Aging Research: Is There a Longevity Gene?

since we are here in this family let me tell you my a short abstract of what I'm going to talk about so that you can decide if you want to stay or there's a great cafe here I hear it's really a story about this a Jewish guy that goes into a life insurance office and says I'd like to have a life insurance and the clerk looks in England says excuse me how old are you and he says I'm hundred years old and the clerk says you're kidding we're not giving life insurance to 100 years old and he said no that's not true my mother is insured here so he said how old is your mother she's hundred and twenty and he's she okay yeah she's okay so let me actually pause for a second a CNN today just before I left I saw that the oldest person in the world died today at hundred and sixteen by the way the oldest person in the world used to be 122 and they're getting younger which we can talk about it 116 is not so impressive but anyhow she is she died so his mother is 120 and she's doing fine so the clerk goes to the boss and they said you know this is a good Public Relation why don't we just give him and so they said listen why don't you come on Tuesday and we'll have everything ready for you to sign and he said you know I'm sorry I'm busy on Tuesday so they look at him 100 years old what are you doing Tuesday said it happens that in Tuesday my grandfather is getting married your grandfather is getting married how old is your grandfather said 150 115 he wants to get married he said he doesn't want to but his parents puts lots of pressure okay lots of problems with this this story among them it's just a story but it gives you kind of an introduction to my world okay and I'll try to be more scientific from now on a so a and I you know I called it my recipe for the future or my recipe for ageing and that's kind of what we are trying to achieve we're trying to really have a strategy to delay aging and age-related diseases our focus is good quality of life without diseases and not not necessarily longevity but but I'll tell you how longevity plays a role here and I'll also make a comment at the end about Moses okay so I'm going to ask you several questions by the way I'm planning to talk for maybe thirty minutes I'll show you also two clips of of movies but I really would like to spend some time in answering your questions okay so I'm going to ask you though a several questions during during the lecture in order to make a point so you know I'm hoping that you'll give me the wrong answers okay that's what I'm hoping so don't be shy so I'm going to answer to ask you first of all if do you think that aging is mainly a result of our interaction with the environments or it's mainly the genetic make-up that we have now think about it think of what you know about aging about you your friends your parents anything like that and now I have to tell you it's an interaction really it's really an interaction of the environment of the genes but take a leadership position here and decide what's more important if you think that it's more the environment raise your hands and everybody looks around if you think the environments is the major thing good you know those of you who think it's genetics raise your hands okay I I think because of what you know about me more of you really voted for genetics but it was a kind of a split answer and let me tell you that if it was the Board of geriatrics the correct answer would be 80% environment and 20% genetics but but I have to tell you it all depends who's asking this question okay this question is asked by demographers and the MOG refers take data that they have for example the relationship between age of death of children and their parents and they look at their relationship they draw a line and they calculate what they think is the impact of the heritability and it's very complex I'll give you an example for my family my my grandfather was 68 when he got a heart disease and died my father was 68 when he got a heart disease so you see the genetics is kind of similar for cardiovascular disease but but my father had a triple bypass and he lived and died at the age of 84 and and actually what happened between them is the environment right medical progress is really part of the environment and that's what changed but it gives you it just gives you an example to show that it's a little complex to say what's genetic and what an environment and I and I have to tell you and for this audience it's the nature-nurture question that we're all dealing in in not only in medicine in other fields and in medicine where we're asking the same questions with obesity and diabetes and other things and I would just tell you philosophically for me because we are with our sets of genes in this environment it's a 50/50 collaboration okay and as long as you know that the environment is important and the genetic area is important you can work on both sides and actually if if we can find what are the genetic parts and have a strategy because of the genetics to see how we protect against the environment it'll be great because the genetic can be translated in to draw the environment we have to do things that are more difficult okay so let me give you just an example of the environment also to show you I'm going to talk about these genetic studies for longevity but I have a lab that's doing other things and I'll show you just one result of in our lab and really showing how the environment modulates lifespan we take a rats that are brothers and half of them we give whatever they want to eat and half of them we give 60% of what their brothers are eating and we're looking if they live shorter or longer and this is the result those are the guys the a L stands for ad libitum feeding they eat whatever they want and those are the animals that are calorically restricted and both they're half maximal life and maximal lifespan are increased by about forty percent and this is a study that I repeat it for some other reason in my lab but it's repeated by many other I just got the results that everybody gets and the point here they're genetically the same all we changes the calories and by the way the color is e didn't matter if you gave them the