[*MUSIC STARTS PLAYING*] AN ATHLETE SQUATTED
500 REPS IN 20 MINUTES. THIS IS WHAT HAPPENED TO HIS KIDNEYS. KG IS A 21 YEAR OLD MAN, PRESENTING TO THE
EMERGENCY ROOM, UNCONSCIOUS. PARAMEDICS TELL THE ADMITTING NURSE THAT HE
HAD AT LEAST 2 SEIZURES IN THE LAST 15 MINUTES. KG WAS A COLLEGE ATHLETE. BEFORE THE SUMMER TO HIS JUNIOR YEAR, HE HAD
FALLEN BEHIND. KG BROKE UP WITH HIS LONGTIME GIRLFRIEND AND
BECAME DEPRESSED. FOR SEVERAL MONTHS, HE LIMITED HIS TRAINING
BECAUSE HE DIDN’T WANT TO DO ANYTHING. WHEN THINGS CLEARED UP, KG NEEDED TO CATCH
UP WITH HIS TEAMMATES ON HIS PRESEASON CONDITIONING. HE STARTED MAXING OUT HIS WORKOUTS, EVERYDAY. HE DID SEVERAL DRILLS EARLY IN THE MORNING. HE CAME BACK LATER THAT DAY TO DO SPRINTS ON A BIKE. THE NEXT MORNING, MORE DRILLS. THEN ABS FOR 2 HOURS AT NIGHT. HE MOVED ON TO 150 REPS EACH OF BENCH PRESS,
PULL UPS, AND SQUATS. HE DIDN’T CARE HOW MANY SETS IT WOULD TAKE,
AS LONG AS HE COULD WORK IN ALL THE REPS. AS WEEKS PASSED, KG BUILT HIMSELF UP TO 3
WORKOUTS DAILY, EACH ONE AT MAXIMUM INTENSITY. AND HE MADE HIS WAY UP TO 500 REPS FOR EACH
LIFT. ONE DAY, KG’S TEAMMATES FELT SOMETHING WRONG. BEFORE TRAINING STARTED, HE COMPLAINED THAT
HIS URINE WAS RED. DURING THIS WORKOUT, HE WOULDN’T GO LOW
ENOUGH ON HIS SQUATS. HIS VISION WOULD DARKEN HALFWAY THROUGH EACH SET. ON HIS 500TH REP OF SQUAT, KG STRUGGLED. AND THEN, HE COLLAPSED. TEAMMATES THOUGHT HE WAS JOKING, UNTIL HE
STARTED SHAKING UNCONTROLLABLY. COACHES CALLED FOR AN AMBULANCE. KG REGAINED CONSCIOUSNESS. BUT PARAMEDICS SAW HIM BECOME UNRESPONSIVE
AGAIN AS HE ARRIVES TO THE EMERGENCY ROOM WHERE WE ARE NOW. GIVEN THIS HISTORY OF PRESENT ILLNESS, THERE’S
A FEW CLUES AS TO WHAT’S HAPPENING. DURING EXERCISE, THE BODY NEEDS WATER AND
OXYGEN TO KEEP UP WITH THE EXTRA ENERGY DEMAND. KG’S 500 REPS OF SQUAT WAS PROBABLY PUSHING
THINGS TOO HARD BECAUSE PARTS OF HIS MUSCLES WERE FOUND IN HIS URINE, MEANING HE HAS RHABDOMYOLYSIS. RHABDO MEANING STRIPED, REFERRING TO THE LOOK
OF SKELETAL MUSCLE. AND LYSIS MEANING A BREAKING DOWN OF. AN EXTREME BREAKDOWN OF SKELETAL MUSCLE AS
THE TISSUE LEAKS ITS REMAINS INTO HIS BLOODSTREAM. THE KIDNEYS ARE SUPPOSED TO FILTER BLOOD. BUT THEY’RE NOT SUPPOSED TO FILTER MUSCLE
PROTEIN. HIS KIDNEYS ARE GOING TO BECOME PERMANENTLY
DAMAGED. THIS CAN HAPPEN TO ANYONE WHO PUSHES THEIR
WORKOUTS TOO HARD, BUT FOR KG, THIS LOOKS LIKE IT’S HAPPENING ON TOP OF SOMETHING
ELSE. KG MENTIONED TO HIS TEAMMATES THAT HIS URINE
HAD BECOME RED, EARLIER THAT DAY. ANOTHER URINE SAMPLE FOUND HEMATURIA. BLOOD PRESENCE IN URINE, COMING FROM ONLY
