if you would like to have good medical lectures then go to Dr ban.com and get access there as well the links are in the description thank you very much and I'll see you tomorrow bye for now