calories more from fat or more from carbohydrates or more from protein it really didn't matter much it's the number of calories that were important here let me just make one comment I don't believe that caloric restriction is important in humans in other words it is important for obese people to get thinner and I think that there's evidence that it will increase their lifespan so obese people will probably live longer by losing weight but actually then the weight that is associated with the less mortality you know the perfect weight in humans is in the border between normal weight and overweight if you know that BMI is if your doctor tells you the BMI it's about 25 okay or if you want to look at it differently it's my BMI that is the perfect and that's my excuse of not losing more more way so so I'm not I'm not telling you that caloric restriction you this as saying that caloric restriction is important for humans necessarily this study has not been done I'm just giving you an example where you can take a model and change the environment and it will have an effect and we'll get back to the environment later so you did beautifully you kind of split it the way I wanted you to split and now I'm asking another question and I'm asking you if do you think that we humans age different rates in other words think of people who are 60 years old I'm just picking an age do you know some 60 years old that look more like they're 50 do you know some 60 years old that look more like they're 70 if you do if you believe that we a we humans age of different rates please raise your hands and everybody look at it okay thank you so first of all please you're connected to Einstein don't tell them that I asked this question because because you know we are we professor asked a question in order to divide our audience like I did before not to unite them like that but the real main point is that we all intuitively understand that there are different rates of aging so why don't we try to figure out why there's such a discrepancy between the chronological age our birthdays and the biological age and maybe that how you can understand why I went 200 years old because I think this is a group that basically their aging was slower so maybe we can discover more things in this group than others okay so that's a a a kind of what we're what you can intuitively understand and what what why we're doing what we're doing let me as still as part of an introduction show you another slide and you see that let me just get okay let me just get my okay so a this this part of the slide is from the government and that's why it's not a good quality okay so I'm going to make it a little bit better and I'm putting your lines and those lines are showing the relationship between a deaths and age and the lines here are for cancer cardiovascular disease diabetes and Alzheimer's and if you notice the scale here is a logarithmic scale it goes from 1 to 10 200 so it's not an increasing 10 percent or 2 folds it's nothing like that and it just shows you that for those diseases and others aging is a is a major risk factor the risk of getting old takes you to any one of diseases from having a risk of one to have a risk of thousand now we all know that cholesterol is a risk factor for heart disease and if you go to the web of the National Health the net national issue of health lung and blunt Blood Institute you would see that that's the main risk for cardiovascular disease and it's a three-fold risk you have threefold chances of dying if you have cholesterol but with aging the risk is hundred fold and actually in the site of the National Heart Lung and Blood they they don't put aging as a risk at all so if aging is such a risk ask people in the biology of aging are looking at that and are saying you know what if we're not going to delay aging we're not going to have an impact on on the diseases of aging we can have impact on one disease and in fact that's what happened with cardiovascular you know cardiovascular diseases success we know how to prevent it you know by drugs and exercise and aspirin and those things that you know we know how to treat cardiovascular if you have a myocardial infarction you go to the hospital you'll get the stent you get a bypass we'll get drugs but you know what happened to the people who now survive a cardiovascular disease or heart attack within two years they have diabetes or cancer an Alzheimer because all we did is we fix specifically the heart we didn't delay the aging part so the aging is a much more important target for everyone then to start dealing with specific diseases of aging and that's really the message that we're trying to get out there and it's it's of course difficult because you have to do it through politicians and and even when it comes to the NIH every Institute is protecting their own turf you know so the diabetes want to do diabetes and the heart wants to do the heart and the aging is getting 3% of the funding when a when a T percent of the medical costs are in people over the age of 65 and that's where we are and and and that's why part of the importance of this research is to prove the concept that it's worthwhile to look at the aging side and you get more buck more bang for your okay so now I'll talk a little bit about my study so this is how it started we thought you know to be 100 years old is very rare when we started it was one out of 10,000 in the United States it's actually like one of 5,000 now because more people are getting to this age that are Ellis a partly Bionic you know they have replacement and pacemakers and and things like that and another medical progress but it was one at one to ten thousand so it's very rare it's very important for genetics to have something rare you know this is more rare than having cystic fibrosis okay much more rare than having cystic fibrosis which is a rare mono genetic disease so it's a rare thing and so we started collecting and we have almost 600 people that basically have to be relatively healthy at age 95 living independently and we have people with variety of age between 95 and hundred and 12 that we recruited to these studies as we recruited those people a other other groups and us unfortunately not too