HIS LEFT KIDNEY. IN HUMANS, THE LEFT KIDNEY IS BIGGER THAN
THE RIGHT AND THE ARTERY THAT FLOWS BLOOD IN TO THE LEFT KIDNEY IS SHORTER THAN THE
ARTERY THAT FLOWS IN TO THE RIGHT. BECAUSE A SHORTER ARTERY MEANS LESS RESISTANCE
TO FLOW, MORE BLOOD NATURALLY GOES TO THE LEFT. KIDNEY STONES OR AN INFECTION CAN CAUSE ONE-SIDED
HEMATURIA, BUT KG DOESN’T HAVE EITHER ONE OF THOSE, SO SOMETHING ELSE IS CAUSING THIS. HIS RIGHT KIDNEY IS FINE, FOR NOW. DOCTORS READ MORE IN TO KG’S MEDICAL RECORD
AND FIND THAT HE HAS SICKLE CELL TRAIT. TRAIT, NOT DISEASE. AND THIS EXPLAINS EVERYTHING. SICKLE CELL IN GENERAL IS WHEN THE RED BLOOD
CELLS BECOME SICKLE SHAPED. NORMALLY, RED BLOOD CELLS ARE AN OVAL, SMOOTH
SHAPE. WHEN RED BLOOD CELLS SICKLE, THEY BECOME SHARP,
THEY DRAG ON BLOOD VESSEL WALLS, THEY CLUMP TOGETHER, AND THEY BLOCK BLOOD FLOW, WHICH
CAUSES PROBLEMS. BUT, THEY’RE NOT GOING TO SICKLE BY THEMSELVES
FOR NO REASON THOUGH. THEY DO IT BECAUSE SOMETHING IS WRONG WITH
THEIR HEMOGLOBIN, WHICH IS THE PROTEIN INSIDE THAT CARRIES OXYGEN. PROTEINS ARE MADE FROM GENES IN YOUR DNA. GENES COME IN PAIRS. SICKLE CELL DISEASE MEANS BOTH HEMOGLOBIN
GENES IN THAT PERSON ARE MUTATED. [DR. PAVLOS MSAOUEL] IF BOTH COPIES OF THE GENE
ARE CHANGED, THEN THE CELLS WILL LOOK LIKE SICKLES EVERYWHERE. MOST OF THE INDIVIDUALS WHO HAVE SICKLE CELL
ARE OF AFRICAN ANCESTRY. THERE CAN BE PEOPLE OF LATINO ANCESTRY AND
CAUCASIANS AS WELL, BUT THE VAST MAJORITY ARE BLACKS. AND WHY DID IT DEVELOP? IT HAPPENED BECAUSE IF YOU HAVE THE SICKLE
CELL TRAIT, IT CAN PROTECT YOU FROM MALARIA. [DR. BERNARD] WHICH IS AN INFECTION THAT TARGETS
RED BLOOD CELLS. IN A PERSON WITH SICKLE CELL TRAIT, ONLY 1
GENE IS SICKLE AND THE OTHER GENE IS NORMAL. RED BLOOD CELLS IN SICKLE CELL TRAIT DON’T
SICKLE UNLESS THE CONDITIONS ARE RIGHT. AND IN KG, THOSE CONDITIONS WERE RIGHT. IF BLOOD HAS WATER, AND RED BLOOD CELLS HOLD
OXYGEN, BUT KG HAS A GENETIC ABNORMALITY THAT AFFECTS THE PROTEIN THAT CARRIES THAT OXYGEN,
THEN SICKLE CELL TRAIT EXPLAINS WHY HIS MUSCLES ARE DYING, AND WHY HE HAS HEMATURIA. THE KIDNEYS FILTER BLOOD TO PRODUCE URINE. A BETTER WAY TO LOOK AT THIS, IS THAT THE
KIDNEYS REABSORB WATER, AND THE REST BECOMES URINE. BUT HOW DO THEY DO THIS? IN A SMALL SCIENCE EXPERIMENT, SALTY WATER
IS PLACED IN A TUBE. THE TUBE IS SUBMERGED IN A POOL OF DISTILLED
WATER. YOU WILL SEE THAT WATER FLOWS IN TO THE TUBE. THAT WATER FLOWS TOWARDS WHERE THERE’S SALT. IN THE KIDNEY, FILTERED BLOOD GOES IN TO THE
MEDULLA. THIS ENVIRONMENT IS “SALTY” AND LOW IN
OXYGEN. BECAUSE WATER FLOWS TOWARDS WHERE THERE’S
SALT, THE KIDNEYS USE THIS SALTY MEDULLA, TO GET WATER TO FLOW IN SO IT CAN BE REABSORBED. DURING EXERCISE, YOU WANT THIS TO HAPPEN SO
YOUR BODY CAN HAVE AS MUCH WATER AVAILABLE AS POSSIBLE. WHAT DOESN’T GET REABSORBED, IS WHAT BECOMES
URINE. WHEN WATER FLOWS TOWARDS SALT, THAT SALTY
REGION BECOMES DILUTE. SO AS MORE WATER GETS REABSORBED, THE KIDNEY
MEDULLA BECOMES LESS SALTY. THIS IS NATURAL. THE CELLS HERE [ASCENDING LIMB] ARE DESIGNED
TO FIGHT THIS AND PUMP IN MORE SALT. THIS MAINTAINS THE SALTINESS AND MAKES SURE
THAT WATER CAN CONTINUE TO FLOW IN TO THE MEDULLA TO GET REABSORBED. BUT WHEN SOMETHING IS PUMPED IN, YOU NEED
ENERGY TO DO THAT PUMPING. WHEN SOMETHING NEEDS ENERGY, IT NEEDS OXYGEN
TO MAKE THAT ENERGY, AND THIS IS WHERE KG’S PROBLEM HAPPENS. THE MEDULLA ALREADY HAS LOW OXYGEN BECAUSE
THAT HELPS IT STAY SALTY. KG HAS SICKLE CELL TRAIT, MEANING HIS RED
BLOOD CELLS HAVE A MUTATED FORM OF HEMOGLOBIN, WHICH IS THE PROTEIN THAT CARRIES OXYGEN. THIS MEANS THE RED BLOOD CELLS GOING IN THE
MEDULLA ARE GOING TO SICKLE THERE BECAUSE OF THAT LOW OXYGEN. THEY CLUMP TOGETHER AND CAUSE A BLOCKADE,
MEANING THE MEDULLA DOESN’T GET ANY OXYGEN AT ALL. NO SALT IS PUMPED BACK IN TO THE MEDULLA. AS WATER KEEPS FLOWING IN, THE MEDULLA BECOMES
LESS SALTY. WHEN IT’S LESS SALTY, LESS WATER FLOWS IN
TO IT, SO THEN WATER ISN’T REABSORBED. AND EVERYTHING BECOMES URINE, CAUSING KG TO
LOSE A LOT OF WATER. [DR. MSAOUEL] INDIVIDUALS WHO HAVE SICKLE CELL
DISEASE OR SICKLE CELL TRAIT, BECAUSE OF THE SICKLING, THE MEDULLA WILL BE DAMAGED. AND ITS ABILITY TO BE SALTY WILL BE COMPROMISED. BECAUSE OF THAT, EVENTUALLY THE KIDNEYS WILL
NOT BE ABLE TO CONCENTRATE URINE ENOUGH. [DR. BERNARD] LOSING WATER MEANS KG’S BLOOD IS
THICKER THAN NORMAL. THINK OF IT LIKE THIS MOLASSES. IT’S HARDER FOR BLOOD TO FLOW, CAUSING HIS
OVERWORKED MUSCLES TO BECOME STARVED OF OXYGEN, AS THEY MAKE MORE LACTIC ACID AS HE KEEPS
SQUATTING. THIS ACID, CAUSES MORE OF KG’S RED BLOOD
CELLS TO SICKLE, WORSENING THIS ENTIRE CYCLE. IF HIS PROBLEMS ARE COMING FROM LOSING WATER,
THEN REPLACING THAT WATER IS THE FIRST STEP IN TREATING HIM. IV FLUIDS ARE IMMEDIATELY STARTED. THIS WILL HELP PUSH MORE WATER THROUGH HIS
KIDNEYS AND HELP MINIMIZE SOME OF THE PERMANENT KIDNEY DAMAGE. KG IS CONSCIOUS AGAIN. HE COMPLAINS TO DOCTORS OF SHARP MUSCLE ACHES. ANYONE WHO SQUATS 500 REPS IS GOING TO HAVE
SORE LEGS. BUT THE MEDICAL TEAM CALLS IN A SURGEON BECAUSE
KG’S LEGS ARE STARTING TO SWELL WITH FLUID. BECAUSE PARTS OF HIS MUSCLES WERE DISSOLVING