many other groups but the few groups that were looking at centenarians we all discover one very important thing that it's in the family that there is a heritability for that you know why do you think you live to be 100 well my mother was 102 and my grandfather was unridden 8 you get those those stories so you have a very rare occurrence and and and it's in the family so we started forming a hypothesis and I'll show you the two hypotheses that we had in order to take one a little bit off the table now okay and one hypothesis is that you know we found many causes of diseases we have genes for cardiovascular disease we have genes for diabetes we have genes for Alzheimer so maybe the hundred-years-old just don't have all those bad genes and we already know that it's not true in fact a they have in majority of cases they have just as may as bad as many bad genotypes changes in their genes in the bad genes as the rest of the population so it's not that their genetic makeup is better in this sense they don't have the perfect genome in this sense so this leads to number two and number two is that it's not that they have perfect genome but in their genome they have something that protects them against everything else that they have they have a longevity gene or they have a protective gene and those are the things that we're discovering and working on and those are the G the discoveries that are leading now to a development of drugs so I'd like now to introduce you to a one-family those are for children that were born to two parents in New York between 1910 and 1920 the first kid died this the sister that's standing there on the right died at the age hundred and two to the shock of everybody there the old sister a died at 810 exactly a year ago and the two brothers are alive one is 107 or 108 now and one is a hundred and six and the point here is those are the only four kids that were born to two parents in New York City okay they were born like where you were born and where your parents were born they all made it past hundred in too far in two hundred and hundred and two till showing you the genetic aspects but what I want to do is I want to show you is a clip of of the brother that's sitting there with a gun who's his name is Aaron Cohn and he allowed us to use this clip it was done two years ago he's still going to work everyday and you'll see in the film that he is his sister who was alive then I just came dropped in for a visit so you'll have a glance of both of them in this office building on Madison Avenue New York City 104 year old investment advisor Irving Kahn is working hard as he has since his career on Wall Street began in 1928 he shares his secret to a long and healthy life to wake up in the morning and have something to look forward to Irving's curiosity and keen business sense have led him to become a widely respected value investor a member of the New York Stock Exchange and chairman of Cohn brothers the company he founded more than thirty years ago with two of his sons including Thomas who is the president curving works five days a week with a 67 year old son and 29 year old grandson Andrew playing an integral part in managing over 700 million dollars in assets Irving's first business venture was as a boy selling newspaper subscriptions for a nickel so that he could buy a bicycle he recalls how his father taught him to ride we lived on 106 Street there's a white straight here my bad and he should sit on the street and hold on my handlebars gave me a push you know I was out in the middle of the street still not 40 what could I do it I learned how to write very quickly he taught me how to swim as well he pushed me to water Irving says those were the first steps in learning how to do things for himself shall be the paper Thomas believes his father's thirst for knowledge fuels his drive work is his life so he's always been a absorber of information ever since I was a child he would bring home on your reports and read them at the dinner table it was and that's what he still does and Irving says not working is unthinkable I would pay you if you took it away from me I try to buy it back he believes mental challenge is key the important thing is to keep it very nourishing to stay sharp Irving reads materials online to financial newspapers daily and a wide range of nonfiction I read a lot of science I read no fiction no mystery stories and no such novels so that leaves a lot of time science and it was servings interest in science that led him to participate in the longevity genes project at Albert Einstein College of Medicine led by researcher NIR Barzilai NIR and his team have recruited more than 500 healthy elderly ages 95 to 112 and their children Irving and Thomas are part of the study as is Irving's big sister 108 year-old helen Reichert a former television host and fashion historian she recently had a stroke but is otherwise in excellent health so far NIR and his team have found several gene variants that are more common in this group and protect against cardiovascular disease type 2 diabetes and Alzheimer's erin has the ctp genotype that seems to be protective against several age-related diseases including cognitive decline nears team has also found that some genes seem to protect against the effects of certain lifestyle habits Irving for instance used to smoke but quit to set an example for his children and Helen smoked for more than 80 years you can see both from him and his sister that those genes have amazing effect not only on the fact that they're alive but considering the fact that they were smoking and this should have shortened their lifespan immensely and Irving believes long life has its benefits when it comes to business because part of it is some of the advantages that you have when you're older you know what's rotten and what's fresh and what it's good or bad you can participate a higher level of successful choices as Irving invests in maximizing the value of each day Thomas appreciates his rare opportunity I enjoy debating with him about business subjects and you know in our business you can say this is white and I can say it's black and we can argue about it but there's no debating that Thomas wants to follow in the footsteps