AWAY, THEY RELEASED PROTEINS AND CELLULAR MATERIAL. THE IMMUNE SYSTEM DETECTS THIS. IT THINKS THE BODY HAS BEEN INFECTED, CAUSING
THE AREA TO START TO SWELL WITH FLUID. USUALLY THIS IS OK, EXCEPT THE MUSCLES ARE
COVERED BY A CONNECTIVE TISSUE. IN THE LEGS, THIS TISSUE IS UNYIELDING, SO
PRESSURE BUILDS UP IN KG’S LEG MUSCLES WITHOUT GIVING WAY. IF NOTHING IS DONE, HIS LEGS WILL SWIM IN
A POOL OF TOXIC LIQUEFIED MUSCLE [COMPARTMENT SYNDROME]. SURGERY NEEDS TO HAPPEN IN THE NEXT FEW MINUTES,
BECAUSE IF IT DOESN’T, KG’S LEGS WILL NEED TO BE SEPARATED FROM HIS BODY, TO KEEP
HIM ALIVE. SURGEONS OPERATE, TO IMMEDIATELY RELIEVE THIS
PRESSURE. AND IT’S DONE WITH NO COMPLICATIONS. BUT KG’S RHABDOMYOLYSIS KEEPS WORSENING. AS THE WEEKS PASS, HE GETS BETTER. HE’S HYDRATED. HIS KIDNEYS WERE DAMAGED, BUT THEY’RE STILL
WORKING, SOMEWHAT. AT 25 DAYS AFTER PRESENTING TO THE EMERGENCY
ROOM, KG IS DISCHARGED WITH ADVICE TO COOL IT ON THE EXERCISE INTENSITY. IT IS GOOD TO EXERCISE, BUT IT’S NOT GOOD
SQUAT 500 REPS FOR NO GOOD REASON. HE CAN’T PLAY ANY GAMES WITH HIS TEAM, BECAUSE
HE NEEDS PHYSICAL THERAPY AFTER HIS SURGERY. RECOVERY IS GOOD AND EVERYTHING SEEMS TO BE
HEALTHY IN HIS LIFE. BUT 18 MONTHS LATER, KG PRESENTS AGAIN TO
THE EMERGENCY ROOM. THIS TIME WITH FEVER, HEMATURIA AGAIN, AND
A SHARP PAIN IN HIS RIGHT SIDE. HE TELLS THE MEDICAL TEAM THAT OVER THE LAST
FEW WEEKS, HE HAD BECOME SHORT OF BREATH. HE TELLS DOCTORS THAT HE HADN’T DONE ANY
HIGH INTENSITY WORKOUTS, HE HADN’T EVEN SQUATTED SINCE THE LAST TIME HE WAS IN THE
HOSPITAL. A CHEST XRAY [MEDIASTINAL WIDENING] SHOWS
A WIDENING IN HIS CHEST. THIS COULD MEAN THAT HE HAS A PROBLEM IN HIS
HEART OR LUNGS, OR THAT A CANCER HAS SPREAD TO HIS CHEST. A CT SCAN ON KG’S ABDOMEN FINDS A TUMOR
IN HIS RIGHT KIDNEY, BRINGING US BACK TO SICKLE CELL TRAIT. [DR. MSAOUEL] WHEN SOMEBODY HAS SICKLE CELL TRAIT. THEY’RE NOT SUPPOSED TO HAVE HEMATURIA. IF SOMEONE DEVELOPS BLOOD IN THE URINE. AND THEY’RE YOUNG. AND THEY’RE OF AFRICAN AMERICAN DESCENT
AND THEY KNOW THEY HAVE SICKLE CELL TRAIT, THEN IT IS A GOOD IDEA TO AT LEAST DO AN ULTRASOUND
OF THEIR KIDNEYS. AND IF A MASS OR SOMETHING THAT LOOKS LIKE
A MASS IS FOUND, THEN THAT SHOULD BE TAKEN VERY SERIOUSLY. [DR. BERNARD] WE KNOW THAT THE KIDNEY MEDULLA IS
SALTY, AND IT HAS LOW OXYGEN. WHEN SOMETHING IS SALTY, CELLS IN THAT AREA
WILL HAVE 2 PROBLEMS. FIRST, A LOT OF THE DNA IS GOING TO BE BROKEN
BECAUSE OF THE HIGH SODIUM. AND SECOND, THOSE BREAKS AREN’T REPAIRED
BECAUSE OF THAT HIGH SODIUM. BOTH OF THESE ARE NORMAL. IT’S HAPPENING EVERY SECOND IN HEALTHY HUMANS. DNA REPAIR IS USUALLY RESTORED WHEN KIDNEY
MEDULLA CELLS RETURN TO A NORMAL ENVIRONMENT. BUT FOR KG, HE DOESN’T HAVE A NORMAL ENVIRONMENT. HIS BLOOD CELLS SICKLE IN THE MEDULLA BECAUSE
OF SICKLE CELL TRAIT. THIS BLOCKS BLOOD FLOW IN, SO THERE’S LESS
OXYGEN AND LESS ENERGY FOR CELLS TO KEEP THE MEDULLA SALTY. DO YOU REMEMBER THAT THE ARTERY GOING IN TO
THE RIGHT KIDNEY IS LONGER THAN THE ONE GOING IN TO THE LEFT? WELL THIS MEANS LESS BLOOD FLOWS IN TO THE
RIGHT COMPARED TO THE LEFT. THIS MEANS A LOT LESS OXYGEN GOES TO THE RIGHT,
SO THE MEDULLA THERE IS NOT SALTY AT ALL. WHEN THERE IS NO SALT AND NO OXYGEN IN A PLACE
THAT SHOULD BE SALTY WITH SOME OXYGEN, IT LOOKS LIKE BACKUP DNA REPAIR, NOT THE NORMAL
REPAIR, IS ACTIVATED EARLY. ANY REPAIR SHOULD BE GOOD, BUT IN THIS CASE,
IT ISN’T. BECAUSE THE HUMAN GENOME HAS NATURAL FLAWS. 30% OF OUR GENOME REPEAT CODE. WHEN THESE REPEATS ARE PALINDROMIC, MEANING
THEY ARE THE SAME FORWARDS AS THEY ARE BACKWARDS, NORMAL REPAIR PATHWAYS HERE CAN HAVE A LITTLE
TROUBLE FIXING THINGS. THIS MEANS THAT BACKUP PATHWAYS WILL HAVE
A LOT OF TROUBLE FIXING THINGS. [DR. MSAOUEL] WHEN YOU HAVE TOO MANY AREAS THEN
THE MECHANISMS THAT MAY TRY TO REPAIR ANY DAMAGE IN THOSE AREAS, MAY GET TOO CONFUSED. BECAUSE THEY MAY NOT BE ABLE TO UNDERSTAND
“WHERE DID THIS NAME START FROM?” WAS IT FROM THE LEFT TO THE RIGHT? OR THE RIGHT TO THE LEFT? AND BECAUSE OF THAT, THOSE AREAS MAY BE MORE
LIKELY TO BE REPAIRED IN THE WRONG WAY. HENCE WHY, THOSE AREAS ARE THE ONES WHERE
YOU CAN FIND THOSE MUTATIONS THAT CAN LEAD TO CANCER. [DR. BERNARD] TODAY, WE KNOW A LOT OF THESE PALINDROMIC
REPEATS HAPPEN ON CHROMOSOME 22. DELETIONS HERE ARE THE MOST COMMON CAUSE OF
BIRTH DEFECTS. LEUKEMIA ALSO COMES FROM HERE WHEN THINGS
ARE SHIFTED AROUND FROM A DIFFERENT CHROMOSOME. AND NEXT TO THE LEUKEMIA GENE, IS THE ONE
THAT WAS AFFECTED IN KG’S RIGHT KIDNEY. SAMPLES OF THE TUMOR CELLS WERE TESTED. A PROTEIN THAT HELPS REGULATE HOW QUICKLY
A CELL REPRODUCES, WAS MISSING. THIS MEANS THE CELL WITH THIS GENETIC DEFECT,
DOESN’T STOP REPRODUCING. IT GROWS INTO A TUMOR IN THE KIDNEY MEDULLA,
BECOMING THE CANCER KNOWN AS RENAL MEDULLARY CARCINOMA. [DR. MSAOUEL] RMC IS ESSENTIALLY WHAT WE CALL RENAL
MEDULLARY CARCINOMA. IT IS PROBABLY THE MOST DEADLY KIDNEY CANCER. IT HAPPENS ALMOST ALWAYS IN PEOPLE WHO HAVE
EITHER SICKLE CELL TRAIT OR SICKLE CELL DISEASE. IN THE VAST MAJORITY OF CASES, UNFORTUNATELY,
IT WILL PRESENT AS WHAT WE CALL STAGE 4, MEANING IT WILL HAVE SPREAD TO DIFFERENT ORGANS BY