of the man who showed him the ropes in business and who soldiers on every day at 104 and Counting so I want to make sure that you understand I will show you this clip basically to show you that if you're healthy at 107 you can have really good life okay because a you know the public when I say the public hundred years old who wants to be hundred years old well if you're healthy and have good life you want to be hundred years old okay that's that's really the point that I want to make he had not not anymore he's that he's the rare ones whose wife died before we don't know we don't know right maybe a secret life so I want to make another point because it was partly made here but you would say you know there is another thing maybe those guys were just perfect with the environment okay maybe they were lean non-smoking you know drinking the right amount of alcohol exercising maybe vegetarian all that thing that is important so let me show you a overweight and obese almost half of them were overweight or obese okay so it's a group they weren't special smoking sixty percent of the men and thirty percent of the women alcohol daily you know you want to have one glass of wine it's it's rare a physical activity now I'm talking about walking cycling housework less than half of them vegetarians 2.6 percent of them okay so the point here is a group we're not finding that they were unique even the people who said oh no food you know was very important for us when you ask them how come they said because we had chicken fat every day or you know or we had chocolate or you know the yeah but that's that's what they are and and by the way we controlled it for people who lived at that time that we had information and they were either as good or as bad the as s bed or a little worse than people in their cohort when this study came out that was my nightmare that people will say okay there is a proof that we don't want to do what the doctors tell us to do now for us for most of us that don't have longevity in the family we have to do what the doctors have to do the point is with those some of those hundred years old it really didn't matter whether they did it or not because they were going to make it anyhow okay so that's the point and please I don't want anybody to say we just heard that we don't have to exercise or something like that that's that's let's say not my message okay so let me tell you so I talked with you about a bunch of hundred years old but I'm a scientist you don't do science on a group without having a control okay and it's a problem because the people who were born in their cohort died 50 years before so we don't have on average so we don't have the right control and what we've done in this study that is unique is we recruited not only the hundred years old but their offspring their children but by the way I used to have children too right children but now offspring because when we go to our protocol for approval and the cover letter said we're going to look at centenarians in their offspring it came back on my desk the next day saying four children I mean centers and the children they say four children you need other forms okay but their children are 70 years old can take care of themselves you know so it's their offspring and and there's a lot of reason why we take the offspring that I'm not going to to get into now but the offspring are we think are enriched with those longevity genes let's say they have 50% of at least of what it takes some of them have more some of them have less of what it takes and the advantages that for the offspring we can have a con trol we can have people that we can match with gender you know and an age to the offspring and that's how we can design a study that is genetically valid okay and in fact we have a study going on looking at the offspring of centenarians moving on to see how our genes influence their aging but rather than what we did was which is called cross-sectional in science you know we just took the people in their offspring and just looked at the difference we're going to look forward now and validate our our studies the last point that is very important about our study that it's in a done in the Ashkenazi Jews and the reason we do it is not that the Ashkenazi Jews are known for living longer or living shorter we assume that they live as much as any other group but it's a technical issue because for genetic reasons you want to deal with a homogenous population because otherwise the genetic noise when we do the testing is very very large particularly in New York you can just walk in the street and understand the genetic noise just looking at skin color is a good indication of genetic noise so the best population in the world by the way for genetic studies today is the icelandic s-- okay iceland is an island with 500,000 people who are all children of five vikings and four irish women okay there are brothers cousin and so if you take this population and some of them have diabetes and some do not you can actually find good genes for diabetes on the background and and this is the idea behind a using the Ashkenazi Jews and we believe that it's a it's a it's a cost-saving in other words that that we need much less people in order to get better results that if we would have gone all over and take everybody to our study and I can talk about it more later and just to show you where we are I'll give you this example this is an example of several age-related diseases hypertension diabetes myocardial infarction and Stroke and the red people are the control to the the black the blue group that is the offspring of centenarians and you see that the offspring of centenarians they're the same age and they have less hypertension less diabetes less myocardial infarction and Stroke so for the same age they're healthier but I really want to bring in the hundred years old the centenarians in green because although they are thirty years older than the red group they barely have the same prevalence of hypertension much less diabetes and just about the same prevalence of myocardial infarction and Stroke so you see that from an age-related disease perspective their aging was delayed by a by 30 years okay and and that gives you a glimpse of of the study the offspring are healthier and the centenarians looks like the aging disease even heat them as much okay let me make another point on Aging that's behind some of some of the thoughts we have in the field and and what you have here is just a graphic presentation that I've done that showed how youthfulness declines with age youthfulness now when I'm saying youthfulness decline you can measure things and they can go up or they can go down but they're changing with age and the things that you hear a lot about is sex hormone both dasta's droning men estrogen in women is going down growth hormone is going down but what maybe you don't see clearly there are hundred things that each one of us in the biology aging has his own idea of what's causing aging and and so there are lots of things that we're looking at now when you take each one of those lines a there are two things that that they can prep resent one is maybe they caused the aging and they're very important because of that because we want to know what's cause aging the second thing is maybe you can monitor maybe it happens with aging maybe it's even a good marker of how old you are but it's not going to kill you or not going to kill you in our lifespan that is you know about 100 to 120 years okay so those are obvious thing but what haunts the field now is the fact that some of the things we're monitoring with aging are not causing and not happen with aging but they are the protection against aging because you know when we have an infectious infectious disease there's an inflammatory response right we know what to do that when there is the breakdown in aging there is a lot of possibility to repair and protect and modulate and stress response and others and so we don't know what is what and that's very confusing because if something goes up and it's part of the repair we don't want to bring it down if something goes down because it's protective when it goes down we don't want to get it up and the point is best made really with the what happened with the women health initiative where they decided to give women estrogen because their idea was that estrogen is going to delay the whole aging process and indeed when they gave estrogen some things were better okay for example the skin was much better but overall the study was stopped because of cardiovascular disease cognitive decline and breast cancer so in fact at the end estrogen ended up to be pro aging and not against aging and again the point here is not everything that changes if you want to look from longevity perspective needs to be repaired a another way to say it estrogen is a youthful hormone on a young body the question is is it youthful hormone on an old body and the environment of all body is very different and it all has to be tested by the way estrogen probably should I could be used between age 50 and 60 in most women that's a time where a probably there's more benefits than risk but as you understand I have a problem with that because I said some people are aging sooner and some later so the real window is cannot really be determined so we don't know but there there's probably a safe window where estrogens can be used but really the the point was just to show you an example where everybody thought hey estrogen will make everybody young and it didn't not from an age-related disease perspective by the way since the WHI that is exactly ten years ago since they came up with their study and people haven't given estrogen as much the incidence of breast cancer have decreased by 25% in the United States so it has a real real effect okay now a as a just few points about the genetics and I'm really not going to give you a lecture in genetics and I'm I have five slides to finish so I know I'm running a little later than I thought so what you see here is you see the sale you know it represent of the cell in the body and the cell has a nucleus and in the nucleus there the chromosome so let's remove one of the chromosome and it looks like that and let's start pulling this chromosome from its end and stretching it out and eventually what you get is this double helix DNA that is that has the genetic code and really what we are looking for is we call it either mutations mutation you probably understand the concept but we call it sometimes variance or snips and we're looking for those that are going to change the composition of the protein that is being produced by this code and have some foreman effects so we're going to look at that we're looking at that but I just want to make a point that the environment interacts our gene in a mechanism that's called epigenetics it's not clear genetic the genetics that we are born with is not changing but the epigenetic mechanism something that right on the gene and tells the protein to to be produced or not is changing and this is a lot of our effort is to find the epigenetic mechanisms of aging but that's the only sentence I want to say for their curiosity okay now what we found is we found several genes that are associated with longevity and I'm just going to say a word about each one of them but what's important to know is that the pattern a each one of the line represent a certain genotype and it doesn't doesn't matter if you understand it or not but but what we want to see is what happens to the genotype with age and if it increases with age you know from 65 and it's very representative at age hundred we say that that's a longevity genotype because there are more people with hundred that are 100 years old with these genotypes so that means a could have played a role in their longevity now the one that is more rare it happens only in 2% of centenarian is an interesting story because it represents something that happens in nature in nature within each species the dwarf models live longer in other words the Pony live longer than the horse the small dogs live longer than the large dogs when you do experiments in the lab and mutate the growth hormone jeans or receptors they all live longer in a subset of our centenarians they're not really dwarf they're a little smaller but a but they have a functional mutation in their growth hormone receptor and we see it only in centenarians so it's