THE TIME WE DIAGNOSE IT. [DR. BERNARD] SAMPLES OF THE LYMPH NODES BY HIS
HEART, TEST POSITIVE FOR THE SAME CANCER CELLS FOUND IN HIS KIDNEY, MEANING THE TUMOR HAS
SPREAD TO DISTANT SITES OF KG’S BODY. IT’S IN HIS LUNGS NOW, CAUSING HIS SHORTNESS
OF BREATH. AND IT’S ON HIS LIVER. [DR. MSAOUEL] IF IT IS NOT TREATED VERY FAST, THEN
IT CAN TAKE SOMEONE’S LIFE WITHIN 3 MONTHS OF DIAGNOSIS. IT IS POSSIBLE THAT THIS VERY INTENSE EXERCISE
REGIMENT WHICH LED TO ALL THE OTHER ISSUES, MAY HAVE ALSO INCREASED THE RISK OF DAMAGING
THE MEDULLA IN A WAY THAT CAN CAUSE RMC. [DR. BERNARD] BUT NO MATTER WHAT, SQUATTING 500
REPS SUDDENLY, CAN CAUSE ANYONE’S MUSCLES TO DIE. ADD SICKLE CELL TRAIT, AND THE RHABDOMYOLYSIS
WILL BE MUCH MORE INTENSE, AND WILL DAMAGE THE KIDNEYS. [DR. MSAOUEL] SOME OF THE INDIVIDUALS WHO ARE DIAGNOSED
WITH STAGE 4 RMC, AND THAT WE HAVE TREATED THAT HAVE LIVED FOR MORE THAN 5, 6, OR EVEN MORE THAN 7 YEARS
AND THEY ARE DISEASE FREE. WHAT WE WOULD LOVE TO DO, IS TO ACHIEVE THAT
FOR EVERYBODY. AND HOPEFULLY ONE DAY, WE WILL. [DR. BERNARD] BEFORE THERAPY WAS STARTED, A BLOOD
CLOT SUDDENLY LODGED INTO KG’S LUNGS. HIS HEART STOPPED BEATING. WHEN SOMEONE HAS ADVANCED CANCER, THEIR CHANCES
OF DEVELOPING BLOOD CLOTS ARE SEVERAL TIMES HIGHER THAN IF THEY DIDN’T HAVE CANCER. SICKLE CELL TRAIT CAN SOMETIMES BE DOWNPLAYED
AS “BENIGN,” BECAUSE IT ISN’T SICKLE CELL DISEASE. BUT IT’S NOT TOO HARD TO PUT THE BODY IN
A SITUATION WHERE THE SICKLING CAN HAPPEN. [DR. MSAOUEL] MOST PEOPLE WHO HAVE SICKLE CELL
TRAIT NEVER ACTUALLY DEVELOP ANY PROBLEMS. SO YOU CAN HAVE THE SICKLE CELL TRAIT AND
LIVE A VERY NORMAL LIFE WITH NO ISSUES. HOWEVER, IF YOU HAVE THE SICKLE CELL TRAIT,
YOU ARE AT RISK OF CERTAIN COMPLICATIONS IF YOU ARE TAKING EXERCISE TO AN EXTREME. EVERYTHING SHOULD BE DONE IN MODERATION. [DR. BERNARD] FOR ATHLETES, SICKLE CELL TRAIT DOESN’T
MEAN YOU CAN’T PLAY. IT SHOULDN’T EVER EXCLUDE ANYONE. BUT PEOPLE NEED TO KNOW THAT SICKLE CELL TRAIT
IS NOT BENIGN. FOR KG, HE COULDN’T BE RESUSCITATED. HE PASSED WITH ALL FAMILY PRESENT. FOR ATHLETES WHO DO HAVE SICKLE CELL TRAIT,
STAY WELL HYDRATED. TAKE BREAKS DURING TRAINING, EXTRA BREAKS
WHEN IT’S HOT OUTSIDE. IF ANYTHING DOESN’T FEEL RIGHT, STOP WHAT
YOU’RE DOING AND TELL SOMEONE IMMEDIATELY. BECAUSE NEXT TIME, AWARENESS OF SICKLE CELL
TRAIT CAN SAVE A LIFE FOR SOMEONE LIKE KG. THANK YOU FOR WATCHING. TAKE CARE OF YOURSELF. AND BE WELL.
Same!
Very interesting. Sad that the guy passed so fucking unfortunate.
The comparison with Goggins and a guy who died from cancer is unbecoming though dude. Just my two cents.