probably true also in humans those two are lipoprotein genes and you see they go from 8 to 10% at age 65 to about 20% at age 100 and the thing that they're doing most commonly is they're increasing the good cholesterol the HDL cholesterol so if your HDL cholesterol is high and your family history of longevity you're on your way to longevity I would say at least in potential another one is the thyroid the centenarians and their children are not hypothyroid they don't have a low activity of the thyroid but they're set up is relatively lower to the rest of the population and there is a whole I pathi sees of aging that has to do with a basal metabolic rate which is what the thyroids are are doing that if your metabolism is fast you're just going to die sooner and if it's slower it'll take you longer there's even work suggest that the heart beats are really the best indication of longevity so mice have 250 heartbeat for per minute and men have much less so this is some of the idea okay I'm running out of battery so that's a good a good reason to stop soon so let me just tell you that this this one the CTP and I won't take you through this slide because because of the battery neither but basically we showed in our study in another study on non-jewish people that if you have this variant in your genetic makeup you're protected from Alzheimer by about 70 percent so it's a really strong protection from Alzheimer's okay and the important thing is that Merck and Roche are actually developing a drug - they are developing to increase HDL and prevent cardiovascular disease but it will be tested also because of our studies will be tested also on cognitive function so the point here is to go from genetic discovery to drug development and to testing it against aging is something that's happening and we need it to happen more often I just want to make a point about the cost okay of living a longer but the the point is about the cost of living healthier and the first point I want to make is that while people who died 80 are sick at the last five years of their life they had a heart attack they have diabetes they had cancer a people were a hundred years old in our study we're on every sick in the last eight months of their life so not only they lived healthier for many years but the time that they were sick was lower and this has been translated to a cost saving in the sense that if you die the last two years when you're 100 compared to the last two the cost in the last two years when they're you're seventy is about third okay about third of the cost and not only that the hundred years old when there 6070 they even didn't go to the doctor so there is a lot of issues if you live longer there is social security there's retirement there's lots of issue and I am NOT I'm not going to be an expert to comment on them but at least for medical costs there's a cost saving to be healthy so just a just a a word about Moses and for me the most amazing thing is that people are a religious people believe in every word that says in that's written in the Bible okay when I come to this they say ah they didn't know to count you know all of a sudden this is nonsense okay it's kind of an amazing a certainly a longevity genes drowned with a flood you see here with nor there's an interaction with the environment right also please note that Joseph lived relatively short to the guys at that time which shows you that even then to be a secretary with the Pharaoh wasn't really great right why did Moses leave 220 did he leave 220 is a different issue but I would say that one part of it is by the way considering the fact that the last 40 years were a bunch of complainers in the desert right but I I think that part of it is that they were partially maybe adequately caloric restriction restricted and exercising so it could have contributed to you know apparently Moses longevity was unique compared to the other people in the tribe and so you know maybe there is some interaction with the environment that helped him now I want to just tell you about Frieda who's coming with me to lectures all over the world her son Jerry is here a and he's married to Bernice they are my in-laws so Freda was my grandmother-in-law and a lot of what I learned that centenarians and how they are presented I've learned through her and this is how she drinks was very cold from the bottle at a at her 100 year old birthday and she was really quite an incredible a person and she was a healthy basically until two weeks before she died it was hard to always tell any doctor who saw her that she's not taking medications right it was like what are you taking what are you taking nothing no no you don't understand in the morning you know with breakfast no I understand I'm still I'm still taking nothing so she's an inspiration and also I would summarize by saying that I think if we prevent aging we can prevent age-related diseases that the research to the biology of genetics of aging is bearing fruits and medications I gave an example and also the point that healthy aging is not going to destroy us necessarily there is a balance there are things to do I want to just mention that Carol stem is our research coordinator ship can you wave and if you know of centenarians if you're interested in the study if your offspring of centenarians we're going to hang around here and we'll be happy to take your names and know more about it and just to remind you that our goal is to prevent the chronic debilitating age-related disease we're really about quality of life and when we have the drugs they might have a side effect of living long and we'll apologize for that so thank you for listening it was a pleasure to talk to you and I'll stay around for some questions

Channel: Albert Einstein College of Medicine

Views: 10,453

Keywords: aging research, aging, anti aging research, genetic research, nir barzilai, longevity genes, prevention of aging, delay aging, aging and genes, the longevity genes project, instutite for aging research, super agers, superagers, centenarians, Ageing (Literature Subject), cost of aging, 92YTribeca, montefioreeinstein, montefiore medical center

Id: r42-amLc8kw

Length: 49min 38sec (2978 seconds)

Published: Fri Dec 21 2012